DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6254 and Zfp128

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_722497.1	Gene:	Zfp128 / 243833	MGIID:	2389445	Length:	572	Species:	Mus musculus

Alignment Length:	543	Identity:	132/543 - (24%)
Similarity:	201/543 - (37%)	Gaps:	154/543 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 AVDESLPQNDEVFISEEQPI-------VCQTETSSKMKSEILMIPNFLVEKQCLQEKQDFPKE-- 186
            ||...|.|..|:::::....       :.:.|..:.:|.:.|  |.  :|...:.||..|.|.
Mouse    72 AVISQLEQGAELWVADRGGTGACHPGWILEPEDHTLLKDQGL--PK--MEPSPITEKDGFAKAVP 132

  Fly   187 -EDVIEEEMQISGVEEEILEEDVEEDLAEEEVETVEEEIDTVGEEVEAVEEELETQDATDCLVEE 250
             ..:|..:.:..| :.:.|::|.......:|:....:...::| .|||            |::..
Mouse   133 CRSMIGIDQESDG-QRQALKKDQSNLNDPKEIPLQSQSHKSLG-LVEA------------CVLGL 183

  Fly   251 VEHMTEDRYIEESQIIEESQVSDFNMETYEIVQHNPQ--KEPVETKDTVESIESNEDTQEDISRE 313
            ..::..|....|.....:|||.:        .:|||.  ::..::..| :|.:.| .:|:..
Mouse   184 NTYLLPDISGREYGCTYDSQVKN--------SEHNPSLVRQRTDSPAT-QSFDDN-GSQKAF--- 235

  Fly   314 HVTDEEDEISEVPAMYKCNICKKPYKKPKAYKRHMEEVHNTVADDLPQLECNQCKLCFPTVAQLH 378
                  |:|..:..:.|..:..||||                        |..|...|...|.|.
Mouse   236 ------DQIMPITELTKSQVQDKPYK------------------------CTDCGKSFNHNAHLT 270

  Fly   379 AHHRTHVRAKPKTDNCCPHCEKRFTTSGTLKRHIEGIHNQIKPYVCDLCGKSFNYITGLKDHKLV 443
            .|.|.|...:|   ..|..|.|.|:.:.:|.:| |.||...|||.||.|||||.:.|.|..|:.:
Mouse   271 VHKRIHTGERP---YMCKECGKAFSQNSSLVQH-ERIHTGDKPYKCDECGKSFCHSTHLTVHRRI 331

  Fly   444 HTDECPFECPVCKRGFKNNARLKIHLDTHSAE-IYECTVCGLKLKTRRTFNKHKLVHSDTRQFKC 507
            ||.|.|:||..|.|.|..|:.|..|..||:.| .|.|:|||...........|...|::.|.::|
Mouse   332 HTGEKPYECQDCGRAFNQNSSLGRHKRTHTGEKPYTCSVCGKSFSRTTCLFLHLRTHTEERPYEC 396

  Fly   508 EVCGSAFKRSKTLKAHLILHTGIRPY--------------------------------------- 533
            ..||..|:.|.:|..|...|.|.:||
Mouse   397 NHCGKGFRHSSSLAQHQRKHAGEKPYECRQRLIFEQAPALIKYEWTEPLGCDSPLSQGERTQRSD 461

  Fly   534 ---KCNFCGRDFANGSNCRSHKRQAHPKELAEEEARGVTRSTLLPMLDELTIASKLLKTPAGPCK 595
               |||.||:.|...|:...| :..|.:|  ||..||.:|                  ....||:
Mouse   462 RPFKCNQCGKCFTQSSHLIRH-QLTHSRE--EEPLRGRSR------------------RQEQPCR 505

  Fly   596 VKGSR------------PKAAPK 606
             :|||            |.|.||
Mouse   506 -RGSRLIQNTNSNSRELPVAQPK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071
		COG5048	<353..554	CDD:227381	73/243 (30%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		C2H2 Zn finger	395..416	CDD:275368	7/20 (35%)
		C2H2 Zn finger	424..444	CDD:275368	10/19 (53%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	479..499	CDD:275368	5/19 (26%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
		zf-H2C2_2	520..544	CDD:290200	12/65 (18%)
		C2H2 Zn finger	535..553	CDD:275368	7/17 (41%)
Zfp128	NP_722497.1	KRAB	25..85	CDD:214630	5/12 (42%)
		KRAB	25..64	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..164		4/24 (17%)
		COG5048	<198..401	CDD:227381	73/249 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..231		6/35 (17%)
		zf-C2H2	254..276	CDD:278523	9/45 (20%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..293	CDD:290200	9/27 (33%)
		C2H2 Zn finger	284..304	CDD:275368	7/20 (35%)
		zf-H2C2_2	296..319	CDD:290200	13/23 (57%)
		C2H2 Zn finger	312..332	CDD:275368	10/19 (53%)
		zf-H2C2_2	324..349	CDD:290200	11/24 (46%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		zf-H2C2_2	352..377	CDD:290200	10/24 (42%)
		C2H2 Zn finger	368..388	CDD:275368	5/19 (26%)
		zf-C2H2	394..416	CDD:278523	7/21 (33%)
		C2H2 Zn finger	396..416	CDD:275368	7/19 (37%)
		zf-C2H2	464..486	CDD:278523	8/22 (36%)
		C2H2 Zn finger	466..486	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..529		16/66 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000