Protein Alignment CG42795 and Tbc1d9

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_001402001.1
• Gene: Tbc1d9 / 304645
• RGDID: 1308221
• Length: 1262
• Species: Rattus norvegicus
• Alignment Length: 1194
• Identity: 255/1194 - (21%)
• Similarity: 404/1194 - (33%)
• Gaps: 392/1194 - (32%)

  Fly     1 MSETKKLLDAL-------LCDIYG--RQEVLAKRIRRCCRDPVHKRSPKKKKGQLAQLASGMVGD 56
            ::||.||::.|       |.|..|  :...|.|         :.|:||||.......|.:....:
  Rat   238 INETFKLMEQLANIAMRQLLDNEGFEQDRSLPK---------LKKKSPKKVSALKRDLDARAKSE 293

  Fly    57 R-SSLERLDVRKLID---VCAILKVEILMLGYLLERVLVARDRL--QRHQEVLCEFV---TAVLI 112
            | .:|.||...:.:|   .|.:......|  ::|.::.|:.:.:  ...:|.||..:   ..|.|
  Rat   294 RYRALFRLPKDEKLDGHTDCTLWTPFNKM--HILGQMFVSTNYICFTSKEENLCSLIIPLREVTI 356

  Fly   113 VESDDAQPKMRFSLSPPPQKAITSARLTSPTKN---------SLSSNNTITT-------PGSNNR 161
            ||..|:     .|:.|.|....|..|:|....|         .:|.....||       .||.|.
  Rat   357 VEKADS-----CSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSRIYSEFSGSCNS 416

  Fly   162 SPSS--TKTTMLTRNGGGHGTSPTASG------SGHA-PSATAA--------ADDEAT------- 202
            |...  ::.:.|..:.....||..|.|      :|:: |:||..        :.:|..
  Rat   417 SDDEVYSRPSSLVSSSPQRSTSSDADGERPFNLNGNSVPTATQTLMTMYRRRSPEEFNPKLAKEF 481

  Fly   203 ----------SDYNQWL------HAMKLVARLPGGTPPEFRRKLWLSLADKYLKSKNVDWAQQRE 251
                      ::|.|.:      ...:||.:   |.|...|.:|||.|:...           .|
  Rat   482 LKEQAWKIHFAEYGQGICMYRTEKTRELVLK---GIPERMRGELWLLLSGAI-----------NE 532

  Fly   252 KCFCEEWRED--DEELG------IQIVKDLHRTGSNLCTGPA--GSINQAKLKRILLGYARYNPE 306
            |.....:.||  ::.:|      .:|.:||||   :|...||  ..:..|.|:|:|..||..||.
  Rat   533 KATHPGYYEDLVEKSMGKYNLATEEIERDLHR---SLPEHPAFQNEMGIAALRRVLTAYAFRNPN 594

  Fly   307 VGYCQGFNMLGALILQVMDKEEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLP 371
            :||||..|::.:::|  :..:|||:..:::.|.|.:|| .|:...:.|...|.|||.||.:..:|
  Rat   595 IGYCQAMNIVTSVLL--LYAKEEEAFWLLVALCERMLP-DYYNTRVVGALVDQGVFEELARDYVP 656

  Fly   372 RLAKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVL 436
            :|...:|.|          .:.:..::.||||:|.:.:|....:.|.|....||..|:.:.||.:
  Rat   657 QLYDCMQDL----------GVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAV 711

  Fly   437 WSLLEERVISVRSADEFYGKMGSYSSELLN--------GHL-------------VDSNGLIERVV 480
            .....::::..:...|....:|.|...:.|        .||             ||    |.|::
  Rat   712 LDANVDKLLGCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVGPYPAVD----IFRLI 772

  Fly   481 -----KLGPIE-DLRQLRDKHLYNIAPLRHKQGLQLYYDEEDTHSDEERLAVATVFGLNWGRRGS 539
                 |.|.|. ||          |..:|.||.|::....|||   .:|..|.|:
  Rat   773 GTSYEKFGTIRADL----------IEQMRFKQRLKVIQTLEDT---TKRNVVRTI---------- 814

