DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6254 and tra-4

DIOPT Version :9

Sequence 1:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001370327.1	Gene:	tra-4 / 180575	WormBaseID:	WBGene00018740	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	116/554 - (20%)
Similarity:	202/554 - (36%)	Gaps:	127/554 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 IKREDELSNFLCSECFTLMDCLIEFSERVRKVQILFSKLQLLQSNNLMDYEKIREDCGVATDGWK 125
            ||:||.::....:|..|:                          .||.....|.|......|
Worm     9 IKQEDSITRPRPTEAPTI--------------------------QNLKQEPAIEEGSSSTMD--- 44

  Fly   126 HIMLGAVDESLPQNDEVFISEEQPIVCQTETSSKMKSEILMIPNFLVEKQCLQEKQDFPKEEDVI 190
            ::::..:|.:.......:..:|..:..:|:          :||....||..:.|.:.:..|||..
Worm    45 NMLMLTIDTNQANWQGTYDDDEMDLNNKTD----------LIPLLETEKTTINEDELYDDEEDDD 99

  Fly   191 EEEMQISGVEEEILEE----DVEEDLAEEEVETVEEEIDTVGEEVEAVEEELETQDATDCLVEEV 251
            ::|....|:..|:|.:    ..:..:.:||.|....::..|||.::.:..|::.......:::|:
Worm   100 DDEEIKKGIGFELLAQALGMSAKVPVEKEEPEKERAKLSGVGEFMKQIRGEIKPIQKERIVLDEL 164

  Fly   252 EHMTED-RYIEESQIIEESQVSDFNMETYEIVQHNPQKEPVETKDTVESIESNEDTQEDISREHV 315
            .....| ......:|.|..|       |..:..|         :|.::....|..|...|.|:.:
Worm   165 GFRVRDPSKFPPCRIAEVQQ-------TLTLADH---------QDGIDLPPPNAPTDVRIVRKLI 213

  Fly   316 TDEEDEISEVPAMYKCNICKKPYKKPKAYKRHMEEVHNTVADD-------------LPQLECNQC 367
            ..:         |.:|..||..:.:...|:||:.:.|..:.::             |.::|.|:.
Worm   214 RQK---------MVRCKKCKNRFIEKNIYERHLRDKHPDLYEEYIREQEEEVELQRLEEIEANRI 269

  Fly   368 -------------KLCFPT----------------VAQLHAHHRTHVRAKP---KTDNCCPHCEK 400
                         ::..|:                |.:...:.|.....:|   |....||.|:|
Worm   270 EELQTGGFIPPENEISQPSEDPNYIPLPGENNGGLVPRFDYYGRIKQLKRPYKKKVSPQCPFCDK 334

  Fly   401 RFTTSGTLKRHIEGIHNQIKPY-VCDLCGKSFNYITGLKDHKLVHTDECPFEC-PV---CKRGFK 460
            ||....:||:|....|.::..: .|..|.|.......:.:|....|..| ||| |:   |.....
Worm   335 RFRNEFSLKKHFAKKHEEMVEFQQCLKCFKCVENDAEMANHDCELTYVC-FECTPIRNLCTDNRL 398

  Fly   461 NNARLKIHLDTHSAEIYECTVCGLKLKTRRTFNKH-KLVHSDTRQFKCEVCGSAFKRSKTLKAHL 524
            .|.|.|.|...:|.  :.|:.|.:|..|.|...|| |:.|..|:.|:|..|...|.....:..|.
Worm   399 LNHRKKFHRGANSG--FRCSFCNMKFLTPRKLRKHKKMSHVFTKTFQCHFCEEIFISEVAVMTHE 461

  Fly   525 ILHTGIRPYKCNFCGRDF-ANG-SNCRSHKRQAH 556
            .:||||..::|..|  || ||. :....|||..|
Worm   462 RMHTGIIKFECKVC--DFRANRYTAMEEHKRDEH 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071	6/37 (16%)
		COG5048	<353..554	CDD:227381	61/253 (24%)
		C2H2 Zn finger	364..384	CDD:275368	4/48 (8%)
		C2H2 Zn finger	395..416	CDD:275368	9/20 (45%)
		C2H2 Zn finger	424..444	CDD:275368	4/19 (21%)
		C2H2 Zn finger	452..472	CDD:275368	7/23 (30%)
		C2H2 Zn finger	479..499	CDD:275368	8/20 (40%)
		C2H2 Zn finger	507..527	CDD:275368	4/19 (21%)
		zf-H2C2_2	520..544	CDD:290200	9/24 (38%)
		C2H2 Zn finger	535..553	CDD:275368	7/19 (37%)
tra-4	NP_001370327.1	COG5236	<329..>519	CDD:227561	55/170 (32%)
		C2H2 Zn finger	415..436	CDD:275368	8/20 (40%)
		C2H2 Zn finger	444..464	CDD:275368	4/19 (21%)
		C2H2 Zn finger	472..490	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000