DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Timp and timp4.1

DIOPT Version :9

Sequence 1:	NP_731461.1	Gene:	Timp / 41248	FlyBaseID:	FBgn0025879	Length:	210	Species:	Drosophila melanogaster
Sequence 2:	XP_005172816.1	Gene:	timp4.1 / 101882922	ZFINID:	ZDB-GENE-100603-1	Length:	229	Species:	Danio rerio

Alignment Length:	207	Identity:	54/207 - (26%)
Similarity:	99/207 - (47%)	Gaps:	31/207 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GLLTLLLVAVFAFYGRPADACSCMPSHPQTHFAQADYVVQLRV----LRKSDTIEP----GRTTY 64
            |||..:.|.:   ..:..:||||..:|||..|..||.|::..:    :|:.:.|.|    |:..|
Zfish    18 GLLFFMCVCL---NQQMLEACSCASAHPQQLFCSADAVLRAEITGEKIRRREDINPMYGLGKIQY 79

  Fly    65 KVHIKRTYKATSEARRMLRDGRLSTPQDDAMCGINLDLGKVYIVAGRMPT----LNICSYYKEYT 125
            :|.:.:.:|.:...:.:   ..:.|.:..:||||.|:.|: |:::|.|.:    :.:|.:.:.:.
Zfish    80 EVQVIKVFKGSDRIKDL---QHVYTHEMSSMCGIRLNRGQ-YLLSGSMMSEGFFVTLCDFVEHWD 140

  Fly   126 RMTITERHGFSGGYAKATNCTVTPCFGERCF-KGRNYADTCKWS---PFGKCETNYS-ACMPHKV 185
            |:::|::......|....|||::.|..:.|. |.:|......||   ||...|..:. ||:.|.
Zfish   141 RLSLTQKKNLKYRYQMGCNCTISICTEQPCHPKVKNECILTDWSSLWPFEDGEPVHEYACIRHS- 204

  Fly   186 QTVNGVISRCRW 197
               :|   .|.|
Zfish   205 ---DG---SCSW 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Timp	NP_731461.1	TIMP	26..197	CDD:279332	49/187 (26%)
timp4.1	XP_005172816.1	NTR_TIMP	35..216	CDD:239640	49/187 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9074
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	75	1.000	Inparanoid score	I5261
OMA	1	1.010	-	-		QHG47496
OrthoDB	1	1.010	-	-		D1122531at2759
OrthoFinder	1	1.000	-	-		FOG0000998
OrthoInspector	1	1.000	-	-		otm24223
orthoMCL	1	0.900	-	-		OOG6_112342
Panther	1	1.100	-	-	LDO	PTHR11844
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X655
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980