DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6254 and ZNF462

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	XP_006717272.1	Gene:	ZNF462 / 58499	HGNCID:	21684	Length:	2567	Species:	Homo sapiens

Alignment Length:	853	Identity:	152/853 - (17%)
Similarity:	242/853 - (28%)	Gaps:	387/853 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CRLCS--------------KEHPTNQNVFFREAKQNSWASTMAMTIGKYF---WVD------IKR 63
            |.|||              |.||   .||  ..||:      |..:|.||   :.|      :..
Human  1769 CSLCSFQSFSKKGIVSHYMKRHP---GVF--PKKQH------ASKLGGYFTAVYADEHEKPTLME 1822

  Fly    64 EDELSN-----------------FLCSECFTLMDCLIEFSERVRKVQILFSKLQLLQSNNLMDY- 110
            |:|..|                 |.|.:||.|.                ||..:||    .|.|
Human  1823 EEERGNFEKAEVEGEAQEIEWLPFRCIKCFKLS----------------FSTAELL----CMHYT 1867

  Fly   111 ----EKIREDCGVATDGWKHIMLGAVDESLPQNDEVFISEEQPIVCQTETSSKMK-SEILMIPNF 170
                ..::.|         .|:||  :....||     |..|...|.::..|..: :..|.|.|.
Human  1868 DHHSRDLKRD---------FIILG--NGPRLQN-----STYQCKHCDSKLQSTAELTSHLNIHNE 1916

  Fly   171 LVEKQCLQEKQDFPKEEDVIEEEMQISGVEEEILEEDVEEDLAEEEVETVEEEIDTVGEEVE--- 232
            ..:|:..:::    :.:.::.::....|...:..:|.....|  |||..::|. ..||.:.:
Human  1917 EFQKRAKRQE----RRKQLLSKQKYADGAFADFKQERPFGHL--EEVPKIKER-KVVGYKCKFCV 1974

  Fly   233 ---------------------------AVEEELE------------TQDATDCLVEEV--EHMTE 256
                                       ||::|.:            .:||:..||..|  ||...
Human  1975 EVHPTLRAICNHLRKHVQYGNVPAVSAAVKQEADDPAHLFLDGLEAAKDASGALVGRVDGEHCLL 2039

  Fly   257 DRYIEE--------------------------------SQIIEESQVS--------------DFN 275
            |..:|:                                :....|.:.|              |.:
Human  2040 DGMLEDETRPGGYHCSQCDRVLMSMQGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRH 2104

  Fly   276 METYEIVQHNPQKEPVETKDTVESIESNEDTQEDISREHVTDEEDEISEVPAMYKCNICKKPYKK 340
            |:|     |:...:|...|........|...:..|.:.|..:.         .|||:.|......
Human  2105 MQT-----HHGHHKPFRCKLCSFKSSYNSRLKTHILKAHAGEH---------AYKCSWCSFSTMT 2155

  Fly   341 PKAYKRHMEEVHNTVADDLPQLECNQCKLCFPTVAQL---HAHH--------------------- 381
            ....|.|..:||.. |..||:          |.:..|   |:||
Human  2156 ISQLKEHSLKVHGK-ALTLPR----------PRIVSLLSSHSHHSSQKATPAEEVEDSNDSSYSE 2209

  Fly   382 -----------------RTHVRAKP------------KTDNCCPHCEKRFTTSG---TLKRHIEG 414
                             |.:.|..|            ||: ...|||....:||   :::||...
Human  2210 PPDVQQQLNHYQSAALARNNSRVSPVPLSGAAAGTEQKTE-AVLHCEFCEFSSGYIQSIRRHYRD 2273

  Fly   415 IHNQIKPYVCDLCGKSFNYITGLKDHKLVHT--------DECP--FECPVCKRGFKNNARLKIHL 469
            .|...|.:.|..|    ::.||.|....:|.        :|.|  ..||:|....|....:..|:
Human  2274 KHGGKKLFKCKDC----SFYTGFKSAFTMHVEAGHSAVPEEGPKDLRCPLCLYHTKYKRNMIDHI 2334

  Fly   470 DTHSAE-------------------IYECTVCGLKLKTRRTFNKHKLVHSDTRQFKCEVCGSAFK 515
            ..|..|                   ::.|..|.....:..:..:|...|::.:.:||::|....|
Human  2335 VLHREERVVPIEVCRSKLSKYLQGVVFRCDKCTFTCSSDESLQQHIEKHNELKPYKCQLCYYETK 2399

  Fly   516 RSKTLKAHL-------------------------------------------------------- 524
            .::.|.:||
Human  2400 HTEELDSHLRDEHKVSRNFELVGRVNLDQLEQMKEKMESSSSDDEDKEEEMNSKAEDRELMRFSD 2464

  Fly   525 ---ILHTGIRPYKCNFCGRDFANGSNCRSH---------------KRQAHPKELAEEEARGVTRS 571
               .|:|..| :.|.||||.|:.||....|               :.:.||||:.|       .|
Human  2465 HGAALNTEKR-FPCEFCGRAFSQGSEWERHVLRHGMALNDTKQVSREEIHPKEIME-------NS 2521

  Fly   572 TLLPMLDE 579
            ..:|.::|
Human  2522 VKMPSIEE 2529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071	26/116 (22%)
		COG5048	<353..554	CDD:227381	60/359 (17%)
		C2H2 Zn finger	364..384	CDD:275368	6/60 (10%)
		C2H2 Zn finger	395..416	CDD:275368	7/23 (30%)
		C2H2 Zn finger	424..444	CDD:275368	5/19 (26%)
		C2H2 Zn finger	452..472	CDD:275368	5/19 (26%)
		C2H2 Zn finger	479..499	CDD:275368	3/19 (16%)
		C2H2 Zn finger	507..527	CDD:275368	6/78 (8%)
		zf-H2C2_2	520..544	CDD:290200	12/82 (15%)
		C2H2 Zn finger	535..553	CDD:275368	9/32 (28%)
ZNF462	XP_006717272.1	C2H2 Zn finger	2054..2074	CDD:275368	0/19 (0%)
		C2H2 Zn finger	2088..2108	CDD:275368	3/24 (13%)
		C2H2 Zn finger	2117..2138	CDD:275368	3/20 (15%)
		zf-H2C2_5	2144..2169	CDD:316431	8/24 (33%)
		C2H2 Zn finger	2146..2167	CDD:275368	4/20 (20%)
		C2H2 Zn finger	2317..2337	CDD:275368	5/19 (26%)
		C2H2 Zn finger	2363..2383	CDD:275368	3/19 (16%)
		C2H2 Zn finger	2391..2412	CDD:275368	6/20 (30%)
		C2H2 Zn finger	2477..2497	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100