Protein Alignment CG42795 and tbc

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Alignment Length: 1234
• Identity: 222/1234 - (17%)
• Similarity: 376/1234 - (30%)
• Gaps: 371/1234 - (30%)

  Fly  1063 SAEKQRKELSEMEAEYPIKSERIPSTADLESRFNSLTKQMSSSESSSKTPIDLKDEDRPSGSSSK 1127
            |.:|:.|:|.|                      .::||:....||||.|.:....|...|....:
  Fly    18 SVKKEVKQLME----------------------EAVTKKYVHEESSSVTSLCGAVEACLSQGLRR 60

  Fly  1128 NQ----KDSEKTSKLHKSEEPESNTKETTGETEASDSNDSKIGEKETEQPRIKKLPSTAELEDRF 1188
            ..    |.|..|:.||                        ||.:...|...|.||....|..|
  Fly    61 RALGLFKTSSTTALLH------------------------KIAKSCPEAEHISKLVQEIEASD-- 99

  Fly  1189 NALERKMSVQKSSPSKNKKEPPDEEESKSTKEPEEPEESEKANEKTSGRQTPIAKKDSKDSDQ-- 1251
                  .|.:.||.|.:.:.||..::|.|    ........|...||.....|:...|..|..
  Fly   100 ------PSKRSSSSSDSFQRPPMLKKSSS----NSMSTGTNAAASTSSASASISVSASTSSMSLA 154

  Fly  1252 ------------KKSETK------ENQSPTKNQDEKVK-----------VKSPKSEEMIEKETSS 1287
                        :|..||      .|.|...::|..|.           :..|.:.|....:|:.
  Fly   155 SMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGSILSSLLVGPCALEFTRAKTAD 219

  Fly  1288 NPKEDSHESEAATNKKVEGNRELSSEKGDHKIKEKSEEAPGKAGKETAETKNANVKDSSKKGDSQ 1352
            :...|.|..|.....::...|..||......|               ...|.:....|.:.|...
  Fly   220 HYWTDPHADELVQRHRISSCRRSSSTCSRPAI---------------INFKRSLNTSSDEAGTGS 269

  Fly  1353 KNEAAKTSVSQTESDLKPSSKENSTSKDAEQEKTPRKSPPSTEELEKRFNALEKQMSTTNLETTK 1417
            ....|..||::   |...|..:|:.:.....:...:..|....|....:.:|.:.:.|..::.|
  Fly   270 FKSIASASVAK---DYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTIKWT- 330

  Fly  1418 EPDQTKPATKSQSTSAEVKTQKSMKSFDDKIKEVN----VAIEKEQSRVE------VEVNAEKKR 1472
             |:|    ..:..|.||........:|......:|    |.:...|||.|      :.|..:..:
  Fly   331 -PNQ----LMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQ 390

  Fly  1473 KNVEEAPKNKEGDSQQPEESQHKGKNQRRASEPP--STEDLEKRY---ETLKRRMSSKNQFSETV 1532
            :.....|:.  |..||.......|.......:||  |...:.|.:   .:::||:..  ...|:|
  Fly   391 RPPIHFPEG--GHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILP--SVMESV 451

  Fly  1533 DEALERIQQEVISEAVEEK-----------KPPPSTEDLESRFEALHGDKKNVESKMDETKHVDV 1586
            ||........::|::..|:           :..|....|.|.......|..|....:|:.
  Fly   452 DETPIDYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCSTTGSSDCSNKSLSIDQF----- 511

  Fly  1587 AIEAHIPSPPPPPPPPKERPVLAEPVLHQQQAL-------IEELQSKMRGQSPGE---------- 1634
                           |.|.|::.:....|||.|       ||.:.|.||.|....
  Fly   512 ---------------PMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCR 561

  Fly  1635 ---------ENLKPSEINPQRRQKKLLQRPTPMGDETSEAPANTAYYRAANHEQWQQRMVRRFSD 1690
                     ..|....|.|:.:           .||           .....|:||.
  Fly   562 HLSTVRTHLSGLVHGRITPEMK-----------ADE-----------EGLTKERWQL-------- 596

  Fly  1691 LPSRADLENRLQF------------LERQLY-----------------------KKFYK----QR 1716
            |.....|||..:|            |.::::                       |.:|:    :.
  Fly   597 LNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEW 661

  Fly  1717 CASDSEVASR---------VKLPPEDQPSTSRQARKQ--EAEGQLEQRVLALEKQLSE-NSLKLL 1769
            .|.|:.|..|         .||.........|..|..  ||.|.||..|......:|: ..|:..
  Fly   662 LAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFD 726

  Fly  1770 EAMRERHRSADDSGSPRRLSTETID---ATGKELVRYTQNIGELEEVDAHKPINISINIKMMVNK 1831
            |..:::.:.|:.:.|...|:.:.|.   .|..:.....::..||:|.|               .:
  Fly   727 EQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPD---------------EE 776

  Fly  1832 DSESKQPKGESKPTTEDLTRRLEQLEQQLLEERAKNGSIPPENEVLEEKPEKLEEKDSCKKQEKN 1896
            |::.||.:.|....:|.......:||:|:.:|.:.:.|.....|.:  .|.::.       |..|
  Fly   777 DNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETV--GPGEVH-------QRPN 832

  Fly  1897 CHNQHVKGDE---VEKTEIPAD----RKIEPASAKETKTLENVEKAQTRAKVVDTEKSVKDQNAV 1954
            ...:.|...|   .:..::|.|    |...|.:|               |.|:.|:.||...|..
  Fly   833 SDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAA---------------AAVIITKASVDITNWE 882

  Fly  1955 TDEKSVQ-DQNVVVDKKADRKILDKKDKSPAAGKSEDTKQTSGKKEKSEDIKQASEAPKAGASKE 2018
            ...|:.: ||...::::|        .:|..||.:.|                |.:.||:..:..
  Fly   883 RSPKAAEGDQMSPLEEQA--------GESGGAGVNMD----------------ALQQPKSACASP 923

  Fly  2019 TSTRGKPSETKLEKPTTKESVLKETFPKKENLESEKPKSKENEATKTETQKSKETPTVAVSPKE- 2082
            .|:.|....::|         |::.......:|.:..:...|..........|....::....|
  Fly   924 ASSNGGVYSSEL---------LEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEH 979

  Fly  2083 ----------SKVSSKQMTEKKETIKDSSSKELPEKMVINSTDVGPMD---PNGKTVVLLMDNE 2133
                      ..|:...:....|::..|...:|.|:|:.|....|.||   .|.::::.::|:|
  Fly   980 LDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSE 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855
		DUF4682	560..689	CDD:464830
		PTZ00121	<1112..2009	CDD:173412	187/1045 (18%)
		PTZ00121	<1740..2340	CDD:173412	78/422 (18%)
		PTZ00449	<2270..2610	CDD:185628
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049	49/250 (20%)
		PH_RUTBC	292..466	CDD:275431	34/183 (19%)
		TBC	923..1087	CDD:214540	21/130 (16%)