DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6254 and Zfp407

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	XP_008770443.2	Gene:	Zfp407 / 307213	RGDID:	1310645	Length:	2255	Species:	Rattus norvegicus

Alignment Length:	802	Identity:	185/802 - (23%)
Similarity:	279/802 - (34%)	Gaps:	259/802 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 HQWCRLCSKEHPTNQNVFFREAKQNSWASTMAMTIGKYFWVDIKREDELSNFL--CSECFTLMDC 81
            ||........||.:.::.:.....:     |:..:.....|.:..|.| |||.  .|.|.||...
  Rat  1103 HQSSGTLQSRHPADCSILYDNTNLD-----MSKVLCAPDSVAVVAEQE-SNFNEDHSFCETLHQP 1161

  Fly    82 LI-EFSERVRKVQIL-----FSKLQLLQSNNL----MDYEKIR----------------EDCGVA 120
            |. :.|.:.|::..|     .|....|||.||    :|.|..:                ||.|.:
  Rat  1162 LAKDRSIKPREIVSLNTPSNRSSPGCLQSGNLASSAVDSETAKRNHNLLDDVGDTSAHCEDEGGS 1226

  Fly   121 TDGWKHIMLGAVDESLPQND-------------EVFISEEQ---------PIVCQTETSSKMKSE 163
            .||.:..:|   |:|....|             .|.|..||         .:.|: :||..:|.
  Rat  1227 LDGSEEKVL---DKSPCPGDLDGGHSAESISPVVVKIPREQLDLDGGGQSKVGCE-QTSEDLKD- 1286

  Fly   164 ILMIPNFLVEKQCLQEKQDFPKEEDVIEEEMQISGVEEEILEED-------VEEDLAEEEVETVE 221
             :...:.|..|:.|...|..|                |.|||||       .|.:.|.|.:.:::
  Rat  1287 -VQANSNLESKEILMNSQHEP----------------EVILEEDAPASIGTAENNDAYETIISID 1334

  Fly   222 EEIDTV-----------------GEEVEAVEE----------ELETQDATDCLVEEVEHMTEDRY 259
            ::..|:                 ||.||..||          ||..:|....|        :.:.
  Rat  1335 DKGQTMYSFGRFDSSIIRIKTEDGELVEQPEEGLMVTGGKVSELPLKDCAQGL--------KKKK 1391

  Fly   260 IEESQIIEESQV------------SDFNMETYEIVQHNPQKEPVETKD-----TVESIESNEDTQ 307
            :|.|...|.:::            |..|:       |...|.|.:.|.     ..:|..:..:..
  Rat  1392 VEGSSFGESTRIRCDDCGFLADGLSGLNV-------HIAMKHPTKEKHFHCLLCGKSFYTESNLH 1449

  Fly   308 EDI-SREHVTDEEDEISEVP---AMYKCNICKKPYKKPKAYKRH--------MEEVHNTVADDLP 360
            :.: |..|:.:|:..:.|:|   |.:||..|.:|:...:....|        :.||:..:.:|..
  Rat  1450 QHLASAGHMRNEQASVEELPEGGATFKCVKCTEPFDSEQNLFLHIKGQHEELLREVNKYIVEDTE 1514

  Fly   361 QL-------ECNQCKLC------FPTVAQLHAHHRTHVRAKP-KTDNC----------------- 394
            |:       :.|.||.|      ..::|.| ||.|||..:|| |...|
  Rat  1515 QINREREENQGNVCKYCGKMCRSSNSMAFL-AHIRTHTGSKPFKCKICHFATAQLGDARNHVKRH 1578

  Fly   395 -------CPHCEKRFTTSGTLKRHIEGIHNQIKP----YVCDLCGKSFNYITGLKDHKLVHTDEC 448
                   |..|...|.....|..|:.|.|....|    :.|.||.:||.....|.:|..:||.|.
  Rat  1579 LGMREYKCHVCGVAFVMKKHLNTHLLGKHGVGTPKERKFTCHLCDRSFTEKWALNNHVKLHTGEK 1643

  Fly   449 PFEC--PVCKRGFKNNARLKIHLDTHSAE-IYECTVCGLKLKTRRTFNKHKLVHSDTRQFKCEVC 510
            ||:|  |.|...|...:.:|.|..||:.| .:.|.:||....||....||:..|:..:.|||:.|
  Rat  1644 PFKCTWPTCHYSFLTASAMKDHYRTHTGEKSFLCDLCGFAGGTRHALTKHRRQHTGEKPFKCDEC 1708

  Fly   511 GSAFKRSKTLKAHLILHTGIRPYKCNFCGRDFANGSNC--------------------------- 548
            ..|......|..|..:|||.:||:|.:|  |:.  |||
  Rat  1709 NFASTTQSHLTRHKRVHTGEKPYRCPWC--DYR--SNCAENIRKHILHTGKHEGVKMYNCPKCDY 1769

  Fly   549 --------RSHKRQAHP----KELAEEEARGVTRSTLLPMLDELTIASKLLKTPAGPCKVKGSRP 601
                    |:|.::.||    .:||...|   .:...||. |...|.||..:     |::||...
  Rat  1770 GTNVPVEFRNHLKEQHPDIENPDLAYLHA---GKQAELPS-DVQGIVSKSYE-----CRLKGQGA 1825

  Fly   602 KAAPKDQ-----DNGNESPTKD 618
            .....|.     ....|||.|:
  Rat  1826 TFVETDSPFTAATLAEESPVKE 1847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071	18/85 (21%)
		COG5048	<353..554	CDD:227381	74/280 (26%)
		C2H2 Zn finger	364..384	CDD:275368	9/25 (36%)
		C2H2 Zn finger	395..416	CDD:275368	6/20 (30%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		C2H2 Zn finger	452..472	CDD:275368	6/21 (29%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
		zf-H2C2_2	520..544	CDD:290200	10/23 (43%)
		C2H2 Zn finger	535..553	CDD:275368	8/52 (15%)
Zfp407	XP_008770443.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100