DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syn and SYN2

DIOPT Version :9

Sequence 1:	NP_731459.2	Gene:	Syn / 41247	FlyBaseID:	FBgn0004575	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_598328.1	Gene:	SYN2 / 6854	HGNCID:	11495	Length:	582	Species:	Homo sapiens

Alignment Length:	630	Identity:	247/630 - (39%)
Similarity:	346/630 - (54%)	Gaps:	96/630 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VNFLKRRFSSGDLSSEVDDVDPNSLPPAARPIQDQPTKPPVAGGPPNMPPPPAPGQPAGAAPELS 78
            :|||:||.|.   ||.:.::....:....||...||        ||  ||||.||..:.:|
Human     2 MNFLRRRLSD---SSFIANLPNGYMTDLQRPEPQQP--------PP--PPPPGPGAASASA---- 49

  Fly    79 LSFGAGKTPATAAPAP---PRGVSAPT-SPAKSRESLLQRVQSLTGAARDQGASILGAAVQSATQ 139
                   .|.||:|.|   |...|||. .||.:.........||:.|.:...||   |.:..|..
Human    50 -------APPTASPGPERRPPPASAPAPQPAPTPSVGSSFFSSLSQAVKQTAAS---AGLVDAPA 104

  Fly   140 RAPAFSKDKYFTLLVLDDQNTDWSKYFRGRRLHGDFDIRVEQAEFRDITVVSSADTGPVVTMAAY 204
            .|||.:: |...|||:|:.:.||:|.|||:::.||:||:||||||.::.:|:.||....|.|...
Human   105 PAPAAAR-KAKVLLVVDEPHADWAKCFRGKKVLGDYDIKVEQAEFSELNLVAHADGTYAVDMQVL 168

  Fly   205 RSGTRVARSFRPDFVLIRQPP--RDGSSDYRSTILGLKYGGVPSINSLHSIYQFQDKPWVFSHLL 267
            |:||:|.||||||||||||..  ...:.|:|..|:|::|.|:||||||.|||.|.||||||:.|:
Human   169 RNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLIIGMQYAGLPSINSLESIYNFCDKPWVFAQLV 233

  Fly   268 QLQRRLGRDGFPLIEQTFFPNPRDLFQFTKFPSVLKAGHCHGGVATARLENQSALQDAAGLVSGA 332
            .:.:.||.:.|||||||::||.:::.....||.|:|.||.|.|:...::||....||.|.:|:
Human   234 AIYKTLGGEKFPLIEQTYYPNHKEMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVA-- 296

  Fly   333 GNDSHCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQITLTEKYKSWVDE 397
              .:..|.|.||:||:|:.:.:|||||||||:||.||:||||||.||||||||.::::||.|||.
Human   297 --LTQTYATAEPFIDSKYDIRVQKIGNNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDT 359

  Fly   398 ISELFGGMEVCGLSVVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGRMQNVCRPSMAQ 462
            .||:|||:::|.:..|..|||::||....|.:..|||:.|.|||:.|.:||..:|..:    :::
Human   360 CSEMFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITELVISKMNQL----LSR 420

  Fly   463 TGPGKLPSRSSVSSRAESPT--DEGVAPTPPLPAGPRPAPMGGP-------PP---IPERTSPAV 515
            | |...|.|...:.:.:|.|  |...:.|||    .||.|.|||       ||   :|.|..|..
Human   421 T-PALSPQRPLTTQQPQSGTLKDPDSSKTPP----QRPPPQGGPGQPQGMQPPGKVLPPRRLPPG 480

  Fly   516 GSI--GRLSSRSSISEVPEEPSSSGPSTVGGVRRDSQTSQSSTISSSVSRAGQRPPQT------- 571
            .|:  ...||.||.|..|:.|  .||:|.|    |:.:|.||...:....|.  |||.
Human   481 PSLPPSSSSSSSSSSSAPQRP--GGPTTHG----DAPSSSSSLAEAQPPLAA--PPQKPQPHPQL 537

  Fly   572 ------------------QNSVVED--AEDTMKNLRKTFAGIFGD 596
                              ::|..||  ..:|:::|||:||.:|.|
Human   538 NKSQSLTNAFSFSESSFFRSSANEDEAKAETIRSLRKSFASLFSD 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn	NP_731459.2	Synapsin	151..246	CDD:280283	47/96 (49%)
		ATP-grasp_4	248..452	CDD:302634	101/203 (50%)
		GSK-3_bind	427..>543	CDD:283100	44/129 (34%)
SYN2	NP_598328.1	A	1..29		8/29 (28%)
		Synapsin_N	2..30	CDD:313741	9/30 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..84		24/88 (27%)
		B, linker	33..112		32/103 (31%)
		C, actin-binding and synaptic-vesicle binding	113..420		152/314 (48%)
		Synapsin	115..212	CDD:307960	47/96 (49%)
		Synapsin_C	214..416	CDD:308403	102/205 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..545		41/137 (30%)
		G, Pro-rich linker	421..457		13/40 (33%)
		H, Pro/Ser-rich linker	458..533		27/82 (33%)
		E	534..582		10/47 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2472
eggNOG	1	0.900	-	-		E1_KOG3895
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	375	1.000	Inparanoid score	I2108
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001672
OrthoInspector	1	1.000	-	-		otm41936
orthoMCL	1	0.900	-	-		OOG6_104000
Panther	1	1.100	-	-	LDO	PTHR10841
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3309
SonicParanoid	1	1.000	-	-		X1069
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.890