  Fly   540 VGPAAAGKQQVEQKDRLALDISLLKKQYDRLRERQKQAHVILTTACSTAARQGSGPASSSQPAVP 604
                             ..:.|....:.:.|....|..|:   |:|...   ||..|
  Rat   815 -----------------VTETSFTIDELEELYALFKAEHL---TSCYWG---GSSNA-------- 848

  Fly   605 VNQLLLGRPAIVTNKGKRVGAPLGAIPPARKPSLPAVLHTKPTSEKQLRRGETLL--W-----RD 662
                                      |....|||| .|.......:|.:....||  |     .|
  Rat   849 --------------------------PDRHDPSLP-YLEQYRIDFEQFKGMFVLLFPWACGTHSD 886

  Fly   663 TDPSR------RRRDSL-TWKEIKADRAAMIREGVDVSSVRTQKLRTRFGKSDSSSYSEDSDGEQ 720
            ...||      ...||| .::|..:..:|.....:      |:||:..:   ......|.|
  Rat   887 VLASRLFQLLDENGDSLINFREFVSGLSAACHGDL------TEKLKLLY---KMHVLPEPS---- 938

  Fly   721 ESGTGGGGGSSTDTSLCDDDDPKST---------------------EKSPKQKAKLARKLKEQKQ 764
                            ||.|:|.|.                     :...||.|.........||
  Rat   939 ----------------CDQDEPDSAFEATQYFFEDITPECTHVVGLDSRGKQSADEGFVTVSLKQ 987

  Fly   765 LAGSRETSLE-RQRPKSWAPSSHEIPFMLMGTDSGDEKEDKSTKEGP--ITGDQAEDSATESGHY 826
            ..|.|..|.| |...|.|.              :.::.:.|:.|:.|  ..|...|...|....:
  Rat   988 DRGKRANSQENRHYLKLWT--------------AENKSKSKNAKDLPKLNQGQFIELCKTMYNMF 1038

  Fly   827 EFD---RELHLVSSKMEPLKLPFDPEFTGMTSVSPIPTPREKSEAEEDLLDERKPFDVSDDGVTN 888
            ..|   :||:..::.:..|.|..     |......|..|     |:||.:    |.......:..
  Rat  1039 SEDPNEQELYHATAAVTSLLLEI-----GEVGKFFITQP-----AKEDAV----PGPPCSQAIPG 1089

  Fly   889 QYFERVNSVERPNRLELTYSLNEEETDTNAIYLEEREKVEGHSGDREYNSLPPFYPRENDDGVQG 953
            ..|.:..|         :.|...|.||.....|         :||||.:||
  Rat  1090 MLFPKKGS---------SQSYVVESTDPLPASL---------AGDREEHSL-------------- 1122

  Fly   954 GGKVPQIR-DDNIPGEN-------------KDD-----YKELLSMTIEENTVYKPPTPTASTLSN 999
            ||::..|: :|:.|.:|             |||     |..|.:.:.||:.::.......:.|..
  Rat  1123 GGQMEDIKLEDSSPRDNGACSSMLISDDDTKDDSSMSSYSVLSAGSHEEDKLHCEDIGEDTVLVR 1187

  Fly  1000 ASRKRRD-PRRKTLTRSSTIEIEE 1022
            :|:.|.. ||..:|.|...|..|:
  Rat  1188 SSQGRAALPRSSSLDRDWAITFEQ 1211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	54/176 (31%)
		DUF4682	560..689	CDD:464830	27/142 (19%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
Tbc1d9	NP_001402001.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	5/16 (31%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	21/101 (21%)
		TBC	510..720	CDD:214540	67/239 (28%)
		EFh	<891..921	CDD:415501	6/29 (21%)
		RRM_SF	944..1008	CDD:473069	14/77 (18%)