DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6254 and CG4936

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	640	Identity:	142/640 - (22%)
Similarity:	228/640 - (35%)	Gaps:	204/640 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDILAE-TQAANRDSTIWHQW--CRLCSKEHPTNQNVFFREAKQNSWASTMAMTIGKYFWVDIK 62
            |.|..|. :.||...||  .:|  ||:|.::........|.:..:..    :...|.:...|.||
  Fly     1 MRDSAAHASPAAAATST--QKWIVCRVCLQQPKEPMASIFNDDSEKD----LTHMIRECGGVPIK 59

  Fly    63 REDELSNFLCSECFTLMDCLIEFSERVRKVQILFSKLQLLQSNNLMDYEKIREDCGVATDGWKHI 127
            :.|...:.:|.:||.::....:|.|..::                 .|..:|:
  Fly    60 QFDHYPDKICEKCFKVLKMAFKFRETCQR-----------------SYGHLRQ------------ 95

  Fly   128 MLGAVDESLPQNDEVFISEEQPIVCQTETSSKMKSEILMIPNFLVEKQCLQEKQDFPKEEDVIEE 192
            .:|.|:          :.:..|....:||::|:                         |.||..:
  Fly    96 FVGPVE----------VEQRPPEKKGSETATKL-------------------------EPDVDPD 125

  Fly   193 EMQISGVEEEILEEDVEEDLAEEEVETVEEEIDTVG----EEVE-AVEEELETQDATDCLVEEVE 252
            |.:   .|.|..|||.:.||.|......::..:|.|    :|:| .:..|||.        :.:.
  Fly   126 EAE---QEPEHDEEDEDVDLDESHYAEADDAAETQGGVFHDEIEDGILVELEK--------DRIV 179

  Fly   253 HMTEDRYIEESQIIEESQVSDFNMETYE---IVQHNPQKE-----------PVETKDTVESIESN 303
            |:..:: :||..||||  |.|. .||||   |.......|           .:|..|.||..:..
  Fly   180 HVKNEQ-VEEDGIIEE--VYDV-YETYEGDLIPDQGYDHEMADQALSELSAEIEYLDQVEHDQLT 240

  Fly   304 EDTQEDISREHVTDEEDEISEVPAMYKCNICKKPYKKPKAYKRHMEEVHNTVADDLPQLECNQCK 368
            |...||.:...:...|:|.  ||:              |:.:
  Fly   241 ESAHEDDAEVDLNSTEEEF--VPS--------------KSVR----------------------- 266

  Fly   369 LCFPTVAQLHAHHRTHVRAKPK------------------TDNCCP-----------------HC 398
                  |.:||.:.|..|..|:                  ||...|                 ..
  Fly   267 ------ASIHARNATKRRVNPRRSATSTASVAVESSTSKTTDRGNPLKVRRGNSDSAGSKMSIKS 325

  Fly   399 EKRFTTSGTLKRHIEGI------------HNQIKPYVCDLCGKSFNYITGLKDHKLVHTDECPFE 451
            ||..:....|.|...||            ..:.| |:||:||..:...:.|.:|..||:...|.|
  Fly   326 EKDISIGEVLARKHSGIKTKGGHKILLGDKKEFK-YICDVCGNMYPSQSRLTEHIKVHSGVKPHE 389

  Fly   452 CPVCKRGFKNNARLKIHLDTHSA-EIYECTVCGLKLKTRRTFNKHKLVHSDTRQFKCEVCGSAFK 515
            |.:|...|....:|..|::||:. ..|:|:.|........|.|||..:|::.|.::|:||...|.
  Fly   390 CEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFT 454

  Fly   516 RSKTLKAHLILHTGIRPYKCNFCGRDFANGSNCRSHKRQAHPK--ELAEEEARGV 568
            .:.|||.|.::|||.:|:.|:.||:.|......|:| |..|.:  :.|.|...|:
  Fly   455 YTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNH-RVIHERRGQSARESVAGL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071	15/79 (19%)
		COG5048	<353..554	CDD:227381	61/248 (25%)
		C2H2 Zn finger	364..384	CDD:275368	3/19 (16%)
		C2H2 Zn finger	395..416	CDD:275368	7/49 (14%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		C2H2 Zn finger	452..472	CDD:275368	5/19 (26%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
		zf-H2C2_2	520..544	CDD:290200	11/23 (48%)
		C2H2 Zn finger	535..553	CDD:275368	6/17 (35%)
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	15/93 (16%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	9/23 (39%)
		COG5048	386..>447	CDD:227381	18/60 (30%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	7/22 (32%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..455	CDD:290200	9/22 (41%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		zf-H2C2_2	459..481	CDD:290200	10/21 (48%)
		C2H2 Zn finger	474..494	CDD:275368	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	59	1.000	Inparanoid score	I2552
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050