Protein Alignment CG42795 and Tbc1d10b

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_001102391.1
• Gene: Tbc1d10b / 365372
• RGDID: 1309191
• Length: 795
• Species: Rattus norvegicus
• Alignment Length: 876
• Identity: 173/876 - (19%)
• Similarity: 272/876 - (31%)
• Gaps: 339/876 - (38%)

  Fly   108 TAVLIVE-SDDAQPKMRFSLSPPPQKAITSARL---TSPTKNSLSSNNTITTPGSNNRSPSSTKT 168
            |..|.:| |.:|.....|........|.||..|   |...|...:..:.:..||:..|:||.|.:
  Rat    81 TVELTLEASPEAAKTQEFPAPAAEAGAETSVALVLGTDTPKTEEARASPVPGPGTPTRTPSRTAS 145

  Fly   169 TMLT-------------------RNG-----GGHGTSPTAS------------------------ 185
            ..||                   |.|     ||||.:.:||
  Rat   146 GALTAKPPLAPKPGTTVASGVTARGGAGQVAGGHGAATSASAGPVPEDPSGPVTGPPGTCEASAP 210

  Fly   186 -------------------GS------------GHAPSATAAADD-------------------- 199
                               ||            |.||...:..|.
  Rat   211 VARVTVTPAPETTENFQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLTDDVSSVGS 275

  Fly   200 --------------------------------------------EATSDYNQWL--HAMKLVARL 218
                                                        |..|::::||  ...|:..|.
  Rat   276 DSEINGLALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLEMFSNWDKWLSRRFQKVKLRC 340

  Fly   219 PGGTPPEFRRKLWLSLADKYLKSKNVDWAQQREKCFCEEWREDDEELGIQIV-KDLHRT-GSNLC 281
            ..|.|...|.|.|     :|| |.:.:..:|....|.|..|...:...:.:: |||||. ..:..
  Rat   341 RKGIPSSLRAKAW-----QYL-SNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEM 399

  Fly   282 TGPAGSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMKVMIYLVEGVLPTG 346
            ....|...|..|.|||..|..|.|:.||||....:.|::|  |....|::...::.:.:..|| |
  Rat   400 FAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLL--MHMPAEQAFWCLVQICDKYLP-G 461

  Fly   347 YFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFCTCLPM 411
            |:...:..:|.|..:|..|::...|...:||:|      ...:|.|   :..:||:.:|...||.
  Rat   462 YYSAGLEAIQLDGEIFFALLRRASPLAHRHLRR------QRIDPVL---YMTEWFMCIFARTLPW 517

  Fly   412 SCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVISVRSADEFYGKMGSYSSELLNGHLVDSNGLI 476
            :.||||||:...||..::.|.||||.......|..:||....|..|....:  |....:..:.|:
  Rat   518 ASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRN--LPQQCMQEDFLV 580

  Fly   477 ERVVKLGPIEDLRQLRDKHLYNIAPLRHKQGLQLYYDEEDTHSDEERLAVATVFGLNWGRRGSVG 541
            ..|..|...|.|  :..::...:...|..:|...|......|
  Rat   581 HEVTTLPVTEAL--IERENAAQLKKWRETRGELQYRPSRRLH----------------------- 620

  Fly   542 PAAAGKQQVEQKDRLALDISLLKKQYDRLRERQKQAHVILTTACSTAARQGSGPASSSQPAVPVN 606
                |.:.:.:                   ||::|...:             ||:||
  Rat   621 ----GSRAIHE-------------------ERRRQQPPL-------------GPSSS-------- 641

  Fly   607 QLLLGRPAIVTNKGKRVGAPLGAIPPARK-----------------PSLPAVLHTKPT------- 647
              ||..|::.:...:.||......||.|:                 ||||:     ||
  Rat   642 --LLSLPSLKSRGSRAVGGAPSPPPPVRRASAGPVPGAVVIAEGLHPSLPS-----PTGNSTPLG 699

  Fly   648 SEKQLRRGETLLWRDTDPSRRRRDSLTWKEIKADRAAMIREGVDVSSVRTQKLRTRFGKSDSSSY 712
            :.|::||.|        ..|::::    ||.:.:|....:|     ..:.:|.|.::.|
  Rat   700 TSKEIRRQE--------KERQKQE----KEREKERQRQEKE-----REKQEKERQKWEK------ 741

  Fly   713 SEDSDGEQESGTGGGGGSSTDTSLCDDDDPKSTEKSPKQKAKLARKLKEQKQLAGSRETSLERQR 777
                  |||                     |..:|..|::.||.:|       ...|:.||.|:.
  Rat   742 ------EQE---------------------KEQQKQEKERQKLEKK-------GQGRKLSLRRKA 772

  Fly   778 PKSWAPSSHEIPFMLMGTDSGDEKEDKSTKE 808
            ....||.           |.||....::.::
  Rat   773 DGPPAPQ-----------DGGDRSAAEARQD 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	54/176 (31%)
		DUF4682	560..689	CDD:464830	29/152 (19%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
Tbc1d10b	NP_001102391.1	PHA03247	<5..223	CDD:223021	28/141 (20%)
		TBC	340..545	CDD:214540	66/222 (30%)