DRSC/TRiP Functional Genomics Resources

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Protein Alignment Syn and Syn1

DIOPT Version :10

Sequence 1:NP_731459.2 Gene:Syn / 41247 FlyBaseID:FBgn0004575 Length:1041 Species:Drosophila melanogaster
Sequence 2:NP_038708.3 Gene:Syn1 / 20964 MGIID:98460 Length:706 Species:Mus musculus


Alignment Length:835 Identity:270/835 - (32%)
Similarity:387/835 - (46%) Gaps:204/835 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 VNFLKRRFSSGDLSSEVDDVDPNS-LPPAARPIQDQPTKPPVAGGPPNMPPPPAPGQPAGAAPEL 77
            :|:|:||.|..:..:.:    ||. :....||      :||        ||||:...| ||.|  
Mouse     1 MNYLRRRLSDSNFMANL----PNGYMTDLQRP------QPP--------PPPPSAASP-GATP-- 44

  Fly    78 SLSFGAGKTPATAAPAPPRGVSAPTSPAKSR-------ESLLQRVQSLTGAA-----RDQGASIL 130
            ..:..:.:..:||||     |::|.:|:...       .||...|:..|.||     ...|....
Mouse    45 GSATASAERASTAAP-----VASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSG 104

  Fly   131 GAAVQSATQRAPAFSKDKYFTLLVLDDQNTDWSKYFRGRRLHGDFDIRVEQAEFRDITVVSSADT 195
            ||....|..|          .|||:|:.:|||:|||:|:::||:.||:||||||.|:.:|:.|:.
Mouse   105 GAGRGGAAAR----------VLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANG 159

  Fly   196 GPVVTMAAYRSGTRVARSFRPDFVLIRQ----PPRDGSSDYRSTILGLKYGGVPSINSLHSIYQF 256
            |..|.|...|:|.:|.||.:||||||||    ..|:|  ||||.::||:|.|:||:|||||:|.|
Mouse   160 GFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNG--DYRSLVIGLQYAGIPSVNSLHSVYNF 222

  Fly   257 QDKPWVFSHLLQLQRRLGRDGFPLIEQTFFPNPRDLFQFTKFPSVLKAGHCHGGVATARLENQSA 321
            .||||||:.:::|.::||.:.||||:|||:||.:::...|.:|.|:|.||.|.|:...:::||..
Mouse   223 CDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHD 287

  Fly   322 LQDAAGLVSGAGNDSHCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQIT 386
            .||.|.:|:    .:..|.|.||:||||:.|.:||||.||||:||.|::||||||.||||||||.
Mouse   288 FQDIASVVA----LTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIA 348

  Fly   387 LTEKYKSWVDEISELFGGMEVCGLSVVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGR 451
            ::::||.|||..||:|||:::|.:..:..||||::||....|:..||||.|:||::.|.:||..:
Mouse   349 MSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNK 413

  Fly   452 M-QNVCRPSMAQTGPGKLPSRSSVSSRAESPTDEGVA---PTPPLPAGP----RPAPMGGPP--- 505
            | |.:.|.......||:       .|.::|.:...:.   .|...||||    ||.|.||||   
Mouse   414 MTQALPRQPQRDASPGR-------GSHSQSSSPGALTLGRQTSQQPAGPPAQQRPPPQGGPPQPG 471

  Fly   506 PIPERTSPAVGSIGRLSSRSSISEVPEEPSSSGPSTVGGVRRDSQTSQSSTISSSVSRAGQRPPQ 570
            |.|:|..|               .:.:.|...|...:.|:.               ..||...||
Mouse   472 PGPQRQGP---------------PLQQRPPPQGQQHLSGLG---------------PPAGSPLPQ 506

  Fly   571 TQNSVVEDAEDTMKNLRKTFAGIFGDMXEIANKKRGRTASETSSGSGPGSVPSSAGPGSGFSSSF 635
            ...|..                       .|.::....|:..:.|.|..|.|.:.|||:      
Mouse   507 RLPSPT-----------------------AAPQQSASQATPVTQGQGRQSRPVAGGPGA------ 542

  Fly   636 LGKQFSFAGKGEGVISTQPTQRPSEEPPAIPTTASSAVRPESSVSVSDSRNTDTLTERAGAGYQP 700
                                 .|:..|||.|:....|..|:::...|.|....|....|..|   
Mouse   543 ---------------------PPAARPPASPSPQRQAGAPQATRQASISGPAPTKASGAPPG--- 583

  Fly   701 VTNYEQQERVNPFDKEPSKSGSAASIHTSSSSSISSSSISSRINRNGNAIQSPPPPAGPPP---- 761
                 .|:|..|..|.|..:|.     |..:|......      |.|......|.|:||.|    
Mouse   584 -----GQQRQGPPQKPPGPAGP-----TRQASQAGPGP------RTGPPTTQQPRPSGPGPAGRP 632

  Fly   762 -------------PPPTNVTAVG---SNANSSSGYRNSFS--------SSLSKDK 792
                         |||....|.|   ...|.|....|:|:        .|||:|:
Mouse   633 AKPQLAQKPSQDVPPPITAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDE 687

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SynNP_731459.2 Synapsin 150..246 CDD:460438 50/99 (51%)
CPSase_L_D2 248..452 CDD:473076 101/203 (50%)
PHA03307 425..>700 CDD:223039 63/285 (22%)
Syn1NP_038708.3 A 1..28 7/30 (23%)
Synapsin_N 1..27 CDD:463155 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 13..72 21/84 (25%)
B, linker 29..112 26/98 (27%)
C, actin-binding and synaptic-vesicle binding 113..420 156/322 (48%)
Synapsin 115..212 CDD:460438 50/98 (51%)
CPSase_L_D2 214..416 CDD:473076 102/205 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..690 78/375 (21%)
D, Pro-rich linker 421..657 69/341 (20%)
PRK07764 <494..687 CDD:236090 54/276 (20%)
E 658..706 8/30 (27%)

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