Protein Alignment CG42795 and TBC1D9

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_055945.2
• Gene: TBC1D9 / 23158
• HGNCID: 21710
• Length: 1266
• Species: Homo sapiens
• Alignment Length: 1080
• Identity: 233/1080 - (21%)
• Similarity: 375/1080 - (34%)
• Gaps: 352/1080 - (32%)

  Fly     1 MSETKKLLDAL-------LCDIYG-RQEVLAKRIRRCCRDPVHKRSPKKKKGQLAQLASGMVGDR 57
            ::||.||::.|       |.|..| .|:....:::|        :||||.......|.:....:|
Human   238 INETFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKR--------KSPKKVSALKRDLDARAKSER 294

  Fly    58 -SSLERLDVRKLID---VCAILKVEILMLGYLLERVLVARDRL--QRHQEVLCEFV---TAVLIV 113
             .:|.||...:.:|   .|.:......|  ::|.::.|:.:.:  ...:|.||..:   ..|.||
Human   295 YRALFRLPKDEKLDGHTDCTLWTPFNKM--HILGQMFVSTNYICFTSKEENLCSLIIPLREVTIV 357

  Fly   114 ESDDAQPKMRFSLSPPPQKAITSARLT--------------------SPTKNSLSSNNTITTPGS 158
            |..|:.     |:.|.|....|..|:|                    ..|.:.:.|:....  ||
Human   358 EKADSS-----SVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFA--GS 415

  Fly   159 NNRSPSS--TKTTMLTRNGGGHGTSPTASG------SGHA-PSATAA--------ADDEAT---- 202
            .|.|...  ::.:.|..:.....||..|.|      :|:: |:||..        :.:|..
Human   416 YNSSDDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSPEEFNPKLA 480

  Fly   203 -------------SDYNQWL------HAMKLVARLPGGTPPEFRRKLWLSLADKYLKSKNVDWAQ 248
                         ::|.|.:      ...:||.:   |.|...|.:|||.|:...
Human   481 KEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLK---GIPESMRGELWLLLSGAI---------- 532

  Fly   249 QREKCFCEEWRED--DEELG------IQIVKDLHRTGSNLCTGPA--GSINQAKLKRILLGYARY 303
             .||.....:.||  ::.:|      .:|.:||||   :|...||  ..:..|.|:|:|..||..
Human   533 -NEKATHPGYYEDLVEKSMGKYNLATEEIERDLHR---SLPEHPAFQNEMGIAALRRVLTAYAFR 593

  Fly   304 NPEVGYCQGFNMLGALILQVMDKEEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQT 368
            ||.:||||..|::.:::|  :..:|||:..:::.|.|.:|| .|:...:.|...|.|||.||.:.
Human   594 NPNIGYCQAMNIVTSVLL--LYAKEEEAFWLLVALCERMLP-DYYNTRVVGALVDQGVFEELARD 655

  Fly   369 RLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTA 433
            .:|:|...:|.|          .:.:..::.||||:|.:.:|....:.|.|....||..|:.:.|
Human   656 YVPQLYDCMQDL----------GVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLA 710

  Fly   434 LVLWSLLEERVISVRSADEFYGKMGSYSSELLN--------GHLVDSNGLIERVVKLGPIEDL-R 489
            |.:.....:::::.:...|....:|.|...:.|        .||   :.|:...|:..|..|: |
Human   711 LAVLDANVDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHL---HSLLSDDVEPYPEVDIFR 772

  Fly   490 QLRDKHLYN---------IAPLRHKQGLQLYYDEEDTHSDEERLAVATV-----FGLN------- 533
            .:|..  |.         |..:|.||.|::....|||   .:|..|.|:     |.::
Human   773 LIRTS--YEKFGTIRADLIEQMRFKQRLKVIQTLEDT---TKRNVVRTIVTETSFTIDELEELYA 832

  Fly   534 -----------WGRRGS------------------------------VGPAAAGKQQVEQKDRLA 557
                       ||  ||                              :.|.|.|........||
Human   833 LFKAEHLTSCYWG--GSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRL- 894

  Fly   558 LDISLLKKQYDRL---RE----RQKQAHVILTTACSTAARQGSGPASSSQPAVPVNQL------- 608
              ..||.:..|.|   ||    .....|..||.......:....|..||....|.:..
Human   895 --FQLLDENGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFF 957

  Fly   609 ---------LLGRPAIVTNKGKRVGAPLGAIPPARKPSLPAVLHTKPTSEKQLRRGETLLWRDTD 664
                     ::|    :.::.|: ||..|.:..:.||.      ....:..|..|....||...:
Human   958 EDITPECTHVVG----LDSRSKQ-GADDGFVTVSLKPD------KGKRANSQENRNYLRLWTPEN 1011

  Fly   665 PSRRRRDSLTWKEIKADRAAMIREGVDVSSVRTQKLRTRFGKSDSSSYSEDSD------------ 717
            .|:.:         .|.....:.:|..:...:|.          .:.:|||.:
Human  1012 KSKSK---------NAKDLPKLNQGQFIELCKTM----------YNMFSEDPNEQELYHATAAVT 1057

  Fly   718 ------GE----------QESGTGGGGGSSTDTSLCDDDDP---------------KSTEKSPKQ 751
                  ||          :|.|:||.|.|      |....|               :|.|..|
Human  1058 SLLLEIGEVGKLFVAQPAKEGGSGGSGPS------CHQGIPGVLFPKKGPGQPYVVESVEPLP-- 1114

  Fly   752 KAKLARKLKEQKQLAGSRE-TSLERQRPK-SWAPSSHEIPFMLMGTDSGDEKEDKSTKEGPITGD 814
             |.||.. .|:..|.|..| ..||...|: :.|.||     ||:..|  |.|:|.|
Human  1115 -ASLAPD-SEEHSLGGQMEDIKLEDSSPRDNGACSS-----MLISDD--DTKDDSS--------- 1161

  Fly   815 QAEDSATESGHYEFDRELH---------LVSSKMEPLKLP 845
            .:..|...:|.:|.|: ||         ||.|......||
Human  1162 MSSYSVLSAGSHEEDK-LHCEDIGEDTVLVRSGQGTAALP 1200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	54/176 (31%)
		DUF4682	560..689	CDD:464830	26/151 (17%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
TBC1D9	NP_055945.2	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	5/16 (31%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	19/101 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..456		9/40 (23%)
		TBC	512..722	CDD:214540	67/239 (28%)
		EFh	<893..923	CDD:415501	9/32 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1075..1095		8/25 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1132..1164		13/47 (28%)