DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6254 and CG8388

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	604	Identity:	139/604 - (23%)
Similarity:	253/604 - (41%)	Gaps:	95/604 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CRLCSKE-HPTNQNVFFREAKQNSWASTMAMTIGKYFWVDIKREDELSNFLCSECFTLMDCLIEF 85
            |.||::. .....|:.|...:.:|..  :...|.|:||:.|. :.:.:.::|..|:..:
  Fly     3 CFLCTQTVDDAAGNIEFASEEADSLG--LRCIIEKHFWLQIP-DSKRAGYVCGPCWEQL------ 58

  Fly    86 SERVRKVQILFSK--LQLLQSNNLMDYEKIREDCG---VATDGWKHIMLGAVDESL--------- 136
                    :||..  |.:.|::..::...::|...   ||:...:||:....|:|:
  Fly    59 --------LLFHNFYLNVEQAHKALEQTVLKETSPPEVVASALEEHIVKSEHDDSVAAAVKRRRG 115

  Fly   137 -PQNDEVFISEEQPIVCQTETSSKMKSEILMIPNFLVEKQCLQE-KQDFPKEE----DVIEEEMQ 195
             |:.           |.|.:...::||        ::|:..|.| |.:||:.:    ||:|::
  Fly   116 RPRK-----------VAQQDAREELKS--------VLEQINLNEIKIEFPEADLTIADVLEDQ-- 159

  Fly   196 ISGVEEEILEEDVEEDLAEEEVETVEEEIDTVGEEVEAVEE-----ELETQDATDCLVEEVEHMT 255
               .|::.|.:|.......|:.|.:|::..|:..:|.....     :|..:..|.||.:..:...
  Fly   160 ---EEQDFLPDDCISKEGAEDPEVLEKKPPTLKRKVSGRSRGRRRVQLAERPNTSCLPKIQKSQE 221

  Fly   256 EDRYIEESQIIEESQVSDFNMETY-EIVQHNPQKEPVETKDTVESIESNED-TQEDISREHVTDE 318
            .:.||.|...: :..:.:..||.: |::.|..:    |.|....::..|.. .:..:..:|:...
  Fly   222 FNDYIREHYKV-QCHICNLPMEDFSEMLAHVRR----EHKQRGYAMCCNRKFLKRGVLVDHLRRH 281

  Fly   319 EDEISEVPAMYKCNICKKPYKKPKAYKRHMEEVHNTVADDLPQLECNQCKLCFPTVAQLHAHHRT 383
            :|     |..:||:||.:.....::.:.|| .:|. :........|.||...|.:......|..|
  Fly   282 QD-----PETFKCSICGRVMGHRRSLELHM-RMHE-IKSRGRLYRCEQCSKAFYSAVVYERHKLT 339

  Fly   384 HV-RAKPKTDNCCPHCEKRFTTSGTLKRHIEGIHNQIKPYVCDLCGKSFNYITGLKDHKLVHT-- 445
            |: |.:.|..  |.||||.:.:..|:::|::.:|..:...:||:||||......|..|...||
  Fly   340 HIPREQWKVP--CTHCEKTYPSQYTMQQHVKLVHLNLYAKICDVCGKSIRGREALARHMEEHTGG 402

  Fly   446 DECPFECPVCKRGFKNNARLKIHLD-THSAEIYECTVCGLKLKTRRTFNKH----KLVHSDTRQF 505
            .:...:|.:|.........|..|:. .|:||..:...|...||...:...|    |..|:..|..
  Fly   403 PQAAIKCHLCDSMLTTKYGLARHIKMMHTAENLQPMQCEFCLKICPSLQAHQHHIKYTHNTARSH 467

  Fly   506 KCEVCGSAFKRSKTLKAHLILHTGIRPYKCNFCGRDFANGSNCRSHKRQAHPKELAEEEARGVTR 570
            :|.:|..||||...||.|:..|||...|.|..|.:.|.:.:|..:|:::.|.||..|...:.:.|
  Fly   468 QCPMCEKAFKRPNELKEHMTTHTGEVLYTCPHCPQTFNSNANMHAHRKKVHRKEWEENRHKRLNR 532

  Fly   571 STLLPMLDELTIASKLLKT 589
            |    ...:..||..:.||
  Fly   533 S----RKSDTIIAVSVRKT 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071	15/79 (19%)
		COG5048	<353..554	CDD:227381	59/208 (28%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		C2H2 Zn finger	395..416	CDD:275368	7/20 (35%)
		C2H2 Zn finger	424..444	CDD:275368	8/19 (42%)
		C2H2 Zn finger	452..472	CDD:275368	4/20 (20%)
		C2H2 Zn finger	479..499	CDD:275368	5/23 (22%)
		C2H2 Zn finger	507..527	CDD:275368	9/19 (47%)
		zf-H2C2_2	520..544	CDD:290200	10/23 (43%)
		C2H2 Zn finger	535..553	CDD:275368	5/17 (29%)
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	12/72 (17%)
		C2H2 Zn finger	264..281	CDD:275368	2/16 (13%)
		C2H2 Zn finger	289..309	CDD:275368	5/20 (25%)
		C2H2 Zn finger	320..340	CDD:275368	5/19 (26%)
		C2H2 Zn finger	350..369	CDD:275368	7/18 (39%)
		C2H2 Zn finger	440..461	CDD:275368	5/20 (25%)
		C2H2 Zn finger	469..489	CDD:275368	9/19 (47%)
		C2H2 Zn finger	497..515	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940