DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6254 and prdm9

DIOPT Version :9

Sequence 1:NP_649983.2 Gene:CG6254 / 41244 FlyBaseID:FBgn0037794 Length:634 Species:Drosophila melanogaster
Sequence 2:NP_957196.1 Gene:prdm9 / 393876 ZFINID:ZDB-GENE-040426-1319 Length:853 Species:Danio rerio


Alignment Length:721 Identity:149/721 - (20%)
Similarity:248/721 - (34%) Gaps:207/721 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 WCR--LCSKEHPTNQN---------VFFREAKQNS--------WASTMAMTIGKYFWVDI----- 61
            |.:  :||:.. |.||         :.||..:..|        :|...|..:|. .|..|     
Zfish   154 WMKFVVCSRSE-TEQNLVAFQQNGRILFRCCRPISPGQEFRVWYAEEYAQGLGA-IWDKIWDNKC 216

  Fly    62 -----KREDELSNFLCSECFTLMDCLIEFSERVRKVQ----ILFSKLQLLQSNNLMDYEKIREDC 117
                 ..|....|..|..|......|:.....|::..    ..|::...|:|.......:: |.|
Zfish   217 ISQGSTEEQATQNCPCPFCHYSFPTLVYLHAHVKRTHPNEYAQFTQTHPLESEAHTPITEV-EQC 280

  Fly   118 GVATDGWKHIMLGAVDESLPQNDEVFISEEQPIVCQTETSSKM-KSEILMIPNFLVEK--QCLQE 179
            .||:|.........|.|| || :::.....||| .|||.|.:. .|:|......:.::  .|:..
Zfish   281 LVASDEALSTQTQPVTES-PQ-EQISTQNGQPI-HQTENSDEPDASDIYTAAGEISDEIHACVDC 342

  Fly   180 KQDFPKEEDVIEEEMQISGVEEEILEEDVEEDLAE-----EEVETVEEEIDTVGEEVEAVEEELE 239
            .:.|.:...:...:..|...|:.......::..::     ....|.:|:    .:.:|:.:...:
Zfish   343 GRSFLRSCHLKRHQRTIHSKEKPYCCSQCKKCFSQATGLKRHQHTHQEQ----EKNIESPDRPSD 403

  Fly   240 TQDATDCLVEEV------EHMTEDRYIEESQIIEESQVSDFNMETYEIV---QHNPQKEPVE--T 293
            ....|.|.:..|      :|:....:.|..:::|...::....|.:..|   :.:|..||..  .
Zfish   404 IYPCTKCTLSFVAKINLHQHLKRHHHGEYLRLVESGSLTAETEEDHTEVCFDKQDPNYEPPSRGR 468

  Fly   294 KDTVESIE------------------SNEDTQEDIS-------------------REHV---TDE 318
            |.|..|::                  .|::.:.::.                   :.|.   .|:
Zfish   469 KSTKNSLKGRGCPKKVAVGRPRGRPPKNKNLEVEVQKISPICTNCEQSFSDLETLKTHQCPRRDD 533

  Fly   319 EDEISEVP---AMYKCNICKKPYKKPKAYKRHMEEVHNTVADDLPQLE----CNQCKLCFPTVAQ 376
            |.:..|.|   :.|.|..|.:.:......|.|         :.:.|.|    |..|.|.|..:..
Zfish   534 EGDNVEHPQEASQYICGECIRAFSNLDLLKAH---------ECIQQGEGSYCCPHCDLYFNRMCN 589

  Fly   377 LHAHHRT-HVRAKPKTDNCCPHCEKRFTTSGTLKRH----------------------------- 411
            |..|.|| |.:.||   .||..|.|.||.|..||||                             
Zfish   590 LRRHERTIHSKEKP---YCCTVCLKSFTQSSGLKRHQQSHLRRKSHRQSSALFTAAIFPCAYCPF 651

  Fly   412 -------------------------------------------------IEGIHNQI------KP 421
                                                             |:|..|..      |.
Zfish   652 SFTDERYLYKHIRRHHPEMSLKYLSFQEGGVLSVEKPHSCSQCCKSFSTIKGFKNHSCFKQGEKV 716

  Fly   422 YVCDLCGKSFNYITGLKDHKLVHTDECPFECPVCKRGFKNNARLKIHLDTHSAE-IYECTVCGLK 485
            |:|..|||:|::...||.|:.:||.|.|:.|..|.:.|.::.:|.:||.||:.| .:.|:.||..
Zfish   717 YLCPDCGKAFSWFNSLKQHQRIHTGEKPYTCSQCGKSFVHSGQLNVHLRTHTGEKPFLCSQCGES 781

  Fly   486 LKTRRTFNKHKLVHSDTRQFKCEVCGSAFKRSKTLKAHLILHTGIRPYKCNFCGRDFANGSNCRS 550
            .:......:|:..||..|..:|..||.:|.|.::||||..||.|.:.:.|..||:.|....:...
Zfish   782 FRQSGDLRRHEQKHSGVRPCQCPDCGKSFSRPQSLKAHQQLHVGTKLFPCTQCGKSFTRRYHLTR 846

  Fly   551 HKRQAH 556
            |.::.|
Zfish   847 HHQKMH 852

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG6254NP_649983.2 zf-AD 21..99 CDD:285071 21/110 (19%)
COG5048 <353..554 CDD:227381 74/290 (26%)
C2H2 Zn finger 364..384 CDD:275368 8/20 (40%)
C2H2 Zn finger 395..416 CDD:275368 12/98 (12%)
C2H2 Zn finger 424..444 CDD:275368 8/19 (42%)
C2H2 Zn finger 452..472 CDD:275368 6/19 (32%)
C2H2 Zn finger 479..499 CDD:275368 4/19 (21%)
C2H2 Zn finger 507..527 CDD:275368 9/19 (47%)
zf-H2C2_2 520..544 CDD:290200 11/23 (48%)
C2H2 Zn finger 535..553 CDD:275368 5/17 (29%)
prdm9NP_957196.1 PR-SET_PRDM7_9 79..207 CDD:380970 12/54 (22%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q96EQ9 127..133
S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:Q96EQ9 275..277 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 291..322 12/33 (36%)
COG5048 333..755 CDD:227381 75/437 (17%)
C2H2 Zn finger 339..360 CDD:275368 2/20 (10%)