Protein Alignment Syn and snn-1

DIOPT Version :9

• Sequence 1: NP_731459.2
• Gene: Syn / 41247
• FlyBaseID: FBgn0004575
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_001367952.1
• Gene: snn-1 / 176987
• WormBaseID: WBGene00004913
• Length: 474
• Species: Caenorhabditis elegans
• Alignment Length: 607
• Identity: 166/607 - (27%)
• Similarity: 255/607 - (42%)
• Gaps: 157/607 - (25%)

  Fly    14 VNFLKRRFS-SGDLSSEVDDVDPNSLPPAARPIQDQPTKPPVAGGPPNMPPPPAPGQPAGAAPEL 77
            :||.||:|| |.|....:|||:                     .|||:
 Worm     1 MNFFKRKFSFSEDEGEPMDDVN---------------------SGPPS----------------- 27

  Fly    78 SLSFG--AGKTPATAAPAPPRGVSAPTSPAKSRESLLQRVQSLTGAARDQGASILGAAVQSATQR 140
            |.||.  |.|...|        :|||||||||||||...::......|.:|..::
 Worm    28 SFSFQSIANKVSNT--------ISAPTSPAKSRESLAAALERSLNHDRSRGEPLM---------- 74

  Fly   141 APAFSKDKYFTLLVLDDQNTDWSKYFRGRRLHGDFDIRVEQAEFRDITVVSSADTGPVVTMAAYR 205
                 ||.. .|||:|..:.|||||||.   |.::.|||||.:..::.|:.   |....|:....
 Worm    75 -----KDAK-VLLVIDSHHVDWSKYFRN---HTEYAIRVEQGDIDELDVMC---TEKNCTVELNT 127

  Fly   206 SGTRVARSFRPDFVLIRQPPRDGSSDYRSTIL-----GLKYGGVPSINSLHSIYQFQDKPWVFSH 265
            .|..| |:|.|..|.:      |:...|...|     ......:|.:||..|...|.|:    ::
 Worm   128 PGKDV-RTFTPSAVFL------GAGATRCAQLKTITRAFIAAHIPFLNSHTSAVAFLDR----NN 181

  Fly   266 L-LQLQRRLGRDG--FPLIEQTFFPNPRDLF--QFTKFPSVLKAGHCHGGVATARLENQSALQDA 325
            | .||::....||  .|::....:|:.....  |.:.:|.|:.......|:...::.|...|.|.
 Worm   182 LKKQLKKITLSDGASIPMLPIVHYPHFHKFHQSQSSTYPMVVSVNEGFQGIGKIKVNNHEELCDV 246

  Fly   326 AGL--VSGAGNDSHCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQITLT 388
            .|:  :...|:..   ..::|::|||:.:||||||:.||.|:|:.|..:||:|.||::||||:..
 Worm   247 EGMLQIMSKGDTE---VEVQPFVDAKYDLHIQKIGHEYKTFIRRGICKHWKSNVGSSVLEQISTC 308

  Fly   389 EKYKSWVDEISELFGGMEVCGLSVVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGRMQ 453
            |::|.::..|::..|.|.:|.:.::|:|:|||::....| ..|..|::.|:|||..:.|:
 Worm   309 ERHKKYLKAITDHVGPMHICSIDILVSKEGREFVHDVND-VIAYFGESAEDDRRAASLLL----- 367

  Fly   454 NVCRPSMAQTGPGKLPSRSSVSSRAESPTDEGVAPTPPLPAGPRPAPMGG------PPPIPERTS 512
                             |:.|:.|..||    :|..||..:....|...|      .|.:|.|
 Worm   368 -----------------RALVAPRITSP----IAAEPPATSPTTSAVTNGHGNHGPAPAVPTR-- 409

  Fly   513 PAVGSIGRLSSRSSISEVPEEPSSSGPSTVGGVRRDSQTSQSS---TISSSVSRAGQRPPQTQNS 574
                            .:|..||||..:...|...|...|:..   .....:.|.|.|      .
 Worm   410 ----------------RLPPHPSSSSAAPPRGHMSDKVESRHKDHYDPPPQIPRTGSR------E 452

  Fly   575 VVEDAEDTMKNLRKTFAGIFGD 596
            .|...:|||..|::||||.||:
 Worm   453 SVSYVDDTMGQLKRTFAGFFGE 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn	NP_731459.2	Synapsin	151..246	CDD:280283	29/99 (29%)
		ATP-grasp_4	248..452	CDD:302634	64/210 (30%)
		GSK-3_bind	427..>543	CDD:283100	26/121 (21%)
snn-1	NP_001367952.1	Synapsin	78..>137	CDD:396588	24/66 (36%)
		CPSase_L_D2	168..361	CDD:418439	61/200 (31%)
		PRK14950	<366..>454	CDD:237864	25/137 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I4067
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68320
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001672
OrthoInspector	1	1.000	-	-		oto18829
orthoMCL	1	0.900	-	-		OOG6_104000
Panther	1	1.100	-	-	LDO	PTHR10841
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3309
SonicParanoid	1	1.000	-	-		X1069
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.940