Protein Alignment CG6254 and Zfp521

DIOPT Version :10

• Sequence 1: NP_649983.2
• Gene: CG6254 / 41244
• FlyBaseID: FBgn0037794
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: NP_663467.1
• Gene: Zfp521 / 225207
• MGIID: 95459
• Length: 1311
• Species: Mus musculus
• Alignment Length: 630
• Identity: 124/630 - (19%)
• Similarity: 214/630 - (33%)
• Gaps: 190/630 - (30%)

  Fly    72 CSECFTLMDCLIEFSERVRK-----------------VQILFSKLQLLQSNNLMDY-EKI----- 113
            ||:|....|    |.|.::|                 :|.::.....::..:||:: |::
Mouse   248 CSQCEEGFD----FPEDLQKHIAECHPECSPNEDRAALQCMYCHELFVEETSLMNHIEQVHGGEK 308

  Fly   114 REDCGVATDGWKHIMLGAVDESLPQNDEVFISEEQPIVCQ------------------------T 154
            :..|.:.::.:.     .|:|.....|    |.:||..|.                        :
Mouse   309 KNSCSICSESFL-----TVEELYSHMD----SHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLS 364

  Fly   155 ETSSKMKSEILMIPNFLVEKQCLQEKQDF--PKEEDVIEEEMQISGVEEEILEEDVEEDLAEEEV 217
            ..||.|......||.....|:..|:..|.  |..:   :.::..|.:   ...:.:...||..::
Mouse   365 VDSSTMVEAAPPIPKSRGRKRAAQQTSDMTGPSSK---QAKVTYSCI---YCNKQLFSSLAVLQI 423

  Fly   218 ETVEEEIDTVGEEVEAVEEELETQDATDCLVEEVEHMTEDRYIEESQIIEESQ------------ 270
            ......:|. .|:....:..||...:   |....||:.:....::..:|..:.
Mouse   424 HLKTMHLDK-PEQAHICQYCLEVLPS---LYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSE 484

  Fly   271 -VSDFN-METYEIVQH---NPQKEPVETKD--------------TVESIESNEDTQEDISREHVT 316
             |:|.| ::.:....|   ||     ..||              |..|:|           ||:.
Mouse   485 VVNDLNTLQEHIRCSHGFANP-----AAKDSNAFFCPHCYMGFLTDSSLE-----------EHIR 533

  Fly   317 DEEDEIS--------------EVPAMYKCNICKKP--YKKPKAYKRHMEE-----------VHN- 353
            ....::|              .|..:|.|:.|...  :.......:|::|           :||
Mouse   534 QVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNYIHNG 598

  Fly   354 ----------TVADDLPQLE-----------------CNQCKLCFPTVAQLHAHHRTHV-RAKPK 390
                      .||.:...|:                 ||||...:.::.....|.:||: ...||
Mouse   599 KKSRALSPLSPVAIEQTTLKMMQTVGGGPARASGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPK 663

  Fly   391 TDNCCPHCEKRFTTSGTLKRHIEGIHNQIKP--YVCDLCGKSFNYITGLKDHKL-VHTDECPFEC 452
            .  .||.|.|.|....:|.:|:. ||..|..  |:|:.|.|.|..:..|:.|.| :||... |.|
Mouse   664 L--TCPQCNKEFPNQESLLKHVT-IHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVF-FRC 724

  Fly   453 PVCKRGFKNNARLKIHLDT-HSAE--IYECTVCGLKLKTRRTFN---KHKLVHSDTRQFKCEVCG 511
            .:|:..|.:...:::||.. ||.|  :|.||.|....:......   ||..:.:..:..||..||
Mouse   725 TLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCG 789

  Fly   512 SAFKRSKTLKAHLILHTGIRPYKCNFCGRDFANGSNCRSHKRQAH 556
            .:|.....|:.|:..|:  :.|.|.||.:.|........|.|:.|
Mouse   790 ESFGTEVELQCHITTHS--KKYNCRFCSKAFHAVILLEKHLREKH 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:462262	8/43 (19%)
		COG5048	<353..554	CDD:227381	62/238 (26%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		C2H2 Zn finger	395..416	CDD:275368	7/20 (35%)
		C2H2 Zn finger	424..444	CDD:275368	7/20 (35%)
		C2H2 Zn finger	452..472	CDD:275368	5/20 (25%)
		C2H2 Zn finger	479..499	CDD:275368	5/22 (23%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
		C2H2 Zn finger	535..553	CDD:275368	5/17 (29%)
Zfp521	NP_663467.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..108
		COG5048	<83..236	CDD:227381
		C2H2 Zn finger	120..140	CDD:275368
		C2H2 Zn finger	148..168	CDD:275368
		C2H2 Zn finger	176..196	CDD:275368
		C2H2 Zn finger	204..224	CDD:275368
		C2H2 Zn finger	248..265	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..398		9/40 (23%)
		C2H2 Zn finger	407..428	CDD:275368	2/23 (9%)
		C2H2 Zn finger	439..460	CDD:275368	5/23 (22%)
		C2H2 Zn finger	479..498	CDD:275368	3/18 (17%)
		C2H2 Zn finger	636..656	CDD:275368	5/19 (26%)
		C2H2 Zn finger	666..686	CDD:275368	7/20 (35%)
		C2H2 Zn finger	696..713	CDD:275368	5/16 (31%)
		C2H2 Zn finger	724..745	CDD:275368	5/20 (25%)
		C2H2 Zn finger	754..774	CDD:275368	4/19 (21%)
		COG5236	785..>964	CDD:227561	15/50 (30%)
		C2H2 Zn finger	785..805	CDD:275368	6/19 (32%)
		C2H2 Zn finger	811..829	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..883
		C2H2 Zn finger	888..909	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	961..981	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1105..1136
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1258..1279	CDD:275368
		C2H2 Zn finger	1288..1307	CDD:275368