Protein Alignment Syn and Syn1

DIOPT Version :10

• Sequence 1: NP_731459.2
• Gene: Syn / 41247
• FlyBaseID: FBgn0004575
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_062006.1
• Gene: Syn1 / 24949
• RGDID: 3797
• Length: 704
• Species: Rattus norvegicus
• Alignment Length: 840
• Identity: 273/840 - (32%)
• Similarity: 387/840 - (46%)
• Gaps: 216/840 - (25%)

  Fly    14 VNFLKRRFSSGDLSSEVDDVDPNS-LPPAARPIQDQPTKPPVAGGPPNMPPPPAPGQPAGAAPEL 77
            :|:|:||.|..:..:.:    ||. :....||      :||        ||||:...| ||.|
  Rat     1 MNYLRRRLSDSNFMANL----PNGYMTDLQRP------QPP--------PPPPSAASP-GATP-- 44

  Fly    78 SLSFGAGKTPATAAPAPPRGVSAPTSPAKSR-------ESLLQRVQSLTGAA-----RDQGASIL 130
            ..:..:.:..:||||     |::|.:|:...       .||...|:..|.||     ...|....
  Rat    45 GSAAASAERASTAAP-----VASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSG 104

  Fly   131 GAAVQSATQRAPAFSKDKYFTLLVLDDQNTDWSKYFRGRRLHGDFDIRVEQAEFRDITVVSSADT 195
            ||....|..|          .|||:|:.:|||:|||:|:::||:.||:||||||.|:.:|:.|:.
  Rat   105 GAGRGGAAAR----------VLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANG 159

  Fly   196 GPVVTMAAYRSGTRVARSFRPDFVLIRQ----PPRDGSSDYRSTILGLKYGGVPSINSLHSIYQF 256
            |..|.|...|:|.:|.||.:||||||||    ..|:|  ||||.::||:|.|:||:|||||:|.|
  Rat   160 GFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNG--DYRSLVIGLQYAGIPSVNSLHSVYNF 222

  Fly   257 QDKPWVFSHLLQLQRRLGRDGFPLIEQTFFPNPRDLFQFTKFPSVLKAGHCHGGVATARLENQSA 321
            .||||||:.:::|.::||.:.||||:|||:||.:::...|.:|.|:|.||.|.|:...:::||..
  Rat   223 CDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHD 287

  Fly   322 LQDAAGLVSGAGNDSHCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQIT 386
            .||.|.:|:    .:..|.|.||:||||:.|.:||||.||||:||.|::||||||.||||||||.
  Rat   288 FQDIASVVA----LTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIA 348

  Fly   387 LTEKYKSWVDEISELFGGMEVCGLSVVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGR 451
            ::::||.|||..||:|||:::|.:..:..||||::||....|:..||||.|:||::.|.:||..:
  Rat   349 MSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNK 413

  Fly   452 MQNVCRPSMAQTGPGKLPSRSSVSSRAESPTDEGVAP----TPPLPAGP----RPAPMGGPP--- 505
            |.... |......||:       .|.:::|: .|..|    |...||||    ||.|.||||
  Rat   414 MTQAL-PRQRDASPGR-------GSHSQTPS-PGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPG 469

  Fly   506 PIPERTSPAVGSIGRLSSRSSISEVPEEPSSSGPSTVGGVRRDS-----QTSQSSTISSSVSRAG 565
            |.|:|..|               .:.:.|...|...:.|:...:     |...|.|.:...| |.
  Rat   470 PGPQRQGP---------------PLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTAAPQQS-AS 518

  Fly   566 QRPPQTQNSVVEDAEDTMKNLRKTFAGIFGDMXEIANKKRGRTASETSSGSGPGSVPSSAGPGSG 630
            |..|.||                                          |.|..|.|.:.|||:
  Rat   519 QATPMTQ------------------------------------------GQGRQSRPVAGGPGA- 540

  Fly   631 FSSSFLGKQFSFAGKGEGVISTQPTQRPSEEPPAIPTTASSAVRPESSVSVSDSRNTDTLTERAG 695
                                      .|:..|||.|:....|..|:::...|.|.........|.
  Rat   541 --------------------------PPAARPPASPSPQRQAGPPQATRQASISGPAPPKVSGAS 579

  Fly   696 AGYQPVTNYEQQERVNPFDKEPSKSGSAASIHTSSSSSISSSSISSRINRNGNAIQSPPPPAGPP 760
            .|        .|:|..|..|.|   |.|..|..:|.:....        |.|......|.|:||.
  Rat   580 PG--------GQQRQGPPQKPP---GPAGPIRQASQAGPGP--------RTGPPTTQQPRPSGPG 625

  Fly   761 P-----------------PPPTNVTAVG---SNANSSSGYRNSFS--------SSLSKDK 792
            |                 |||....|.|   ...|.|....|:|:        .|||:|:
  Rat   626 PAGRPTKPQLAQKPSQDVPPPIIAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDE 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn	NP_731459.2	Synapsin	150..246	CDD:460438	50/99 (51%)
		CPSase_L_D2	248..452	CDD:473076	101/203 (50%)
		PHA03307	425..>700	CDD:223039	65/290 (22%)
Syn1	NP_062006.1	A	1..28		7/30 (23%)
		Synapsin_N	1..27	CDD:463155	7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..72		21/82 (26%)
		B, linker	29..112		26/98 (27%)
		C, actin-binding and synaptic-vesicle binding	113..420		155/323 (48%)
		Synapsin	115..212	CDD:460438	50/98 (51%)
		CPSase_L_D2	214..416	CDD:473076	102/205 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	418..688		82/381 (22%)
		D, Pro-rich linker	421..655		73/345 (21%)
		PHA03247	<496..683	CDD:223021	54/275 (20%)
		E	656..704		8/30 (27%)