Protein Alignment CG42795 and Evi5

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_727526.2
• Gene: Evi5 / 32088
• FlyBaseID: FBgn0262740
• Length: 807
• Species: Drosophila melanogaster
• Alignment Length: 1064
• Identity: 209/1064 - (19%)
• Similarity: 359/1064 - (33%)
• Gaps: 348/1064 - (32%)

  Fly   101 EVLCEFVTAVLIVESDDAQPKMRFSLSPPPQKAITSARLTSPTKNSLSSNNTITTPGSNNRSPSS 165
            ::|.:...|..::|||              .|::.|...|...|||.:|..::|:.| |:.:...
  Fly    37 DLLAKLEAANKLIESD--------------AKSLNSLHSTHSRKNSDTSQISLTSSG-NSVAEED 86

  Fly   166 TKTTMLTRNGGGHGTSPTASGSGHAPSATAAADDEATSDYNQWLHAMK--------LVARLPGGT 222
            ..||..|                               ..|.|..|:|        ||.|   |.
  Fly    87 IWTTWAT-------------------------------ILNDWEGALKRKNPCVSELVRR---GI 117

  Fly   223 PPEFRRKLWLSLA-----DK-----YLKSKNVDWAQQREKCFCEEWREDDEELGIQIVKDLHRTG 277
            |..||..:|..|:     ||     |:|:.:.          ||:          .|.:|:.||.
  Fly   118 PHHFRAIVWQQLSGASDGDKKQYAEYIKATSA----------CEK----------VIRRDIARTY 162

  Fly   278 SNL-----CTGPAGSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMKVMIY 337
            ..:     ..||    .|..|..::..|:.::.|||||||...:..|:|  |...|||:..|::.
  Fly   163 PEVEFFKEKDGP----GQEALFNVIKAYSLHDREVGYCQGSGFIVGLLL--MQMPEEEAFAVLVQ 221

  Fly   338 LVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFL 402
            :::.......|..||..|...|.....|:|.::|.:..|.|: ||     |:   |.::...|||
  Fly   222 IMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQ-QG-----FQ---TTMYASSWFL 277

  Fly   403 TMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVISVRSADEFYGKMGSYSSELLNG 467
            |::.|.|.::...|:.|:.|.||.:.:.:.||.|....::.::.:    :....:..:..||...
  Fly   278 TLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCL----DMEAMLKFFQKELPGR 338

  Fly   468 HLVDSNGLI----------ERVVKLGPIEDLRQLRDKHLYNIAPLR--HKQGLQLYYDEEDTHSD 520
            ...|..|..          :|:.|:.  ::.:.|:.|....:|.||  .::...|....|...::
  Fly   339 VEADVEGFFNLAYSIKLNTKRMKKME--KEYQDLKKKEQEEMAELRRLRRENCLLKQRNELLEAE 401

  Fly   521 EERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLLKKQYDRLRERQKQAHVILTTAC 585
            ...||...|       ||.|..|    ::.|....:..::..|::.|..:..:.:.|
  Fly   402 SAELADRLV-------RGQVSRA----EEEETSYAIQTELMQLRRSYLEVSHQLENA-------- 447

  Fly   586 STAARQGSGPASSSQPAVPVNQLLLGRPAIVTNKGKRVGAPLGAIPPARKPSLPAVLHTKPTSEK 650
                                |:.:.|                                      .
  Fly   448 --------------------NEEVRG--------------------------------------L 454

  Fly   651 QLRRGETLLWRDTDPSRRRR-DSLTWKE--IK---------ADRAAMIREGVDVSSVRTQKLRTR 703
            .||..|..:..|::.||:.. |.|..||  :|         .:....:|:|:..|..:.:.|
  Fly   455 SLRLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNL--- 516

  Fly   704 FGKSDSSSYSEDSDGEQESGTGGGGGSSTDTSLCDDDDPKSTEKSPKQKAKLARKLKEQKQLAGS 768
              |:......||....:|        ::.|.|:....|.....|..:.:|.|:  ||:.||....
  Fly   517 --KAKVEELEEDKKTLRE--------TTPDNSVAHLQDELIASKLREAEASLS--LKDLKQRVQE 569

  Fly   769 RETSLERQRPKSWAPSSHEIPFMLMGTDSGDEKEDKSTKEGPITGDQAEDSATESGHYEFDRELH 833
            ..:..:||                                      .||:..:||     :|..:
  Fly   570 LSSQWQRQ--------------------------------------LAENQRSES-----ERTTN 591

  Fly   834 LVSSKMEPLKLPFDPEFTGMTSVSPIPTPREKSEAEEDLLDERKPFDVSDDGVTNQYFERVNSVE 898
            .|.|..:.|...|   |....|      .....:.||:|:.                 .|:..:|
  Fly   592 AVDSTPKKLLTNF---FDSSKS------SEHTQKLEEELMT-----------------TRIREME 630

  Fly   899 RPNRL-ELTYSLNEEETDTNAIYLEEREKVEGHSGDREYNSLPPFYPRENDDGVQGGGKVPQIRD 962
            ....| ||...:.|.||.......:.|.:.|.|...:|  .|.....||.|  :....:..|.|.
  Fly   631 TLTELKELRLKVMELETQVQVSTNQLRRQDEEHKKLKE--ELEMAVTREKD--MSNKAREQQHRY 691

  Fly   963 DNIPGENKDDYKELLSMTIEENTVYKPPTPTASTLSNASRKRRDPRRKTLTRSSTI-EIEERYQA 1026
            .::....||   ||:::.|                            |...:|.|: |:::....
  Fly   692 SDLESRMKD---ELMNVKI----------------------------KFTEQSQTVAELKQEISR 725

  Fly  1027 LERRISQDQPSGDRQAKYIPSTAA--LEERFNTLEKQLSAEKQRKELSEMEAEYP---IKSERIP 1086
            ||.:.|:....|:.:|....|...  |::|...::.:|:|.|.|       .::|   ::|..|.
  Fly   726 LETKNSEMLAEGELRANLDDSDKVRDLQDRLADMKAELTALKSR-------GKFPGAKLRSSSIQ 783

  Fly  1087 STADLESRFNSLTK-QMSSSESSS 1109
            |....|..||.|.. :..|:|.|:
  Fly   784 SIESTEIDFNDLNMVRRGSTELST 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	51/179 (28%)
		DUF4682	560..689	CDD:464830	17/140 (12%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
Evi5	NP_727526.2	TBC	113..320	CDD:214540	65/244 (27%)
		Smc	<358..>761	CDD:440809	102/600 (17%)