DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6254 and CG17568

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_609951.2	Gene:	CG17568 / 35198	FlyBaseID:	FBgn0032763	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	602	Identity:	205/602 - (34%)
Similarity:	306/602 - (50%)	Gaps:	118/602 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DSTIWHQWCRLCSKEHP-TNQNVFFREAKQNSWASTMAMTIGKYFWVDIKREDELSNFLCSECFT 77
            |.:.|..|||||:|:.. .|..|...|..|.:|.:.:.|.|.|||.|.::.|||||:.||:||:|
  Fly     3 DGSHWLNWCRLCAKDDAHGNVKVQMNENSQGNWDNVLIMAIRKYFEVQMQLEDELSSVLCTECYT 67

  Fly    78 LMDCLIEFSERVRKVQILFSKLQLLQS--NNLMDYEKIREDCGVATDGWKHIMLGAVDESLP--- 137
            |:..||:|:|.|.|||.:|..|:..::  :..||...:|:..|:..|.|.||:     :.:|
  Fly    68 LISELIDFAEHVTKVQDIFEVLRRTETDGDQEMDVAALRQQFGLCDDDWTHII-----KPIPALE 127

  Fly   138 -QNDEVFISEEQPIVCQTETSSKMKSEILMIPNFLVEKQCLQEKQDFPKEEDVIEEEMQIS--GV 199
             ::|.|:   ::|            :|:|               :|||..| ...:||:||  ..
  Fly   128 MESDNVY---QKP------------AELL---------------KDFPLAE-TSSQEMEISKRTT 161

  Fly   200 EEEILE--EDVEEDLAEEEVETVEEEIDTVGEEVEAVEEELETQDATDCLVEEVEHMTEDRYIEE 262
            ...:::  ::||.::.::|.      ||.....:|....:|:.:|..|.|.:  |.:::.|.  :
  Fly   162 TTHLIQTKKNVEMEIPKQEF------IDLGPILLEKNTSQLDMEDVLDELPQ--EELSQPRL--D 216

  Fly   263 SQIIEESQVSDFNMETYEIVQHNPQKEPVE-----------TKDTVESIESNEDTQEDISREHVT 316
            |.....|..:|...|..:..:.:....||:           |.:|:||      |.|:.::....
  Fly   217 STTSPASMENDVKSEMLDSCEGDDDFLPVDGQLMDLVAVATTPNTLES------TAEEKAKRGRM 275

  Fly   317 DEEDEISEVPAMYKCNICKKPYKKPKAYKRHMEEVHNTVADDLPQLECNQCKLCFPTVAQLHAHH 381
            |             |..|.|.|:...:|::|:|.            ||                .
  Fly   276 D-------------CEKCGKVYRNRASYEKHLER------------EC----------------R 299

  Fly   382 RTHVRAK-PKTDNCCPHCEKRFTTSGTLKRHIEGIHNQIKPYVCDLCGKSFNYITGLKDHKLVHT 445
            |...|.| .||...|..|.|..:::..||.|.||||..:|||:||.|||....||.|.:||||||
  Fly   300 RIERRVKVDKTTTTCDICNKTLSSATALKLHKEGIHQNVKPYICDSCGKQLKTITALNEHKLVHT 364

  Fly   446 DECPFECPVCKRGFKNNARLKIHLDTHSAEIYECTVCGLKLKTRRTFNKHKLVHSDTRQFKCEVC 510
            :..||||.|||.||||.||||.|...|:...:.|.:||.||:||||:|.||:||::.|:.||:||
  Fly   365 ESRPFECTVCKAGFKNRARLKAHYQIHAEPSFVCNICGKKLQTRRTWNMHKVVHTEERRLKCDVC 429

  Fly   511 GSAFKRSKTLKAHLILHTGIRPYKCNFCGRDFANGSNCRSHKRQAHPKELAEEEARGVTRSTLLP 575
            |:.||||||||.||:.|||:|||.||:||:.||..:||||||.:.||:|:.:|:...:.....:|
  Fly   430 GALFKRSKTLKTHLLSHTGLRPYVCNYCGKSFACNANCRSHKLKKHPQEVQQEDGARLPSRLNVP 494

  Fly   576 MLDELTIASKLLKTPAG 592
            .||||.:.::  |.|.|
  Fly   495 TLDELRVMTQ--KLPKG 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071	37/78 (47%)
		COG5048	<353..554	CDD:227381	99/201 (49%)
		C2H2 Zn finger	364..384	CDD:275368	2/19 (11%)
		C2H2 Zn finger	395..416	CDD:275368	8/20 (40%)
		C2H2 Zn finger	424..444	CDD:275368	11/19 (58%)
		C2H2 Zn finger	452..472	CDD:275368	13/19 (68%)
		C2H2 Zn finger	479..499	CDD:275368	12/19 (63%)
		C2H2 Zn finger	507..527	CDD:275368	14/19 (74%)
		zf-H2C2_2	520..544	CDD:290200	15/23 (65%)
		C2H2 Zn finger	535..553	CDD:275368	11/17 (65%)
CG17568	NP_609951.2	zf-AD	10..87	CDD:214871	36/76 (47%)
		COG5048	<313..471	CDD:227381	90/157 (57%)
		C2H2 Zn finger	314..335	CDD:275368	8/20 (40%)
		C2H2 Zn finger	343..363	CDD:275368	11/19 (58%)
		C2H2 Zn finger	371..391	CDD:275368	13/19 (68%)
		C2H2 Zn finger	398..418	CDD:275368	12/19 (63%)
		C2H2 Zn finger	426..446	CDD:275368	14/19 (74%)
		zf-H2C2_2	439..463	CDD:290200	15/23 (65%)
		C2H2 Zn finger	454..475	CDD:275368	12/20 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471721
Domainoid	1	1.000	57	1.000	Domainoid score	I17993
eggNOG	1	0.900	-	-		E33208_3BQ1Z
Homologene	1	1.000	-	-		H64540
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009990
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.740