DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6254 and zbtb33

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001093478.1	Gene:	zbtb33 / 562507	ZFINID:	ZDB-GENE-070412-3	Length:	624	Species:	Danio rerio

Alignment Length:	628	Identity:	126/628 - (20%)
Similarity:	209/628 - (33%)	Gaps:	208/628 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 NFLCSECFTLMDCLIEFSE--RVR--KVQILFSKLQLLQ----SNNLMDYEKIREDCGVATDGWK 125
            ||:.::.|.::...|..|:  |||  :::.|.:..|:|.    :|..:...:::...|::.||..
Zfish    71 NFIKADIFDMVLNYIYTSQMFRVRSDRLEDLINAGQILGVTFIANLAIPLAQVKGLPGLSKDGDN 135

  Fly   126 HIMLGAVDESLPQNDEVFISEEQPIVCQTETSSKMKSEILMIPNFLVEKQCLQEKQDFPKEEDVI 190
            :|:      |.|:..|.. ....||:  |||.|                              :.
Zfish   136 NIV------SSPEKPEDG-GVNMPII--TETFS------------------------------LS 161

  Fly   191 EEEMQISGVEEEILEEDVEEDLAEEEVETVEEE---IDTVGEEVEAVEEELETQDATDCLVEEVE 252
            .||..::|...|..:.|.::.|...:.|..:.:   |..|.:.:|.. .|.:.|..|:
Zfish   162 AEEFNMTGANTEKEDSDSDDVLFVSKTEAPQAQKTKISDVHKNIEGA-PETKKQKVTN------- 218

  Fly   253 HMTEDRYIEESQIIEESQVSD------FNMETYEIVQHNPQK------EPVET-----------K 294
               |:....:|.|.:|.:.|:      .|::...::..:|:|      .||.|           .
Zfish   219 ---EEGVAPKSSIPQEKKSSERNASLQNNLDPDVVILSSPEKSSSILTSPVGTGSNSNPKPPACP 280

  Fly   295 DTVESIESNEDTQED-----------ISREHVTDEEDEISEVPAMYKCNICKKP--------YKK 340
            |:|.|...|.....|           :..||..|...:|:.......|:....|        .||
Zfish   281 DSVPSDPQNVSLPSDNIEVLGVQKKKVLLEHSPDHPGKITLSDVRSSCSSSNGPTNVIPALSVKK 345

  Fly   341 P----------------KAYKRHMEEVHN--TVADDLPQLECNQCKLCFPTVAQLHAHHRTHVRA 387
            .                |.|....|..::  .|.||..:.....||      :|:...
Zfish   346 TITLDKASEIDSLSPGCKVYANIGENTYDIVPVKDDPGEGAAPGCK------SQIQPD------- 397

  Fly   388 KPKTDNCCPHCEKRFTTSGTLKRHIEGIHNQIKPYVCDLCGKSFNYITGLKDHKLVHTDECPFEC 452
            .|.|.:..|..:|:|..            :|...|...:.||:|                  |.|
Zfish   398 SPNTASLSPKSKKKFKP------------DQEDHYEIIMDGKTF------------------FVC 432

  Fly   453 PVCKRGFKNNARLKIHLDTHSAEIYECTVCGLKLKTRRTFNKHKLVHSDTRQFKCEVCGSAFKRS 517
            .||||.:.....|:.|.:|||.|                           |::.|..|...|..:
Zfish   433 IVCKRPYVCLTSLRRHFNTHSWE---------------------------RKYPCHYCNKVFALA 470

  Fly   518 KTLKAHLILHTGIRPYKCNFCGRDFANGSNCRSHKRQAHPKELAEEEARGVTRSTLLPMLDELTI 582
            :....|.|.|||.|.|:|..|...|.|.....:|.:|||.::.:..:.:..:.:.|..:|
Zfish   471 EYRTKHEISHTGERRYQCLLCNEMFLNYQILSTHCKQAHNQDPSGRKEKDDSANNLYRLL----- 530

  Fly   583 ASKLLKTPAGPCKVKGSRPKAAPKDQDNGNESPTKDTDGAILY 625
                      |||....:|.:...|:..|  ||....||.|.|
Zfish   531 ----------PCKTVQFKPYSFVSDESGG--SPVIGEDGTIQY 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071	9/33 (27%)
		COG5048	<353..554	CDD:227381	44/202 (22%)
		C2H2 Zn finger	364..384	CDD:275368	3/19 (16%)
		C2H2 Zn finger	395..416	CDD:275368	3/20 (15%)
		C2H2 Zn finger	424..444	CDD:275368	3/19 (16%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	479..499	CDD:275368	0/19 (0%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
		zf-H2C2_2	520..544	CDD:290200	10/23 (43%)
		C2H2 Zn finger	535..553	CDD:275368	5/17 (29%)
zbtb33	NP_001093478.1	BTB	23..116	CDD:279045	11/44 (25%)
		BTB	33..116	CDD:197585	11/44 (25%)
		C2H2 Zn finger	432..452	CDD:275368	7/19 (37%)
		zf-H2C2_2	444..468	CDD:290200	9/50 (18%)
		C2H2 Zn finger	460..480	CDD:275368	5/19 (26%)
		C2H2 Zn finger	488..504	CDD:275368	4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000