DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Timp and timp2a

DIOPT Version :9

Sequence 1:	NP_731461.1	Gene:	Timp / 41248	FlyBaseID:	FBgn0025879	Length:	210	Species:	Drosophila melanogaster
Sequence 2:	NP_878294.1	Gene:	timp2a / 359835	ZFINID:	ZDB-GENE-030612-1	Length:	220	Species:	Danio rerio

Alignment Length:	216	Identity:	55/216 - (25%)
Similarity:	98/216 - (45%)	Gaps:	33/216 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LRKHLGLLTLLLVAVFAFYGRPADACSCMPSHPQTHFAQADYVVQLRVLRKSDTIEPGRTTYKVH 67
            :|..:|  ||:::.:|. .|..|:||||.|.|||..|..||.|::.:|:.|.: ::.|...|...
Zfish     4 VRSCIG--TLVVLVLFR-VGEIAEACSCSPVHPQQAFCNADVVIRAKVVGKKE-VDSGNDIYGNP 64

  Fly    68 IKRTYKATSEARRMLRDGR----LSTPQDDAMCGI-NLDLG--KVYIVAGRMPT-----LNICSY 120
            |||......:.:......|    :.|....|:||: |||..  |.|:::|:...     :.:|..
Zfish    65 IKRIQYEIKQIKMFKGPDRHIDVVFTAPSSAVCGVTNLDTNGKKEYLISGKAEANGKMHVTLCDL 129

  Fly   121 YKEYTRMTITERHGFSGGYAKATNCTVTPCFGERCFKGRNYADTCKWSPF-------GKCETNYS 178
            ...:..|:.|::...|..|....:|.:|.|....|  ..:..:.|.|:.:       |: ::::.
Zfish   130 IMPWESMSATQKKSLSQRYQMGCDCKITRCATFPC--EISAPEECLWTDWVTEKIIHGR-QSDHY 191

  Fly   179 ACMPHKVQTVNGVISRCRWRR 199
            ||    ::..:|   .|.|.|
Zfish   192 AC----IKRGDG---SCAWYR 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Timp	NP_731461.1	TIMP	26..197	CDD:279332	46/189 (24%)
timp2a	NP_878294.1	NTR_TIMP	26..209	CDD:239640	47/191 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586888
Domainoid	1	1.000	74	1.000	Domainoid score	I9074
eggNOG	1	0.900	-	-		E1_KOG4745
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	75	1.000	Inparanoid score	I5261
OMA	1	1.010	-	-		QHG47496
OrthoDB	1	1.010	-	-		D1122531at2759
OrthoFinder	1	1.000	-	-		FOG0000998
OrthoInspector	1	1.000	-	-		otm24223
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11844
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X655
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.870