DRSC/TRiP Functional Genomics Resources

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Protein Alignment Syn and Syn3

DIOPT Version :9

Sequence 1:NP_731459.2 Gene:Syn / 41247 FlyBaseID:FBgn0004575 Length:1041 Species:Drosophila melanogaster
Sequence 2:NP_038750.2 Gene:Syn3 / 27204 MGIID:1351334 Length:579 Species:Mus musculus


Alignment Length:638 Identity:230/638 - (36%)
Similarity:328/638 - (51%) Gaps:114/638 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 VNFLKRRFSSGDLSSEVDDVDPNSLPPAARPIQDQPTKPPVAGGPPNMPPPPAPGQPAGAAPELS 78
            :|||:||.|.   ||.|.::....:|...||  :..:..|.:.......|.|.....:.....|.
Mouse     1 MNFLRRRLSD---SSFVANLPNGYMPDLQRP--ESSSSSPASPATERRHPQPLAASFSSPGSSLF 60

  Fly    79 LSF-GAGKTPATAAPAPPRGVSAPTSPAKSRESLLQRVQSLTGAARDQGASILGAAVQSATQRAP 142
            .|| ||.|    ..|..|.|:..|.:|                             |....|| |
Mouse    61 SSFSGAMK----QTPQAPSGLMEPPTP-----------------------------VTPVVQR-P 91

  Fly   143 AFSKDKYFTLLVLDDQNTDWSKYFRGRRLHGDFDIRVEQAEFRDITVVSSADTGPVVTMAAYRSG 207
            ..       |||:||.:|||||||.|::::||.:||||||||.::.:.:....|.:|.|...|:|
Mouse    92 RI-------LLVIDDAHTDWSKYFHGKKVNGDIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNG 149

  Fly   208 TRVARSFRPDFVLIRQPPRDG--SSDYRSTILGLKYGGVPSINSLHSIYQFQDKPWVFSHLLQLQ 270
            |::.|||:|||:|:||.....  :.||||.::||:|||:|::|||:|:|.|..||||||.|:::.
Mouse   150 TKIVRSFKPDFILVRQHAYSMALAEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIF 214

  Fly   271 RRLGRDGFPLIEQTFFPNPRDLFQFTKFPSVLKAGHCHGGVATARLENQSALQDAAGLVSGAGND 335
            ..||.:.|||:|||||||.:.:.....||.|:|.||.|.|:...::|||...||...:|:.|   
Mouse   215 HSLGPEKFPLVEQTFFPNHKPMLTAPNFPVVIKLGHAHAGMGKIKVENQHDYQDITSVVAMA--- 276

  Fly   336 SHCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQITLTEKYKSWVDEISE 400
             ..|.|.|.:||:|:.:.|||||:||||:||.||:||||.|.|||||||:.:||:|:.|||..||
Mouse   277 -KTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSE 340

  Fly   401 LFGGMEVCGLSVVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGRMQNV---------- 455
            :|||:::|.:..|.:||||:|||...||:..|||:..|||::.:||||..:|..:          
Mouse   341 MFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVVSKMSQLLVPGATVPSP 405

  Fly   456 CRPSMAQTGPGKLPSRSSVSSRAESPTDEGVAPTPPLPAGPRPAPMGGPP----PIPERTSPAVG 516
            .||...||.|.|.|.:..:......|     .|.||...|||.|....||    |..:|.||.  
Mouse   406 LRPWGPQTKPAKSPGQGQLGPLLGQP-----QPRPPPQGGPRQAQSPQPPRSRSPSQQRLSPQ-- 463

  Fly   517 SIGR--LSSRSSISEVPEEPSSSGPSTVGGVRRDSQTSQ-SSTISS---------SVSRAGQRPP 569
              |:  :|.:|...:....|.|...|...|....:|.|: |:::||         |.|:.|:.|.
Mouse   464 --GQQPVSPQSGSPQQQRSPGSPQLSRASGGSSPNQASKPSASLSSHNRPPVQGRSTSQQGEEPQ 526

  Fly   570 QTQN--------------------------SVVEDAEDTMKNLRKTFAGIFGD 596
            ::.:                          |..|...:|::||||:||.:|.|
Mouse   527 KSASPHPHLNKSQSLTNSLSTSDTSHRGTPSEDEAKAETIRNLRKSFASLFSD 579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SynNP_731459.2 Synapsin 151..246 CDD:280283 47/96 (49%)
ATP-grasp_4 248..452 CDD:302634 103/203 (51%)
GSK-3_bind 427..>543 CDD:283100 40/131 (31%)
Syn3NP_038750.2 Synapsin_N 1..29 CDD:371148 12/32 (38%)
A 1..28 10/29 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..83 16/73 (22%)
B, linker 28..90 16/96 (17%)
C, actin-binding and synaptic-vesicle binding 91..398 153/317 (48%)
Synapsin 93..190 CDD:366909 47/103 (46%)
Synapsin_C 192..394 CDD:308403 104/205 (51%)
J, Pro-rich linker 399..530 37/139 (27%)
PAT1 <400..>534 CDD:370676 37/142 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 401..566 39/173 (23%)
E 531..579 10/47 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 229 1.000 Domainoid score I2464
eggNOG 1 0.900 - - E1_KOG3895
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68320
Inparanoid 1 1.050 381 1.000 Inparanoid score I2038
Isobase 1 0.950 - 0 Normalized mean entropy S4740
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001672
OrthoInspector 1 1.000 - - otm43984
orthoMCL 1 0.900 - - OOG6_104000
Panther 1 1.100 - - O PTHR10841
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3309
SonicParanoid 1 1.000 - - X1069
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.800

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