Protein Alignment CG42795 and EVI5L

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_001153416.1
• Gene: EVI5L / 115704
• HGNCID: 30464
• Length: 805
• Species: Homo sapiens
• Alignment Length: 1074
• Identity: 225/1074 - (20%)
• Similarity: 367/1074 - (34%)
• Gaps: 369/1074 - (34%)

  Fly   125 SLSP--PPQKAITSARLTSPTKNS--LSSN--NTITTPGSNNRSPSSTKTTMLTRNGGGHGTSPT 183
            :|||  ..|:|: ||...|||.:|  ||.:  ..:......||...:...:|.:.||     |..
Human     5 TLSPDSSSQEAL-SAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNG-----SRR 63

  Fly   184 ASGSGHAPSATAAAD----DEAT--------SDYNQWLHAM-KLVARL-PGGTPPEFRRKLW--- 231
            .|||....|::|:::    :|.|        :::.:|.... ||:..| ..|.|..||..:|
Human    64 NSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLL 128

  Fly   232 LSLADKYLKSKNVDWAQQREKCFCEEWREDDEELGIQIVKDLHRT--------GSNLCTGPAGSI 288
            .|..|..:|::..:..:....|         |:|   |.:|:.||        |.:       |:
Human   129 CSATDMPVKNQYSELLKMSSPC---------EKL---IRRDIARTYPEHEFFKGQD-------SL 174

  Fly   289 NQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMKVMIYLVEGVLPTGYFYGSMG 353
            .|..|..::..|:..:.|||||||...:..|:|  |...|||:..|.:.|::.......|..||.
Human   175 GQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLL--MQMPEEEAFCVFVRLMQEYRLRELFKPSMA 237

  Fly   354 GLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLRVW 418
            .|...:..|..::|.:||.|..|.:      ..:|.   |:::...||||:|.|..|:....||:
Human   238 ELGLCIYQFEYMLQEQLPDLNTHFR------SQSFH---TSMYASSWFLTLFLTTFPLPVATRVF 293

  Fly   419 DLVLIEGSDVLLRTALVLWSLLEERVISVRSADEFYGKMGSYSSELLNGHLVDS--NGLIERV-- 479
            |:.:.||.:::.|..|.|..:.:..::.:    :..| |..|...:: .|..||  :.|:.:.
Human   294 DIFMYEGLEIVFRVGLALLQVNQAELMQL----DMEG-MSQYFQRVI-PHQFDSCPDKLVLKAYQ 352

  Fly   480 VKLGPIEDLRQLRDKHLYNIAPLRHKQGLQLYYDEEDTH----SDEERLAVATVFGLNWGRRGSV 540
            ||..| :.:::|..::    |.::.|:      .||...    ..|.||.
Human   353 VKYNP-KKMKRLEKEY----AAMKSKE------MEEQIEIKRLRTENRLL--------------- 391

  Fly   541 GPAAAGKQQVE--QKDRLALDISLLKKQYDRLRERQ-----KQAHVILTTACSTAARQGSGPASS 598
                  ||::|  :|:..||...|::.|..|.:|.:     |:...::...||:||..    ...
Human   392 ------KQRIETLEKESAALADRLIQGQVTRAQEAEENYVIKRELAVVRQQCSSAAED----LQK 446

  Fly   599 SQPAVPVNQLLLGRPAIVTNKGKRVGAPLGAIPPARKPSLPAVLHTKPTSEK-QLRRGETL-LWR 661
            :|..:...|.....|.:..:                     .|.|.:...|: :||..||| ..|
Human   447 AQSTIRQLQEQQENPRLTED---------------------FVSHLETELEQSRLRETETLGALR 490

  Fly   662 DTDPS----RRRRDSL--------TWKEIKADRAAMIREGVDVSSVRTQKLRTRFGKSDSSSYSE 714
            :....    .:|..||        ..:|:|   |..:|||..|:|.|..||:.:          |
Human   491 EMQDKVLDMEKRNSSLPDENNVAQLQEELK---ALKVREGQAVASTRELKLQLQ----------E 542

  Fly   715 DSDGEQESGTGGGGGSSTDTSLCDDDDPKSTEKSPKQKAKLARKLKEQKQLAGSRETSLERQRPK 779
            .||..|.....||...         :.|:.......|...::.:|:|.:.||..||.   |||.
Human   543 LSDTWQAHLARGGRWK---------ESPRKLVVGELQDELMSVRLREAQALAEGREL---RQRV- 594

  Fly   780 SWAPSSHEIPFMLMGTDSGDEKEDKSTKEGPITGDQAEDSATESGHYEFDRELHLVSSKMEPLKL 844
                                                          .|.:.:.|:..:.:
Human   595 ----------------------------------------------VELETQDHIHRNLL----- 608

  Fly   845 PFDPEFTGMTSVSPIPTPREKSEAEEDLLDERKPF-DVSDDGVTNQYFERVNSVERPNRLELTYS 908
                               .:.|||...|.|:..: ...:.|:..|..|     .|..:.|....
Human   609 -------------------NRVEAERAALQEKLQYLAAQNKGLQTQLSE-----SRRKQAEAECK 649

  Fly   909 LNEE-------ETDTNAIYLEEREKV--------EG-------HSGDREYNSLPPFYPRENDDGV 951
            ..||       |.|:.|...|.|:::        ||       ||...:|
Human   650 SKEEVMAVRLREADSMAAVAEMRQRIAELEIQREEGRIQGQLNHSDSSQY--------------- 699

  Fly   952 QGGGKVPQIRDDNIPGENKDDYKELLSMTIEENTVYKPPTPTASTLSNASRKRRDPRRKTLTRSS 1016
                    ||      |.||..:||.:    |..:.|.|.|....|:...
Human   700 --------IR------ELKDQIEELKA----EVRLLKGPPPFEDPLAFDG--------------- 731

  Fly  1017 TIEIEERYQALERRISQDQ-PSGDRQAKYIPSTAALEERFNTLEKQLSAEKQRKELSEMEAEYPI 1080
                    .:|.|.:.:|. ||.|.:...:...|||:                      :|.||:
Human   732 --------LSLARHLDEDSLPSSDEELLGVGVGAALQ----------------------DALYPL 766

  Fly  1081 KSERIPSTADLESRFNSLTKQMSSSESSSKTPID 1114
            .    |..|..   |..|.:....||.||.:..|
Human   767 S----PRDARF---FRRLERPAKDSEGSSDSDAD 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	51/182 (28%)
		DUF4682	560..689	CDD:464830	28/147 (19%)
		PTZ00121	<1112..2009	CDD:173412	1/3 (33%)
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
EVI5L	NP_001153416.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		13/31 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..75		8/30 (27%)
		TBC	112..320	CDD:214540	62/237 (26%)
		Smc	<363..>762	CDD:440809	111/633 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	777..805		6/17 (35%)