DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42795 and TBC1D8

DIOPT Version :10

Sequence 1:NP_001287272.1 Gene:CG42795 / 41252 FlyBaseID:FBgn0261928 Length:3213 Species:Drosophila melanogaster
Sequence 2:NP_001317277.1 Gene:TBC1D8 / 11138 HGNCID:17791 Length:1155 Species:Homo sapiens


Alignment Length:423 Identity:105/423 - (24%)
Similarity:172/423 - (40%) Gaps:104/423 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   213 KLVARLPGGTPPEFRRKLWLSLADKY--LKSKNVDWAQQREK-----CFCEEWREDDEELGIQIV 270
            ||||.   |.|...|.:|||..:|..  |.|....:....|:     |...|          :|.
Human   515 KLVAM---GIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTE----------EIE 566

  Fly   271 KDLHRTGSNLCTGPA--GSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMK 333
            :||||   :|...||  .....|.|:|:|..||..||::||||..|:|.:::|  :..:|||:..
Human   567 RDLHR---SLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLL--LYTKEEEAFW 626

  Fly   334 VMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTM 398
            :::.:.|.:|| .||...:.|.|.|..||.||::..||.||:|:..|..         |.:| ::
Human   627 LLVAVCERMLP-DYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSA---------LASV-SL 680

  Fly   399 QWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVISVRSADEFYGKMGSYSSE 463
            .||||:|.:.:|:...:.|.|....:|...:.:..|.:.....|.:.|.:...:....:..:...
Human   681 SWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQALMILSRFLDH 745

  Fly   464 LLNGHLVDSNGLIERVVKLG-------------PIEDLRQL--------RDKHLYNIAPLRHKQG 507
            :.|   .||.|     ..:|             |:.|:..|        .|:.:..|..||:|..
Human   746 IKN---EDSPG-----PPVGSHHAFFSDDQEPYPVTDISDLIRDSYEKFGDQSVEQIEHLRYKHR 802

  Fly   508 LQLYYDEEDTHSDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLAL-DISLLKKQYDRLR 571
            :::....|||                            .||.|.   |:.: ::|:|.:..:.|.
Human   803 IRVLQGHEDT----------------------------TKQNVL---RVVIPEVSILPEDLEELY 836

  Fly   572 ERQKQAHVILTTACSTAARQGSGPASSSQPAVP 604
            :..|:.|::     |....|....||...|:.|
Human   837 DLFKREHMM-----SCYWEQPRPMASRHDPSRP 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42795NP_001287272.1 RabGAP-TBC 268..443 CDD:459855 56/176 (32%)
DUF4682 560..689 CDD:464830 11/45 (24%)
PTZ00121 <1112..2009 CDD:173412
PTZ00121 <1740..2340 CDD:173412
PTZ00449 <2270..2610 CDD:185628
TBC1D8NP_001317277.1 PH-GRAM1_TBC1D8 171..269 CDD:270156
PH-GRAM2_TBC1D8 311..406 CDD:270160
TBC 520..726 CDD:214540 69/231 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1046..1085
Blue background indicates that the domain is not in the aligned region.

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