DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6254 and Sry-delta

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	429	Identity:	99/429 - (23%)
Similarity:	170/429 - (39%)	Gaps:	104/429 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 GAVD------------ESLPQNDEVFISEEQPIVCQTETSSKMKSEILMIPNFLVEKQCLQEKQD 182
            ||||            |:|  :.:|..|::...:..|..::.:::::.:.|...:..:|.||..|
  Fly     8 GAVDLSDTGSSSSMRYETL--SAKVPSSQKTVSLVLTHLANCIQTQLDLKPGARLCPRCFQELSD 70

  Fly   183 F---------------PKEEDVIEEEMQISGVEEEILEEDVEEDLAEEEVET-VEEEIDTVGEEV 231
            :               .:.:..::.|.::....|:||.|:||  :.:.:||| .:.|.|.:..|:
  Fly    71 YDTIMVNLMTTQKRLTTQLKGALKSEFEVPESGEDILVEEVE--IPQSDVETDADAEADALFVEL 133

  Fly   232 EAVEEELETQDATDCLVEEVEHMTEDRYIEESQIIEESQVSDFNMETYEIVQHNPQKEPVETKDT 296
            ...:||.:|:...:.:.||.|...:|   ::..|.|:..|.|              .|.:..|.
  Fly   134 VKDQEESDTEIKREFVDEEEEEDDDD---DDEFICEDVDVGD--------------SEALYGKS- 180

  Fly   297 VESIESNEDTQEDISREHVTDEEDEISEVPAMYKCNICKKPYKKPKAYKRHMEEVHNTVADDLPQ 361
                               :|.||..::.....:|..|.|.|......::|:.|.|:    ..|.
  Fly   181 -------------------SDGEDRPTKKRVKQECTTCGKVYNSWYQLQKHISEEHS----KQPN 222

  Fly   362 LECNQCKLCFPTVAQLHAHHRTHVRAKPKTDNCCPHCEKRFTTSGTLKRHIEGIHNQIKPYVCDL 426
            ..|..|.:.......|..|...|   :.||:..|.:|.|.|:......||:. :|...|.|.|:.
  Fly   223 HICPICGVIRRDEEYLELHMNLH---EGKTEKQCRYCPKSFSRPVNTLRHMR-MHWDKKKYQCEK 283

  Fly   427 CGKSFNYITGLKDHKLVHTDECPFECPVCKRGFKNNARLKIHLDTHSAEIYECTVCGLKLKTRRT 491
            ||..|:....|.:|:|.|..|   |.|:.                       |::|.:..|:|:|
  Fly   284 CGLRFSQDNLLYNHRLRHEAE---ENPII-----------------------CSICNVSFKSRKT 322

  Fly   492 FNKHKLVHSDTR-QFKCEVCGSAFKRSKTLKAHLILHTG 529
            ||.|.|:|.:.| :..|.||..:|....|||.|:..|.|
  Fly   323 FNHHTLIHKENRPRHYCSVCPKSFTERYTLKMHMKTHEG 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071
		COG5048	<353..554	CDD:227381	49/178 (28%)
		C2H2 Zn finger	364..384	CDD:275368	4/19 (21%)
		C2H2 Zn finger	395..416	CDD:275368	6/20 (30%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		C2H2 Zn finger	452..472	CDD:275368	1/19 (5%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
		zf-H2C2_2	520..544	CDD:290200	5/10 (50%)
		C2H2 Zn finger	535..553	CDD:275368
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	50/188 (27%)
		C2H2 Zn finger	225..245	CDD:275368	4/19 (21%)
		C2H2 Zn finger	253..273	CDD:275368	6/20 (30%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..327	CDD:275370	7/16 (44%)
		zf-C2H2	337..359	CDD:278523	8/21 (38%)
		C2H2 Zn finger	339..359	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	59	1.000	Inparanoid score	I2552
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960