DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42795 and Tbc1d10c

DIOPT Version :10

Sequence 1:NP_001287272.1 Gene:CG42795 / 41252 FlyBaseID:FBgn0261928 Length:3213 Species:Drosophila melanogaster
Sequence 2:NP_848765.2 Gene:Tbc1d10c / 108995 MGIID:1922072 Length:444 Species:Mus musculus


Alignment Length:572 Identity:137/572 - (23%)
Similarity:203/572 - (35%) Gaps:183/572 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 NSLSSNNTITTPGSNNRSPSSTKTTMLTRNG--GGHGTSPTASGSGH----APSATAAADDEATS 203
            :||.|::.::.|....::         .|.|  ||:        ||.    .|||......|.  
Mouse    18 SSLGSDSELSGPSPYRQA---------DRYGFIGGN--------SGELRLCQPSADLIRQREM-- 63

  Fly   204 DYNQW----LHAMKLVAR--------LPGGTPPEFRRKLWLSLADKYLKSKNVDWAQQREKCF-- 254
               :|    ||..|.::|        ...|.|...|.:.|..|....:..||.....|.....  
Mouse    64 ---KWVEMTLHWEKTMSRRYKKVKIQCRKGIPSALRARCWPLLCGARMCQKNNPGTYQELAAAPG 125

  Fly   255 CEEWREDDEELGIQIVKDLHRTG--SNLCTGPAGSINQAKLKRILLGYARYNPEVGYCQGFNMLG 317
            ..:|.|       .|.:||||..  ..:...|.|. .|..|.::|..|..|.||.||||....:.
Mouse   126 DPQWME-------TIGRDLHRQFPLHEMFVSPQGH-GQQGLLQVLKAYTLYRPEQGYCQAQGPVA 182

  Fly   318 ALILQVMDKEEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRL-Q 381
            |::|  |....||:...::.:.|..|| ||:...|..:|.|..||..|::.:|||:.||||:: .
Mouse   183 AVLL--MHLPPEEAFWCLVQICEVYLP-GYYGPHMEAVQLDAEVFMALLRRQLPRVYKHLQQVGV 244

  Fly   382 GPVENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVIS 446
            ||:          ::..:|||.:|...||...|||:||..|.||:.||.|..|.|..|       
Mouse   245 GPL----------LYLPEWFLCLFTRSLPFPTVLRIWDAFLSEGAKVLFRVGLTLMRL------- 292

  Fly   447 VRSADEFYGKMGSYSSELLNGHLVDSNGLIE-RVVKLGPIEDLRQLRDKHLYNIAPLRHKQGLQL 510
                                     :.|.:| |....|.:|.|..||     .|.|         
Mouse   293 -------------------------ALGTVEQRTACPGLLETLGALR-----AIPP--------- 318

  Fly   511 YYDEEDTHSDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLLKKQYDRLRERQK 575
                  |...||      ||      ...|......::.::|:.|:.|                 
Mouse   319 ------TQLQEE------VF------MSQVHSVTLSERVLQQEIRIQL----------------- 348

  Fly   576 QAHVILTTACSTAARQGSGPASSSQPAVPVNQLLLGRPAIVTNKGKRVGAPLGAIPPARKPSLPA 640
                      :..::...|||...|..:|      |..||..::      .|..:..:.||.:|.
Mouse   349 ----------AQLSKSLPGPAPLPQARLP------GAQAIFESQ------QLAGVRESTKPEIPR 391

  Fly   641 VL-----HTKPTSEKQLRRGET---LLWRD-----TDPSRRRRDSLTWKEIK 679
            ::     ..||...|...||:|   ||.|.     ..|||.:|.|.::.:.:
Mouse   392 IVVQPPEEPKPPRRKPQTRGKTFHGLLIRARGPPIEGPSRSQRGSASFLDTR 443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42795NP_001287272.1 RabGAP-TBC 268..443 CDD:459855 63/177 (36%)
DUF4682 560..689 CDD:464830 26/133 (20%)
PTZ00121 <1112..2009 CDD:173412
PTZ00121 <1740..2340 CDD:173412
PTZ00449 <2270..2610 CDD:185628
Tbc1d10cNP_848765.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 4/13 (31%)
TBC 87..292 CDD:214540 72/225 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..444 17/61 (28%)
Interaction with calcineurin. /evidence=ECO:0000250 404..444 12/40 (30%)
Blue background indicates that the domain is not in the aligned region.

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