DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6254 and CG10366

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster

Alignment Length:	640	Identity:	204/640 - (31%)
Similarity:	300/640 - (46%)	Gaps:	128/640 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 STIWHQWCRLCSKEH-PTNQNVFFREAKQNSWAS-TMAMTIGKYFWVDIKREDELSNFLCSECFT 77
            |:.|.||||||:|:. ..|.|||.:.......|| .:|..|||||||:|.|.:||...:||||.:
  Fly    22 SSDWRQWCRLCAKDDVQGNLNVFLKNEDSGEAASMELATAIGKYFWVNITRGEELPETICSECLS 86

  Fly    78 LMDCLIEFSERVRKVQILFSKLQLLQSNNLMDYEKIREDCGVATDGWKHIMLGAVDESLPQNDEV 142
            |:..|:.||||:.:||.|:..||...|....:..::|...|:
  Fly    87 LVTSLVNFSERITRVQKLYCILQSTPSQERPNLHELRSKFGL----------------------- 128

  Fly   143 FISEEQPIVCQTETSSKMKSEILMIPNFLVEKQCLQEKQDFPKEEDVIEEEMQISGVEEEILEED 207
             :.||    .|||.            :::.:|..|.|:.:|..||...|....::
  Fly   129 -LDEE----TQTEV------------HYVDKKPKLDEQLEFLPEESPYELANPLT---------- 166

  Fly   208 VEEDLAEEEVETVEEEIDTVGEEVEAVEEELETQDATDCLVEEVEHMTEDRYIEESQIIEESQVS 272
                 .||:.|:|::|.|...||.:..:.:.|.              .|||.:...
  Fly   167 -----PEEKQESVDQEQDQPTEEPDEQDADYEP--------------NEDRVLMSL--------- 203

  Fly   273 DFNMETYEIVQHNPQKEPVETKDTVESIESNEDTQEDISREHVTDEEDEISEVPAMYKCNICKKP 337
               .:.|.|.:.|         .:..|::.:..:.|. :.|...|.|..       ::||.|.:.
  Fly   204 ---CDVYGIQEDN---------SSAGSLDGSSPSTEK-AGEDAADSEKR-------HQCNECLRS 248

  Fly   338 YKKPKAYKRHMEEVHNTVADDLPQLECNQCKLCFPTVAQLHAHHRTHVRAKPKTDNCCPHCEKRF 402
            |...|..:||:.:.|........||:|..|...|....||..|.:.||....:....|..|:|:|
  Fly   249 YATSKTLQRHLRQDHGQTEPTTEQLQCPDCPKKFRLHYQLERHMKWHVPLPKRKQYACSSCDKKF 313

  Fly   403 TTSGTLKRHIEGIH--NQIKPYVCDLCGKSFNYITGLKDHKLVHTDECPFECPVCKRGFKNNARL 465
            .||.:.::|.:.:|  .:.:|.:|:.||...:.::.||:|.|.|||..||||.|||:.||:..||
  Fly   314 ATSASAQQHEQYMHLDERPRPVICEQCGVGVHSMSALKEHVLKHTDYAPFECEVCKKCFKSANRL 378

  Fly   466 KIHLDTHSAEIYECTVCGLKLKTRRTFNKHKLVHSDTRQFKCEVCGSAFKRSKTLKAHLILHTGI 530
            |.|.:||....|.|..||::|.:|.|.|:|:|||:|..|.||:.||..|||:|.||.|||||||:
  Fly   379 KHHKETHDPHKYICPECGMQLNSRTTLNRHRLVHTDQMQHKCDYCGREFKRAKALKNHLILHTGL 443

  Fly   531 RPYKCNFCGRDFANGSNCRSHKRQAHPKELAEEEARGVTRS--TLLPMLDELTIASK------LL 587
            :||.|:||.|.||||||||:||:::||:|||.:||.|..||  ..:|.|:.|...:|      .:
  Fly   444 KPYSCDFCDRTFANGSNCRTHKKKSHPEELAAQEAAGGGRSHNRNIPKLEALKAFTKNKDNLSPV 508

  Fly   588 KTPAGPCKVKGSRPKAAPKD-----------------QDNGNESPTK-DTDGAIL 624
            .|....|...|.:|:.|.||                 .|.|.|:.|: ||..|.:
  Fly   509 ATKQSGCFAFGKKPRPATKDTPASNPAVIQDAQPEPAPDPGGENATQADTPAAAI 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071	37/79 (47%)
		COG5048	<353..554	CDD:227381	91/202 (45%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..416	CDD:275368	7/20 (35%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		C2H2 Zn finger	452..472	CDD:275368	10/19 (53%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		C2H2 Zn finger	507..527	CDD:275368	12/19 (63%)
		zf-H2C2_2	520..544	CDD:290200	16/23 (70%)
		C2H2 Zn finger	535..553	CDD:275368	13/17 (76%)
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071	37/79 (47%)
		PTZ00423	131..>230	CDD:240413	29/165 (18%)
		COG5048	<222..408	CDD:227381	64/193 (33%)
		C2H2 Zn finger	242..263	CDD:275368	7/20 (35%)
		C2H2 Zn finger	275..295	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..357	CDD:275368	16/50 (32%)
		C2H2 Zn finger	365..385	CDD:275368	10/19 (53%)
		C2H2 Zn finger	392..412	CDD:275368	9/19 (47%)
		zf-C2H2	418..440	CDD:278523	13/21 (62%)
		C2H2 Zn finger	420..440	CDD:275368	12/19 (63%)
		zf-H2C2_2	432..457	CDD:290200	16/24 (67%)
		C2H2 Zn finger	448..466	CDD:275368	13/17 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471720
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BQ1Z
Homologene	1	1.000	-	-		H64540
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009990
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840