Protein Alignment TAF1B and TAF1B

DIOPT Version :10

• Sequence 1: NP_649982.1
• Gene: TAF1B / 41242
• FlyBaseID: FBgn0037792
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: NP_005671.3
• Gene: TAF1B / 9014
• HGNCID: 11533
• Length: 588
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 127/600 - (21%)
• Similarity: 212/600 - (35%)
• Gaps: 196/600 - (32%)

  Fly    16 DVCEGTTFQER-------------EGFYYCVECGTQKDQIRAVDITAEDNFDDTAAGRYTARTIR 67
            |:.|...|:||             ||.|||..|....:  |..::|..|...:|.. :...|.::
Human     2 DLEEAEEFKERCTQCAAVSWGLTDEGKYYCTSCHNVTE--RYQEVTNTDLIPNTQI-KALNRGLK 63

  Fly    68 QKKDTEKEDEDDITSWEFY-----NYVLRGFLQELLNMGAKPELKLMTL-QVWAAYLDSMEVAFS 126
            :|.:|||       .|::|     .|:|....:.|.|:|..||||...| ..|..||...:.|:.
Human    64 KKNNTEK-------GWDWYVCEGFQYILYQQAEALKNLGVGPELKNDVLHNFWKRYLQKSKQAYC 121

  Fly   127 KSNKTGLPKLNVRALPIDARIIYNHKTFKKGKKGKKSTLTGDPNDERAKFRLWNRTKRNLDASGY 191
            |:.                  :|.        .|:|.|:..|                ||..|.:
Human   122 KNP------------------VYT--------TGRKPTVLED----------------NLSHSDW 144

  Fly   192 RSHGG-----------ASESEGEQSLHLQWSMRARKSLKRHMPLKHLDKHSRDSKGSMS----CH 241
            .|...           .|.:|.:..:|          .::..|:         ||.|.|    |.
Human   145 ASEPELLSDVSCPPFLESGAESQSDIH----------TRKPFPV---------SKASQSETSVCS 190

  Fly   242 SLRPRVKQLHNFDRNIYCLNIIKLYVVLGIALNMVEDDIQLSDLLRFIDEEHLTKRCMLNYLPGN 306
            .....|:.....::.|..:.:.:......::|....:.|.|||||||::|:|:.......:.|..
Human   191 GSLDGVEYSQRKEKGIVKMTMPQTLAFCYLSLLWQREAITLSDLLRFVEEDHIPYINAFQHFPEQ 255

  Fly   307 VAAKGK---------------ALLKDMELSKMKDKVTNKLLRVNIACMSRFINLSE--YQKPNLH 354
            :...|:               ...|.:|:....|             :.||.:::|  |..||:
Human   256 MKLYGRDRGIFGIESWPDYEDIYKKTVEVGTFLD-------------LPRFPDITEDCYLHPNI- 306

  Fly   355 SLAERYILELALPPR---LLKYVNSLLDLHPPTFFN-------AMTVHPYPRYEARTMAYILYAM 409
             |..:|::|:.||..   |..:|..:..:....|..       |.||    :|:.:.:|.|:..:
Human   307 -LCMKYLMEVNLPDEMHSLTCHVVKMTGMGEVDFLTFDPIAKMAKTV----KYDVQAVAIIVVVL 366

  Fly   410 KLLFGLDDLKERNISESAAKINEKLLEVGGDEAPLLFVFTEWMEFVEMRKVIVSHYNQSFARRFG 474
            ||||.|||..|.::|..|.|.|||    ...:.| .|.|.:|.:.  |:|..
Human   367 KLLFLLDDSFEWSLSNLAEKHNEK----NKKDKP-WFDFRKWYQI--MKKAF------------- 411

  Fly   475 VSTRTGCQVDDILAKEWKE--------KEQGETFGWMQGSAAMKRQH--ENLTHIIETMLKDHFG 529
                      |...::|:|        .|:...:.::....|.|::.  .||.....|::
Human   412 ----------DEKKQKWEEARAKYLWKSEKPLYYSFVDKPVAYKKREMVVNLQKQFSTLV----- 461

  Fly   530 ESSKESMEKEHIEFQ 544
            ||:..:.:|....||
Human   462 ESTATAGKKSPSSFQ 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TAF1B	NP_649982.1	zf-RRN7	12..40	CDD:463348	11/36 (31%)
TAF1B	NP_005671.3	zf-RRN7	7..39	CDD:463348	12/44 (27%)
		B-reader	40..68		6/27 (22%)
		B-linker	69..73		2/8 (25%)
		N-terminal cyclin fold	74..261		36/202 (18%)
		C-terminal cyclin fold	262..372		28/129 (22%)