DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAN2B1 and LManI

DIOPT Version :9

Sequence 1:	XP_005259970.1	Gene:	MAN2B1 / 4125	HGNCID:	6826	Length:	1012	Species:	Homo sapiens
Sequence 2:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster

Alignment Length:	989	Identity:	423/989 - (42%)
Similarity:	574/989 - (58%)	Gaps:	81/989 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    62 MLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSR 126
            |:||||:||:|||||||||||||:||.:|.|||||||||||:|:..||.|.:||||.||..||::
  Fly     1 MINVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAK 65

Human   127 WWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRV 191
            |:.:||...|..|:.||.|||||||.|.|.|||||..||.::|||..||||:|:||||:.|||.|
  Fly    66 WYSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTV 130

Human   192 AWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGV 256
            .|.|||||||||.||:||||.|:|.||.|:||.||..||..||||.:|::|.|||  .:::|||:
  Fly   131 GWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLK--NSNIFTGM 193

Human   257 LPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQ 321
            |.|.|:.|...|:|:.|.|.|:: |..|.:.|....|..|::......:.||:.|.::.||.|||
  Fly   194 LYNHYSAPPGFCFDINCEDAPII-DGESYDNNVDARVSEFIDYVKNMSKSYRSTHIMVPMGDDFQ 257

Human   322 YENANMWFKNLDKLIRLVNAQQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPH 386
            ||:|.:.|||:||||:.|| .:|:.||.|:|.||||:|||:||::...||..|.:|||||:...|
  Fly   258 YEDAAVNFKNMDKLIKYVN-DRQSTGSQVNVFYSTPSCYLYELHQLKQTWPNKTEDFFPYSSDSH 321

Human   387 QFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVS 451
            .:|||||:|||..||:.|...:|.|...||..|..|:   |...|.|...|::||.::||||||:
  Fly   322 SYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLS---GTQYSEDLDNLSQAMGIMQHHDAVT 383

Human   452 GTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGF-KDHFTFCQQLNISICPLSQ-TAARFQVI 514
            ||.:|.||:||.|.|.......|....:||..|... ...|..|.:||||:|..:| ||....|.
  Fly   384 GTEKQAVASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFESCLELNISVCAFTQDTANNVIVT 448

Human   515 VYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFP---------SSDSQAHPPELLFSAS 570
            :.|||.......||:|.....::|.|..||.|.|:||..|         .:|:| |  ||:|.||
  Fly   449 LVNPLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQ-H--ELVFEAS 510

Human   571 LPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLL 635
            :..:  :.:.:..:|..|..|......|.......||:|...::.|||..||.| :.:.|| ...
  Fly   511 VDKI--ANFLIRVLPSPKNIAEDQVQFPVERSQDELTVETSLVKLTFDTTTGGL-KTVKMN-GFT 571

Human   636 LPVRQTFFWYNASIGDN--ESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPL---------VQE 689
            ..::|||..|....|:|  ..:::||||:|||          :..|.:|...:         |:|
  Fly   572 ENIQQTFGIYKGYRGNNGESKNRSSGAYVFRP----------YGDIEIVNNKVELSFYNGTKVKE 626

Human   690 VHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREIL 754
            |||:.:.|.|||:|:|.....:|.||.|||||..|..|||:|:||.:.:.:||:|||||||||||
  Fly   627 VHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREIL 691

Human   755 ERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLL 819
            ||.|:.|..:..:.:|.::||||||..:|.:.|...::|:|.||:|||:||:||.||||:|||||
  Fly   692 ERERNQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLL 756

Human   820 KDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAGHRLLAEQ-EVLAPQVVLAPGGGAAYN 881
            .||..||.|.|.|.  |:|...||:..::|| |.......|||..| :....:......|.|:.|
  Fly   757 NDDAFGVGEALNETQYGTGLIARGKIYLILD-AVDGKPNQRLLQHQLDQHFWKFFSKSNGVASVN 820

Human   882 LGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFST 946
            ....|  .|.|    :|.||.||:|..:..:.:|:|||:....|.        .|:.|:..||.:
  Fly   821 RNMIP--DFFG----IPESVELLSLEPYSKDQILIRLENFNTEGN--------VVSFNIYPLFES 871

Human   947 FTITRLQETTLVANQLREAASRLKWTTN-TGPTPHQTPYQLDPAN--------------ITLEPM 996
            ....::.||||..|.|.|...|.|:..: ||..|....|...|.|              :||.||
  Fly   872 LDGYQIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVTLVPM 936

Human   997 EIRTFLASVQWKEV 1010
            :||||:  :|.|.:
  Fly   937 QIRTFI--IQQKYI 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAN2B1	XP_005259970.1	PLN02701	63..1001	CDD:178304	418/977 (43%)
		GH38N_AMII_LAM_like	63..341	CDD:212121	156/277 (56%)
		Alpha-mann_mid	388..466	CDD:214875	37/77 (48%)
		Glyco_hydro_38C	511..1001	CDD:285047	186/527 (35%)
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	155/276 (56%)
		Alpha-mann_mid	323..398	CDD:286360	37/77 (48%)
		Glyco_hydro_38C	536..941	CDD:285047	159/431 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I684
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	811	1.000	Inparanoid score	I487
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm40555
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790