DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syn and Syn1

DIOPT Version :9

Sequence 1:	NP_731459.2	Gene:	Syn / 41247	FlyBaseID:	FBgn0004575	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_062006.1	Gene:	Syn1 / 24949	RGDID:	3797	Length:	704	Species:	Rattus norvegicus

Alignment Length:	840	Identity:	273/840 - (32%)
Similarity:	387/840 - (46%)	Gaps:	216/840 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VNFLKRRFSSGDLSSEVDDVDPNS-LPPAARPIQDQPTKPPVAGGPPNMPPPPAPGQPAGAAPEL 77
            :|:|:||.|..:..:.:    ||. :....||      :||        ||||:...| ||.|
  Rat     1 MNYLRRRLSDSNFMANL----PNGYMTDLQRP------QPP--------PPPPSAASP-GATP-- 44

  Fly    78 SLSFGAGKTPATAAPAPPRGVSAPTSPAKSR-------ESLLQRVQSLTGAA-----RDQGASIL 130
            ..:..:.:..:||||     |::|.:|:...       .||...|:..|.||     ...|....
  Rat    45 GSAAASAERASTAAP-----VASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSG 104

  Fly   131 GAAVQSATQRAPAFSKDKYFTLLVLDDQNTDWSKYFRGRRLHGDFDIRVEQAEFRDITVVSSADT 195
            ||....|..|          .|||:|:.:|||:|||:|:::||:.||:||||||.|:.:|:.|:.
  Rat   105 GAGRGGAAAR----------VLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANG 159

  Fly   196 GPVVTMAAYRSGTRVARSFRPDFVLIRQ----PPRDGSSDYRSTILGLKYGGVPSINSLHSIYQF 256
            |..|.|...|:|.:|.||.:||||||||    ..|:|  ||||.::||:|.|:||:|||||:|.|
  Rat   160 GFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNG--DYRSLVIGLQYAGIPSVNSLHSVYNF 222

  Fly   257 QDKPWVFSHLLQLQRRLGRDGFPLIEQTFFPNPRDLFQFTKFPSVLKAGHCHGGVATARLENQSA 321
            .||||||:.:::|.::||.:.||||:|||:||.:::...|.:|.|:|.||.|.|:...:::||..
  Rat   223 CDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHD 287

  Fly   322 LQDAAGLVSGAGNDSHCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQIT 386
            .||.|.:|:    .:..|.|.||:||||:.|.:||||.||||:||.|::||||||.||||||||.
  Rat   288 FQDIASVVA----LTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIA 348

  Fly   387 LTEKYKSWVDEISELFGGMEVCGLSVVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGR 451
            ::::||.|||..||:|||:::|.:..:..||||::||....|:..||||.|:||::.|.:||..:
  Rat   349 MSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNK 413

  Fly   452 MQNVCRPSMAQTGPGKLPSRSSVSSRAESPTDEGVAP----TPPLPAGP----RPAPMGGPP--- 505
            |.... |......||:       .|.:::|: .|..|    |...||||    ||.|.||||
  Rat   414 MTQAL-PRQRDASPGR-------GSHSQTPS-PGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPG 469

  Fly   506 PIPERTSPAVGSIGRLSSRSSISEVPEEPSSSGPSTVGGVRRDS-----QTSQSSTISSSVSRAG 565
            |.|:|..|               .:.:.|...|...:.|:...:     |...|.|.:...| |.
  Rat   470 PGPQRQGP---------------PLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTAAPQQS-AS 518

  Fly   566 QRPPQTQNSVVEDAEDTMKNLRKTFAGIFGDMXEIANKKRGRTASETSSGSGPGSVPSSAGPGSG 630
            |..|.||                                          |.|..|.|.:.|||:
  Rat   519 QATPMTQ------------------------------------------GQGRQSRPVAGGPGA- 540

  Fly   631 FSSSFLGKQFSFAGKGEGVISTQPTQRPSEEPPAIPTTASSAVRPESSVSVSDSRNTDTLTERAG 695
                                      .|:..|||.|:....|..|:::...|.|.........|.
  Rat   541 --------------------------PPAARPPASPSPQRQAGPPQATRQASISGPAPPKVSGAS 579

  Fly   696 AGYQPVTNYEQQERVNPFDKEPSKSGSAASIHTSSSSSISSSSISSRINRNGNAIQSPPPPAGPP 760
            .|        .|:|..|..|.|   |.|..|..:|.:....        |.|......|.|:||.
  Rat   580 PG--------GQQRQGPPQKPP---GPAGPIRQASQAGPGP--------RTGPPTTQQPRPSGPG 625

  Fly   761 P-----------------PPPTNVTAVG---SNANSSSGYRNSFS--------SSLSKDK 792
            |                 |||....|.|   ...|.|....|:|:        .|||:|:
  Rat   626 PAGRPTKPQLAQKPSQDVPPPIIAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDE 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn	NP_731459.2	Synapsin	151..246	CDD:280283	50/98 (51%)
		ATP-grasp_4	248..452	CDD:302634	101/203 (50%)
		GSK-3_bind	427..>543	CDD:283100	37/126 (29%)
Syn1	NP_062006.1	A	1..28		7/30 (23%)
		Synapsin_N	1..27	CDD:287542	7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..72		21/82 (26%)
		B, linker	29..112		26/98 (27%)
		C, actin-binding and synaptic-vesicle binding	113..420		155/323 (48%)
		Synapsin	115..212	CDD:280283	50/98 (51%)
		ATP-grasp_4	214..416	CDD:302634	102/205 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..688		82/381 (22%)
		D, Pro-rich linker	421..655		73/345 (21%)
		E	656..704		8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2389
eggNOG	1	0.900	-	-		E1_KOG3895
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	381	1.000	Inparanoid score	I1984
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001672
OrthoInspector	1	1.000	-	-		otm46074
orthoMCL	1	0.900	-	-		OOG6_104000
Panther	1	1.100	-	-	O	PTHR10841
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1069
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.820