DRSC/TRiP Functional Genomics Resources

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Protein Alignment Syn and Syn2

DIOPT Version :9

Sequence 1:NP_731459.2 Gene:Syn / 41247 FlyBaseID:FBgn0004575 Length:1041 Species:Drosophila melanogaster
Sequence 2:NP_001104485.1 Gene:Syn2 / 20965 MGIID:103020 Length:586 Species:Mus musculus


Alignment Length:630 Identity:248/630 - (39%)
Similarity:349/630 - (55%) Gaps:92/630 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 VNFLKRRFSSGDLSSEVDDVDPNSLPPAARPIQDQPTKPPVAGGPPNMPPPPAPGQPAGAAPELS 78
            :|||:||.|.   ||.:.::....:....||...||            ||.|.||....:|...:
Mouse     2 MNFLRRRLSD---SSFIANLPNGYMTDLQRPEPQQP------------PPAPGPGAATASAATSA 51

  Fly    79 LSFGAGKTPATA-APAP-PRGVSAPTSPAKSR--ESLLQRVQSLTGAARDQGASILGAAVQSATQ 139
            .|.|..:.|..| |||| |....|||....|.  .||.|.|:. |.|:    |.::.|...||..
Mouse    52 ASPGPERRPPPAQAPAPQPAPQPAPTPSVGSSFFSSLSQAVKQ-TAAS----AGLVDAPAPSAAS 111

  Fly   140 RAPAFSKDKYFTLLVLDDQNTDWSKYFRGRRLHGDFDIRVEQAEFRDITVVSSADTGPVVTMAAY 204
            |       |...|||:|:.:|||:|.|||:::.||:||:||||||.::.:|:.||....|.|...
Mouse   112 R-------KAKVLLVVDEPHTDWAKCFRGKKILGDYDIKVEQAEFSELNLVAHADGTYAVDMQVL 169

  Fly   205 RSGTRVARSFRPDFVLIRQPP--RDGSSDYRSTILGLKYGGVPSINSLHSIYQFQDKPWVFSHLL 267
            |:||:|.||||||||||||..  ...:.|:|..::|::|.|:||||||.|||.|.||||||:.::
Mouse   170 RNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLVIGMQYAGLPSINSLESIYNFCDKPWVFAQMV 234

  Fly   268 QLQRRLGRDGFPLIEQTFFPNPRDLFQFTKFPSVLKAGHCHGGVATARLENQSALQDAAGLVSGA 332
            .:.:.||.:.|||||||::||.|::.....||.|:|.||.|.|:...::||....||.|.:|:  
Mouse   235 AIFKTLGGEKFPLIEQTYYPNHREMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVA-- 297

  Fly   333 GNDSHCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQITLTEKYKSWVDE 397
              .:..|.|.||:||||:.:.:|||||||||:||.||:||||||.||||||||.::::||.|||.
Mouse   298 --LTQTYATAEPFIDAKYDIRVQKIGNNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDA 360

  Fly   398 ISELFGGMEVCGLSVVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGRMQNVCRPSMAQ 462
            .||:|||:::|.:..|..|||::||....|.:..|||:.|.|||:.|.|||..:|..:    :::
Mouse   361 CSEMFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITDLVISKMNQL----LSR 421

  Fly   463 TGPGKLPSRSSVSSRAESPT--DEGVAPTPPLPAGPRPAPMGGP-------PP---IPERTSPAV 515
            | |...|.|...:.:.:|.|  :...:.|||    .||.|.|||       ||   :|.|..|:.
Mouse   422 T-PALSPQRPLTTQQPQSGTLKEPDSSKTPP----QRPPPQGGPGQPQGMQPPGKVLPPRRLPSG 481

  Fly   516 GSI----GRLSSRSSISEVPEEPSSSGPSTVGGVRRDSQTSQSSTISSSVSRA--GQRP---PQT 571
            .|:    ...||.||.|..|:.|  .||:|..|   |:.:|.:|...:...:|  .|:|   ||.
Mouse   482 PSLPSSSSSSSSSSSSSSAPQRP--GGPTTTHG---DASSSSNSLAEAQAPQAAPAQKPQPHPQL 541

  Fly   572 ------------------QNSVVED--AEDTMKNLRKTFAGIFGD 596
                              ::|..||  ..:|:::|||:||.:|.|
Mouse   542 NKSQSLTNAFSFSESSFFRSSANEDEAKAETIRSLRKSFASLFSD 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SynNP_731459.2 Synapsin 151..246 CDD:280283 47/96 (49%)
ATP-grasp_4 248..452 CDD:302634 103/203 (51%)
GSK-3_bind 427..>543 CDD:283100 44/131 (34%)
Syn2NP_001104485.1 A 1..29 8/29 (28%)
Synapsin_N 2..30 CDD:287542 9/30 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..84 23/75 (31%)
B, linker 33..113 32/103 (31%)
C, actin-binding and synaptic-vesicle binding 114..421 154/314 (49%)
Synapsin 116..213 CDD:280283 47/96 (49%)
Synapsin_C 215..417 CDD:280846 104/205 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 421..549 40/137 (29%)
G, Pro-rich linker 422..458 12/40 (30%)
H, Pro/Ser-rich linker 459..537 25/82 (30%)
E 538..586 12/47 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 229 1.000 Domainoid score I2464
eggNOG 1 0.900 - - E1_KOG3895
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 381 1.000 Inparanoid score I2038
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001672
OrthoInspector 1 1.000 - - otm43984
orthoMCL 1 0.900 - - OOG6_104000
Panther 1 1.100 - - LDO PTHR10841
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3309
SonicParanoid 1 1.000 - - X1069
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.850

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