DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syn and syn1

DIOPT Version :9

Sequence 1:	NP_731459.2	Gene:	Syn / 41247	FlyBaseID:	FBgn0004575	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001119909.1	Gene:	syn1 / 570672	ZFINID:	ZDB-GENE-081105-93	Length:	670	Species:	Danio rerio

Alignment Length:	811	Identity:	258/811 - (31%)
Similarity:	365/811 - (45%)	Gaps:	178/811 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VNFLKRRFSSGDLSSEVDDVDPNS-LPPAARPIQDQPTKPPVAGGPPNMPPPPAPGQPAGAAPEL 77
            :|:|:||.|..:..|.:    ||. :....||...|.:..||..........|||.|..||....
Zfish     1 MNYLRRRLSDSNFMSNL----PNGYMGDLQRPDPPQQSPAPVLSPGSQERRQPAPSQSTGAGFFS 61

  Fly    78 SLSFGAGKTPATAAPAPPRGVSAPTSPAKSRESLLQRVQSLTGAARDQGASILGAAVQSATQRAP 142
            |:|....:|.|.||                                        |....||:|..
Zfish    62 SISNAVKQTTAAAA----------------------------------------ATFNEATERGI 86

  Fly   143 AFSKDKYFTLLVLDDQNTDWSKYFRGRRLHGDFDIRVEQAEFRDITVVSSADTGPVVTMAAYRSG 207
            .....|  .|||:|||.|||:|.|:|:::|||.||:||||:|.::.:|:.|.....|.:.|.|||
Zfish    87 GSGNAK--ILLVIDDQQTDWAKVFKGKKVHGDCDIKVEQADFSEVNLVAHATGSYSVDIEAIRSG 149

  Fly   208 TRVARSFRPDFVLIRQ----PPRDGSSDYRSTILGLKYGGVPSINSLHSIYQFQDKPWVFSHLLQ 268
            .::.:..:|||||:||    ..::|  |:|:.::||:|.|:||:|||||:|.|.|||||||.|.:
Zfish   150 NKITKCIKPDFVLVRQHAFSMAKNG--DHRNIVIGLQYAGLPSVNSLHSVYNFCDKPWVFSQLSR 212

  Fly   269 LQRRLGRDGFPLIEQTFFPNPRDLFQFTKFPSVLKAGHCHGGVATARLENQSALQDAAGLVSGAG 333
            |.::||.:.||||:|.::||.:::.....||.|:|.||.|.|:...:::||...||.|.:|:
Zfish   213 LYKQLGPEEFPLIDQVYYPNHKEMITTPGFPVVVKMGHAHSGMGKVKVDNQYDFQDIASVVA--- 274

  Fly   334 NDSHCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQITLTEKYKSWVDEI 398
             .:..|.|.||:||||:.:.|||||.||||:||.||:||||||.|||||||:.::::|:.|||..
Zfish   275 -LTKTYATSEPFIDAKYDIRIQKIGENYKAYMRTSISGNWKTNTGSAMLEQVAMSDRYRMWVDVC 338

  Fly   399 SELFGGMEVCGLSVVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGRM-QNVCRPSMAQ 462
            ||:|||:::|.:..:..||||:|||.....:..||||.|:|||..:||||..:| :.|.|.|...
Zfish   339 SEVFGGLDICAVEALHGKDGRDYIIEVVGCSMPLIGDQQDEDRALMADLVVAKMNETVPRTSAPT 403

  Fly   463 T----GPGKLP---SRSSVSSRAESPTDEG---------VAPTPPLPAGPRPAPMGGPPPIPERT 511
            |    ||...|   |:|.|....:.|..:|         .|.....|...||:|.|.||
Zfish   404 TVRSQGPAVSPQPISQSRVPQAQQRPPPQGGPQQAAASTAATRQGAPPQQRPSPQGQPP------ 462

  Fly   512 SPAVGSIGRLSSRSSISEVPEEPSSSGPSTVGGVRRDSQTSQSSTISSSVSRAGQRPPQTQNSVV 576
                     ..|:|..|.:.:.|.:..|       |.:|..|..  :|..|.|.||||..|
Zfish   463 ---------AQSQSVTSPIAQNPPAQQP-------RPNQPPQRQ--ASQGSAAPQRPPAAQ---- 505

  Fly   577 EDAEDTMKNLRKTFAGIFGDMXEIANKKRGRTASETSSGSGPGSVPSSAGPGSGFSSSFLGKQFS 641
                                    ...:||...|:...|      |...||.:|      |:...
Zfish   506 ------------------------IPAQRGSPQSQRQGG------PQQGGPQTG------GQSPK 534

  Fly   642 FAGKGEGVISTQPTQRPSEEPPAIPTTASSAVRPESSVSV------SDSRNTDTLTERAGA---- 696
            .||        ||.|||.:.....||...:...|:.:...      ...|...|...|..|
Zfish   535 PAG--------QPQQRPQQPRQGQPTRQPTQGGPQQTQDAPQPAPQGSPRPPTTQQPRPTAPGQG 591

  Fly   697 ---GYQPVTNYEQQERVNPFDKEPSKSGSAASIHTSSSSSISSSSISSRINRNGNAIQSPPPPAG 758
               |.:|....:.|....|....|:.|||.   ..:.|.|::            |....|..||.
Zfish   592 GPGGTRPPLQQKPQPPQKPSPDHPALSGSP---QLNKSQSLT------------NTFNIPETPAA 641

  Fly   759 PPPPPPTNVTAVGSNANSSSGYRNSFSSSLS 789
            ....|..:    .:.|.:....|.||:|..|
Zfish   642 QHQSPSQD----EAKAETIRNLRKSFASLFS 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn	NP_731459.2	Synapsin	151..246	CDD:280283	43/98 (44%)
		ATP-grasp_4	248..452	CDD:302634	102/203 (50%)
		GSK-3_bind	427..>543	CDD:283100	38/132 (29%)
syn1	NP_001119909.1	Synapsin_N	1..32	CDD:287542	10/34 (29%)
		Synapsin	93..190	CDD:280283	43/98 (44%)
		ATP-grasp_4	192..394	CDD:302634	103/205 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	224	1.000	Domainoid score	I2486
eggNOG	1	0.900	-	-		E1_KOG3895
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	345	1.000	Inparanoid score	I2300
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001672
OrthoInspector	1	1.000	-	-		otm25168
orthoMCL	1	0.900	-	-		OOG6_104000
Panther	1	1.100	-	-	O	PTHR10841
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3309
SonicParanoid	1	1.000	-	-		X1069
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.850