Protein Alignment CG6254 and ZNF335

DIOPT Version :10

• Sequence 1: NP_649983.2
• Gene: CG6254 / 41244
• FlyBaseID: FBgn0037794
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: NP_071378.1
• Gene: ZNF335 / 63925
• HGNCID: 15807
• Length: 1342
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 127/520 - (24%)
• Similarity: 185/520 - (35%)
• Gaps: 127/520 - (24%)

  Fly   200 EEEILEEDVEEDLAEE-EVETVEEEIDTVGEEVEAVEEELETQDATDCLVEEVEHMTEDRYIEES 263
            |||..||:.::|:.:. .::.:||:.|....|.|....:|..|..|.............|.:..
Human   296 EEEGPEEEDDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPR- 359

  Fly   264 QIIEESQVSDFNMETYEIVQHNPQKEPVETKD---------------------TVESIESNEDTQ 307
              :|.|.:.| .:|...:|.....:.|.|.:|                     .||:..|..|.:
Human   360 --LEISDLPD-GVEGEPLVSSQSGQSPPEPQDPEAPSSSGPGHLVAMGKVSRTPVEAGVSQSDAE 421

  Fly   308 EDISREHVTDEEDEISE---------VPAMYKCNICKKPYKKPKAYKRHMEEVHNTVADDLPQLE 363
            .  :.....||.|.:..         :...|:    |..||.||                 |.|.
Human   422 N--AAPSCPDEHDTLPRRRGRPSRRFLGKKYR----KYYYKSPK-----------------PLLR 463

  Fly   364 CNQCKLC---FPTVAQLHAHHRTHVRAKPKTDNC--CPHCEKRFTTSGTLKRHIEGIHNQIKPYV 423
            ...|::|   |.:...|..|..:|....|:...|  |.:..:|::   :||.|:.. |...|||.
Human   464 PFLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWS---SLKEHMFN-HVGSKPYK 524

  Fly   424 CDLCGKSFNYITGLKDHKLVHT-------DECP----FECPVCKRGFKNNARLKIHLDTHSAE-I 476
            ||.|..:..|...:..|..||:       |..|    |.||||.|.:....||..|:.|||.| .
Human   525 CDECSYTSVYRKDVIRHAAVHSRDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKP 589

  Fly   477 YECTVCGLKLKTRRTFNKHKLVHSD---TRQFKCEVCGSAFKRSKTLKAHLILHTGIRPYKCNFC 538
            :.|..||...|.|.||..|.|.|..   .|:||||.|....:..|.|..|.:.|...:|:||:||
Human   590 HMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFC 654

  Fly   539 --------------------GRDFA---------NGSNCRSHKRQAHPKELAE------EEARGV 568
                                .:.||         :..|.|.|.|..|.....|      ||....
Human   655 PYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHASSFEEWGRRHPEEPPSR 719

  Fly   569 TRSTL-LPMLDELTIASKLLKTPAGPCKVKGSRPKAAPKDQD-NGNESPT---KDTDG--AILYE 626
            .|... |..::||   .:......||.......|:..|:... ..:|:|:   .||.|  .|:|:
Human   720 RRPFFSLQQIEEL---KQQHSAAPGPPPSSPGPPEIPPEATTFQSSEAPSLLCSDTLGGATIIYQ 781

  Fly   627  626
            Human   782  781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:462262
		COG5048	<353..554	CDD:227381	71/249 (29%)
		C2H2 Zn finger	364..384	CDD:275368	5/22 (23%)
		C2H2 Zn finger	395..416	CDD:275368	5/20 (25%)
		C2H2 Zn finger	424..444	CDD:275368	5/19 (26%)
		C2H2 Zn finger	452..472	CDD:275368	8/19 (42%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
		C2H2 Zn finger	535..553	CDD:275368	8/46 (17%)
ZNF335	NP_071378.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..102
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..228
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..442		30/151 (20%)
		C2H2 Zn finger	467..487	CDD:275368	5/19 (26%)
		C2H2 Zn finger	497..517	CDD:275368	6/23 (26%)
		zf-H2C2_2	509..534	CDD:463886	10/25 (40%)
		zf-H2C2_5	523..546	CDD:404746	7/22 (32%)
		C2H2 Zn finger	529..545	CDD:275370	2/15 (13%)
		C2H2 Zn finger	564..584	CDD:275368	8/19 (42%)
		zf-H2C2_2	576..601	CDD:463886	10/24 (42%)
		C2H2 Zn finger	592..612	CDD:275368	9/19 (47%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		C2H2 Zn finger	651..672	CDD:275368	3/20 (15%)
		C2H2 Zn finger	680..699	CDD:275368	3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..763		5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1013
		C2H2 Zn finger	1021..1041	CDD:275368
		Involved in the interaction with CCAR2. /evidence=ECO:0000269|PubMed:19131338	1041..1342
		C2H2 Zn finger	1049..1069	CDD:275368
		zf-H2C2_5	1075..1099	CDD:404746
		C2H2 Zn finger	1077..1097	CDD:275368
		zf-H2C2_2	1089..1114	CDD:463886
		C2H2 Zn finger	1105..1126	CDD:275368