DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syn and Syn3

DIOPT Version :9

Sequence 1:	NP_731459.2	Gene:	Syn / 41247	FlyBaseID:	FBgn0004575	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_058805.1	Gene:	Syn3 / 29130	RGDID:	3799	Length:	579	Species:	Rattus norvegicus

Alignment Length:	637	Identity:	227/637 - (35%)
Similarity:	328/637 - (51%)	Gaps:	112/637 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VNFLKRRFSSGDLSSEVDDVDPNSLPPAARPIQDQPTKPPVAGGPPNMPPPPAPGQPAGAAPELS 78
            :|||:||.|.   ||.|.::....:|...|| :...:.|   ..|......|.|...:.::|..|
  Rat     1 MNFLRRRLSD---SSFVANLPNGYMPDLQRP-ESSSSSP---ASPATERRHPQPLAASFSSPGSS 58

  Fly    79 LSFGAGKTPATAAPAPPRGVSAPTSPAKSRESLLQRVQSLTGAARDQGASILGAAVQSATQRAPA 143
            | |.:..:.....|..|.|:..|.:|                             |....|| |.
  Rat    59 L-FSSFSSAMKQTPQAPTGLMEPPTP-----------------------------VTPVVQR-PR 92

  Fly   144 FSKDKYFTLLVLDDQNTDWSKYFRGRRLHGDFDIRVEQAEFRDITVVSSADTGPVVTMAAYRSGT 208
            .       |||:||.:|||||||.|::::||.:||||||||.::.:.:....|.:|.|...|:||
  Rat    93 I-------LLVIDDAHTDWSKYFHGKKVNGDIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGT 150

  Fly   209 RVARSFRPDFVLIRQPPRDG--SSDYRSTILGLKYGGVPSINSLHSIYQFQDKPWVFSHLLQLQR 271
            ::.|||:|||:|:||.....  :.||||.::||:|||:|::|||:|:|.|..||||||.|:::..
  Rat   151 KIVRSFKPDFILVRQHAYSMALAEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFH 215

  Fly   272 RLGRDGFPLIEQTFFPNPRDLFQFTKFPSVLKAGHCHGGVATARLENQSALQDAAGLVSGAGNDS 336
            .||.:.|||:|||||||.:.:.....||.|:|.||.|.|:...::|||...||...:|:.|
  Rat   216 SLGPEKFPLVEQTFFPNHKPMLTAPNFPVVIKLGHAHAGMGKIKVENQHDYQDITSVVAMA---- 276

  Fly   337 HCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQITLTEKYKSWVDEISEL 401
            ..|.|.|.:||:|:.:.|||||:||||:||.||:||||.|.|||||||:.:||:|:.|||..||:
  Rat   277 KTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEM 341

  Fly   402 FGGMEVCGLSVVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGRMQNVCRPSMAQTGPG 466
            |||:::|.:..|.:|:||:|||...||:..|||:..|||::.:||||..:|..:..|..:.  |.
  Rat   342 FGGLDICAVKAVHSKNGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVVSKMSQLLVPGASV--PS 404

  Fly   467 KLPSRSSVSSRAESPTDEGVAPTPPLPAGPRPAPMGGP-----PPIPERTSPAVGSIGRLSSRSS 526
            .|......:..|:||....:.|....|. |||.|.|||     |..|...||   |..|||.:
  Rat   405 PLRPWGPQTKSAKSPGQGQLGPLLGQPQ-PRPPPQGGPRQAQSPQPPRSRSP---SQQRLSPQ-- 463

  Fly   527 ISEVPEEPSSSGPS------------TVGGVRRDSQTSQSSTISS---------SVSRAGQRPPQ 570
             .:.|..|.|..|.            ..||...:..:..::::||         |.|:.|:.|.:
  Rat   464 -GQQPVSPQSGSPQQQRSPGSPQLSRASGGSSPNQASKPTASLSSHTRPPVQGRSTSQQGEEPQK 527

  Fly   571 TQN--------------------------SVVEDAEDTMKNLRKTFAGIFGD 596
            |.:                          |..|...:|::||||:||.:|.|
  Rat   528 TASPHPHLNKSQSLTNSLSTSDTSHRGTPSEDEAKAETIRNLRKSFASLFSD 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn	NP_731459.2	Synapsin	151..246	CDD:280283	47/96 (49%)
		ATP-grasp_4	248..452	CDD:302634	102/203 (50%)
		GSK-3_bind	427..>543	CDD:283100	40/132 (30%)
Syn3	NP_058805.1	Synapsin_N	1..29	CDD:402285	12/31 (39%)
		A	1..28		10/29 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..84		16/102 (16%)
		B, linker	28..90		15/95 (16%)
		Synapsin	90..190	CDD:396588	49/107 (46%)
		C, actin-binding and synaptic-vesicle binding	91..398		152/317 (48%)
		Synapsin_C	192..394	CDD:308403	103/205 (50%)
		PRK14971	<380..>530	CDD:237874	42/158 (27%)
		J, Pro-rich linker	399..530		35/139 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..566		37/174 (21%)
		E	531..579		10/47 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2389
eggNOG	1	0.900	-	-		E1_KOG3895
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68320
Inparanoid	1	1.050	381	1.000	Inparanoid score	I1984
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001672
OrthoInspector	1	1.000	-	-		otm46074
orthoMCL	1	0.900	-	-		OOG6_104000
Panther	1	1.100	-	-	O	PTHR10841
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1069
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.820