DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6254 and Zfp335

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	XP_030107665.1	Gene:	Zfp335 / 329559	MGIID:	2682313	Length:	1338	Species:	Mus musculus

Alignment Length:	589	Identity:	137/589 - (23%)
Similarity:	204/589 - (34%)	Gaps:	156/589 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 PQNDEVFISEEQPIVCQTE---TSSKMKSEILMIPNFLVEKQC-------------LQEKQDFP- 184
            ||.|...::::.|.....|   .|.:...|::::..|.. |.|             ::|:...|
Mouse   212 PQGDPSSVAQQPPAPVTEELDLQSLEAMMEVVVVQQFKC-KMCQYRSSTKATLLRHMRERHFRPA 275

  Fly   185 ----------KEEDVIEEEMQISGVEEEILEEDVEED--LAEEEVETVEEEIDTVGEEVEAVEEE 237
                      |...|.:........||:..||:.|:|  :....::.:||:.|....|.|....:
Mouse   276 ALAAAAAATGKRGRVRKWGTSTKTTEEDRPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQ 340

  Fly   238 LETQDATDCLVEEVEHMTEDRYIEESQIIEESQVSD---FNMETYEIVQHNPQKEPVET------ 293
            |..|..|.............|.:..   :|.|.:.|   ..:.:.:..|..|:.:.:|.
Mouse   341 LRLQRPTPSTPRPRRRPGRPRKLPR---LETSDLHDGVGQPLVSSQSTQSPPELQDLEAPSSSGL 402

  Fly   294 -------KDTVESIESNEDTQEDISREHVTDEEDEISE---------VPAMYKCNICKKPYKKPK 342
                   :..|||..|..|.:.  :.....||.|....         :...|:    |..||.||
Mouse   403 RALGKVGRGLVESGVSQSDAEN--AAPSCQDEADAPPRRRGRPSRRFLGKKYR----KYYYKSPK 461

  Fly   343 AYKRHMEEVHNTVADDLPQLECNQCKLC---FPTVAQLHAHHRTHVRAKPKTDNC--CPHCEKRF 402
                             |.|....|::|   |.:...|..|..:|....|:...|  |.:..:|:
Mouse   462 -----------------PLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYRSRRW 509

  Fly   403 TTSGTLKRHIEGIHNQIKPYVCDLCGKSFNYITGLKDHKLVHT-------DECP----FECPVCK 456
            :   :||.|:.. |...|||.||.|..:..|...:..|..||:       |..|    |.||||.
Mouse   510 S---SLKEHMFN-HVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCG 570

  Fly   457 RGFKNNARLKIHLDTHSAE-IYECTVCGLKLKTRRTFNKHKLVHSD---TRQFKCEVCGSAFKRS 517
            |.:....||..|:.|||.| .:.|..||...|.|.||..|.|.|..   .|:||||.|....:..
Mouse   571 RVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDK 635

  Fly   518 KTLKAHLILHTGIRPYKCNFC--------------------GRDFA---------NGSNCRSHKR 553
            |.|..|.:.|...:|:||:||                    .:.||         :..|.|.|.|
Mouse   636 KALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVR 700

  Fly   554 QAHPKELAE------EEARGVTRSTL-LPMLDELTIASKLLKTPAGPCKVKGSRPKAAPKDQDNG 611
            ..|.....|      ||.....|... |..::||   .:...|..||       |.::|     |
Mouse   701 CRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEEL---KQQHSTAPGP-------PLSSP-----G 750

  Fly   612 NESP 615
            .|:|
Mouse   751 PEAP 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071
		COG5048	<353..554	CDD:227381	71/249 (29%)
		C2H2 Zn finger	364..384	CDD:275368	5/22 (23%)
		C2H2 Zn finger	395..416	CDD:275368	5/20 (25%)
		C2H2 Zn finger	424..444	CDD:275368	5/19 (26%)
		C2H2 Zn finger	452..472	CDD:275368	8/19 (42%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
		zf-H2C2_2	520..544	CDD:290200	10/52 (19%)
		C2H2 Zn finger	535..553	CDD:275368	8/46 (17%)
Zfp335	XP_030107665.1	zf-H2C2_5	248..268	CDD:372805	3/20 (15%)
		C2H2 Zn finger	469..489	CDD:275368	5/19 (26%)
		C2H2 Zn finger	499..519	CDD:275368	6/23 (26%)
		zf-H2C2_2	511..536	CDD:372612	10/25 (40%)
		zf-H2C2_5	525..548	CDD:372805	7/22 (32%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		C2H2 Zn finger	566..586	CDD:275368	8/19 (42%)
		zf-H2C2_2	578..603	CDD:372612	10/24 (42%)
		C2H2 Zn finger	594..614	CDD:275368	9/19 (47%)
		C2H2 Zn finger	625..645	CDD:275368	6/19 (32%)
		C2H2 Zn finger	653..674	CDD:275368	3/20 (15%)
		C2H2 Zn finger	682..701	CDD:275368	3/18 (17%)
		C2H2 Zn finger	1022..1042	CDD:275368
		SFP1	<1027..1127	CDD:227516
		C2H2 Zn finger	1050..1070	CDD:275368
		zf-H2C2_5	1076..1100	CDD:372805
		C2H2 Zn finger	1078..1098	CDD:275368
		zf-H2C2_2	1090..1115	CDD:372612
		C2H2 Zn finger	1106..1127	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834455
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030