DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Timp and timp2b

DIOPT Version :9

Sequence 1:	NP_731461.1	Gene:	Timp / 41248	FlyBaseID:	FBgn0025879	Length:	210	Species:	Drosophila melanogaster
Sequence 2:	NP_998461.1	Gene:	timp2b / 406650	ZFINID:	ZDB-GENE-040426-2655	Length:	217	Species:	Danio rerio

Alignment Length:	216	Identity:	52/216 - (24%)
Similarity:	90/216 - (41%)	Gaps:	31/216 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLRKHLGLLTLLLVAVFAFYGRPADACSCMPSHPQTHFAQADYVVQLRVLRKSDTIEPGRTTYK 65
            |.:.:.:.||.|:|.....|.|    ||||.|.|||..:..||.|::.:|:.:.:.: .|...|.
Zfish     1 MSMSRSVPLLLLVLCGATDFAG----ACSCSPEHPQQAYCNADVVIRAKVVGRKEVV-TGNDAYG 60

  Fly    66 VHIKRTYKATSEARRMLR--DGRLS---TPQDDAMCGINLDL-GK-VYIVAGRMPT-----LNIC 118
            ..|| ..:...:..:|.:  :|.:.   |....|:||:||:. || .|::.|.:.:     :|:|
Zfish    61 YPIK-MIRYDVKQLKMFKGPNGEIDTIFTGPSSALCGVNLESNGKQEYLITGNLNSNGTLRINLC 124

  Fly   119 SYYKEYTRMTITERHGFSGGY-----AKATNCTVTPCFGERCFKGRNYADTCKWSPFGKCETNYS 178
            .|.:.:..:::|::......|     .|...|.:.||       ..:....|.|:.: ..|....
Zfish   125 DYIESWESLSLTQKKSLGPRYQMGCDCKIVQCPIIPC-------SISEPVECLWTDW-VLEGTVQ 181

  Fly   179 ACMPHKVQTVNGVISRCRWRR 199
            .........|....|.|.|.|
Zfish   182 GTQAQHYTCVKRSDSSCAWYR 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Timp	NP_731461.1	TIMP	26..197	CDD:279332	43/187 (23%)
timp2b	NP_998461.1	TIMP	23..200	CDD:279332	43/186 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586887
Domainoid	1	1.000	74	1.000	Domainoid score	I9074
eggNOG	1	0.900	-	-		E1_KOG4745
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	75	1.000	Inparanoid score	I5261
OMA	1	1.010	-	-		QHG47496
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000998
OrthoInspector	1	1.000	-	-		otm24223
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11844
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X655
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.860