Protein Alignment CG42795 and SGSM1

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_001035037.1
• Gene: SGSM1 / 129049
• HGNCID: 29410
• Length: 1148
• Species: Homo sapiens
• Alignment Length: 1159
• Identity: 214/1159 - (18%)
• Similarity: 348/1159 - (30%)
• Gaps: 448/1159 - (38%)

  Fly   469 LVDS-----NGLIERVVKLGPIEDLRQLRDKHLYNIAPLRHK----------QGLQLYYDEEDTH 518
            |::|     .||.|.|.||..:.:|..|..|||:....|..|          :....||::|...
Human    97 LIESARNQIQGLQENVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALL 161

  Fly   519 SDE-ERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLLKKQYDRL--RERQKQAHVI 580
            .|. :...:|::.         |||.|....:::..|....|.|.     |.|  |.|...:||.
Human   162 MDPVDGPILASLL---------VGPCALEYTKMKTADHFWTDPSA-----DELVQRHRIHSSHVR 212

  Fly   581 LTTACSTAA-----RQGSG-----PASSSQPAV-PVNQ-----LLLGRPAIVTNKGKRVGAPLGA 629
            ..:.....|     |..||     |:.|::..| .::|     ||.|:..::..
Human   213 QDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQ----------- 266

  Fly   630 IPPARKPSLPAVLHTKPTSEKQLRRGETLLWRDTDPSRRRRDSLTW-KEIKADRAAMIR------ 687
             |.....::|..|....|::..     ||.|............|.: |.:..|.|..||
Human   267 -PRDDMEAVPGYLSLHQTADVM-----TLKWTPNQLMNGSVGDLDYEKSVYWDYAMTIRLEEIVY 325

  Fly   688 ----EGVD-------VSSVRTQKLRTRFGKSDSSSYSEDSDGEQESGTGGGGGSSTDTSLCDDD- 740
                :.||       ||....|:...||.|                     ||.......|.::
Human   326 LHCHQQVDSGGTVVLVSQDGIQRPPFRFPK---------------------GGHLLQFLSCLENG 369

  Fly   741 -------DPKSTEKSPKQKAKLARKLKEQKQLAGSRETSLERQRPKSWAPSSHEIPFMLMGTDSG 798
                   ||...  |.:.|.|:..||:::.....:..||
Human   370 LLPHGQLDPPLW--SQRGKGKVFPKLRKRSPQGSAESTS-------------------------- 406

  Fly   799 DEKEDKSTKEGPITGDQAEDSATESGHYEFDRELHLVSSKMEPLKLPFDPEFTGMT---SVSP-- 858
                          .|:.:|.||:   |.|    .::...|:...:.  |:|.|.|   ||.|
Human   407 --------------SDKDDDEATD---YVF----RIIYPGMQSEFVA--PDFLGSTSSVSVGPAW 448

  Fly   859 --IPTPREKSEAEEDLLDERKPFDVSDDGVTNQYFERVNSVERPNRLELTYSLNEEETDTNAIYL 921
              :|..|..      |:..|                  .|...|.|.:.|
Human   449 MMVPAGRSM------LVVAR------------------GSQWEPARWDTT--------------- 474

  Fly   922 EEREKVEGHSGDREYNSLPPFYPRENDDGVQGGGKVPQIRDDNIPGENKDDYKELLSMTIEENTV 986
                             ||...|:|..       .:||               :|:.:::.....
Human   475 -----------------LPTPSPKEQP-------PMPQ---------------DLMDVSVSNLPS 500

  Fly   987 YKPPTPTASTLSNASRK-------------RRDPRRKTLTRSSTIEIEERYQALERR-------- 1030
            ...|:|..|:.|:.|:.             .|.|.:......       :||.|.|.
Human   501 LWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNM-------KYQILSRAFYGWLAYC 558

  Fly  1031 ------------------ISQDQPSGDRQA-------KYIPSTAALEER-------FNTLEKQL- 1062
                              :|.|.|....|.       :|:..:.:.||:       :..::.::
Human   559 RHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQELLRLIYYGGIQPEIR 623

  Fly  1063 --------------SAEKQRKELSEM--------EAEYPIKSERIPSTADLESRFNSLTKQMSSS 1105
                          ..|.:|||:.|.        .||: :..|.|....:.||...:|.|..|.:
Human   624 KAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEW-LGCEAIVRQRERESHAAALAKCSSGA 687

  Fly  1106 ESSSKTPIDLKDEDRPSGSSSKNQKDSEKTSKLHKSEEPESNTKETTGETEASDSNDSKIGEKET 1170
            ...|.....|..:...|..||::.....:..:||......:...|:..|.|..::.    |..|.
Human   688 SLDSHLHRMLHRDSTISNESSQSCSSGRQNIRLHSDSSSSTQVFESVDEVEQVEAE----GRLEE 748

  Fly  1171 EQPRIKKLPSTAELEDRFNALERKMSVQKSSPSKNKKEPPDEEESKSTKEPEEPEESEKANEKTS 1235
            :||   |:|:.              ::...:.|.:...|.....|....|..||..|.:.:...:
Human   749 KQP---KIPNG--------------NLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVLDA 796

  Fly  1236 GRQTP--IAKKDSKDSDQKKSETKENQSPTKNQDEKVKVKSPKSEEMIEKETSSNPKEDSHESEA 1298
            .|.||  :..:|....|::.||.      |.:|||     :|:.|..:         :||.||:.
Human   797 QRNTPTVLRPRDGSVDDRQSSEA------TTSQDE-----APREELAV---------QDSLESDL 841

  Fly  1299 ATNKKVEGNRELSSEKG--DHKIKEKSEEAPGKAGKETAETKNANVKDSSKKGDSQKNEAAKTSV 1361
            ..|:.::   |..|..|  |..:.||.:..  ..|..::||:.....||
Human   842 LANESMD---EFMSITGSLDMALPEKDDVV--MEGWRSSETEKHGQADS---------------- 885

  Fly  1362 SQTESDLKPSSKENSTSKDAEQEKTPRKSPPSTEELEKRFNALEKQMSTTNLETTKEPDQTKPAT 1426
                        |::.|::              .|:|..|.||      .:|..|...::..|.:
Human   886 ------------EDNLSEE--------------PEMESLFPAL------ASLAVTTSANEVSPVS 918

  Fly  1427 KSQST-SAEVKTQKSMKSFDDKIKEVNV-AIEKEQSRVE------VEVNAEKKR 1472
            .|..| |.|:.          .:..||: .|||:..|.:      ...|.||.|
Human   919 SSGVTYSPELL----------DLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLR 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855
		DUF4682	560..689	CDD:464830	31/157 (20%)
		PTZ00121	<1112..2009	CDD:173412	75/373 (20%)
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
SGSM1	NP_001035037.1	RUN_SGSM1	20..196	CDD:439065	26/107 (24%)
		PH_RUTBC	254..425	CDD:275431	42/257 (16%)
		Important for interaction with RAB9A and RAB9B. /evidence=ECO:0000250|UniProtKB:Q8BPQ7	256..297		10/57 (18%)
		Required for interaction with RAP family members	301..350		11/48 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..411		10/75 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	700..830		33/161 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	871..894		7/64 (11%)
		TBC	<936..1105	CDD:214540	8/27 (30%)