DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6254 and Zfp646

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_766337.2	Gene:	Zfp646 / 233905	MGIID:	3665412	Length:	1788	Species:	Mus musculus

Alignment Length:	415	Identity:	99/415 - (23%)
Similarity:	150/415 - (36%)	Gaps:	92/415 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 AEEEVETVEEEIDTVGEEVEAVEEELETQDATDCLVEEVEHMTEDRYIEESQIIEESQVSDFNME 277
            :|||.|...|...|....::..|.||..|     |..|||.:....|         ..:.....:
Mouse   898 SEEEEEGTAETASTHSPPLQLSEAELLNQ-----LQREVEALDGAGY---------GHICGCCGQ 948

  Fly   278 TYEIV-----QHNPQKEPVETKDTVESIESNEDTQE-------------------DISREH---- 314
            ||:.:     .|..|.....|::....:|...|..|                   ||..|.
Mouse   949 TYDDLGSLERHHQSQSSSNRTENVPSHLEGAGDATEMVADHGFEGTVTSVSEEGGDIKSEEGVGG 1013

  Fly   315 -VTDE------EDEISEVPAMYKCNICKKPYKKPKAYKRHMEEVHNTVADDLPQLECNQCKLCFP 372
             |.|.      |..:...|..::||.|.|.|:...:...| .::|.| .|.:    |..|..|:|
Mouse  1014 TVADSLCMQAGESFLESHPRPFQCNQCGKTYRHGGSLVNH-RKIHQT-GDFI----CPVCSRCYP 1072

  Fly   373 TVAQLHAHHRTHVRAKPKTDNCCPHCE-------KRFTTSGTLKRHIEGIHNQIK--PYVCDLCG 428
            .:|....|.|.|.|.|.......|..|       :....:|..:..|..:..::|  | :.:|.|
Mouse  1073 NLAAYRNHLRNHPRCKGSEPQMGPISEAGGCSEPQNAAEAGQEQAVIGQLQEELKVEP-LEELAG 1136

  Fly   429 KSFNYI--TGLKDHKLVH----------TDECPFECPVCKRGFKNNARLKIHLDTHSAEIYECTV 481
            ......  |.:|:.:|..          |.|.||.|.||.|.:|:...|..|..:|....:.|..
Mouse  1137 VKEEVWEGTAVKEEELEQELETGCQTEVTSERPFSCEVCGRTYKHAGSLINHRQSHQTGHFGCQA 1201

  Fly   482 CGLKLKTRRTFNKHKLVHSDTRQFKCEVCGSAFKRSKTLKAHLILHT------GI-------RPY 533
            |........:...|:.:|:|.|||:|..||.||:..|.|..|..:|.      |.       ||:
Mouse  1202 CSKGFSNLMSLKNHRRIHADPRQFRCSECGKAFRLRKQLANHQRVHAERRRSRGTQKLTREDRPF 1266

  Fly   534 KCNFCGRDFANGSNCRSHKRQAHPK 558
            :|..|||.:.:..:..:|  |.:|:
Mouse  1267 RCGQCGRTYRHAGSLMNH--QCNPE 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071
		COG5048	<353..554	CDD:227381	60/234 (26%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		C2H2 Zn finger	395..416	CDD:275368	4/27 (15%)
		C2H2 Zn finger	424..444	CDD:275368	5/21 (24%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	479..499	CDD:275368	3/19 (16%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
		zf-H2C2_2	520..544	CDD:290200	10/36 (28%)
		C2H2 Zn finger	535..553	CDD:275368	5/17 (29%)
Zfp646	NP_766337.2	C2H2 Zn finger	10..31	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..48
		C2H2 Zn finger	69..89	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..196
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	260..280	CDD:275368
		C2H2 Zn finger	288..308	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..360
		C2H2 Zn finger	368..388	CDD:275368
		C2H2 Zn finger	395..415	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..449
		C2H2 Zn finger	459..479	CDD:275368
		C2H2 Zn finger	486..506	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..531
		C2H2 Zn finger	568..588	CDD:275368
		C2H2 Zn finger	608..628	CDD:275368
		C2H2 Zn finger	635..655	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..712
		C2H2 Zn finger	808..828	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	868..886	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..916		6/17 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..976		3/19 (16%)
		C2H2 Zn finger	1037..1057	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1064..1084	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1172..1192	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1199..1219	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1227..1247	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1268..1285	CDD:275368	5/18 (28%)
		C2H2 Zn finger	1295..1315	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1398..1439
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1489
		C2H2 Zn finger	1500..1518	CDD:275368
		C2H2 Zn finger	1526..1544	CDD:275368
		C2H2 Zn finger	1552..1572	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1629
		C2H2 Zn finger	1642..1662	CDD:275368
		C2H2 Zn finger	1669..1689	CDD:275368
		zf-H2C2_2	1681..1706	CDD:372612
		C2H2 Zn finger	1697..1717	CDD:275368
		C2H2 Zn finger	1726..1746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100