Protein Alignment MAN2A1 and LManI

DIOPT Version :9

• Sequence 1: NP_002363.2
• Gene: MAN2A1 / 4124
• HGNCID: 6824
• Length: 1144
• Species: Homo sapiens
• Sequence 2: NP_001260350.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Alignment Length: 1076
• Identity: 286/1076 - (26%)
• Similarity: 464/1076 - (43%)
• Gaps: 232/1076 - (21%)

Human   166 LQVFVVPHSHNDPGWLKTFNDYF---RDK-----TQYIFNNMVLKLKEDSRRKFIWSEISYLSKW 222
            :.|.:|||||:|.|||||.:.|:   ::|     .|||.:.:|.:|.:||.|:||..|..:.:||
  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66

Human   223 WDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIG--VKPRSG 285
            :.......:.|||.|:..|:||...|.|.|.||||.||.:::||...|.::|::..|  .:|..|
  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131

Human   286 WAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMP 350
            |.|||||||..||.:..:...:.....|:.|..||...|...:|..|:.:..|.: ::|...|:
  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLKN-SNIFTGML- 194

Human   351 FYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFR 415
            :..|..|      |..|...:.:..|         :.....:..||.:|....:|..:..||.:|
  Fly   195 YNHYSAP------PGFCFDINCEDAP---------IIDGESYDNNVDARVSEFIDYVKNMSKSYR 244

Human   416 TKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSK--FKVKIQFGTLSDFFDALDKADETQ 478
            :..::.|:||||   :|.:..:.|||..:|..|:|.:..  .:|.:.:.|.|.:...|.:..:|
  Fly   245 STHIMVPMGDDF---QYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQT- 305

Human   479 RDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYK 543
                   :|..:.|||.|:.....||:|||||||..||..|......:..:.|...|
  Fly   306 -------WPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLA-------- 355

Human   544 INKFLSSSLYTA-LTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLI 607
               .||.:.|:. |....:.:|:.|||||:|||.|..|..||...||.:::..|    |||
  Fly   356 ---NLSGTQYSEDLDNLSQAMGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAE----NSA---- 409

Human   608 LKD------KLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSV 666
             :|      .||...:.....|.:.:...:||:  ..|:|        :.:.|||.......|.|
  Fly   410 -RDALRSLTNLTSGEFESCLELNISVCAFTQDT--ANNVI--------VTLVNPLAHSSTQYVRV 463

Human   667 YVSSPTVQVFSASGK-------PVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESA 724
            ...:....|....|:       ||..||.|:....|   :|.:|:.|.|.:..:...:.::|.|.
  Fly   464 PAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPN---DTQHELVFEASVDKIANFLIRVLPSP 525

Human   725 SSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFD-QTGLMKQMMTKEDGKHHE 788
                        ||..||...|.::   .:::.:|:|.|.|.|.|| .||.:|.:  |.:|....
  Fly   526 ------------KNIAEDQVQFPVE---RSQDELTVETSLVKLTFDTTTGGLKTV--KMNGFTEN 573

Human   789 VNVQFSWY-------GTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVT 846
            :...|..|       |.: |...||||:|.|.|:                          .:.|.
  Fly   574 IQQTFGIYKGYRGNNGES-KNRSSGAYVFRPYGD--------------------------IEIVN 611

Human   847 HRVRLYHIQGIEGQSVE------VSNIVDIRKVYNR------------------EIAMKISSDIK 887
            ::|.|....|.:.:.|.      :|.::.|.:..||                  ||..:.||:|.
  Fly   612 NKVELSFYNGTKVKEVHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNIS 676

Human   888 SQNRFYTDLNGYQI-----------QPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLG 941
            |:.:||||.||.:|           .|.|:.:   :..|.||:|....:||.:.|:|||:.::.|
  Fly   677 SKGKFYTDSNGREILERERNQREHFTPDMSEA---ISGNYYPVTGQISLQDDEKRITLLNDRAQG 738

Human   942 VSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFR-----ILLEKRSAVNTEEEKKSVSY 1001
            .:||..|::|:::.|||:.||..|:.:.:.:.:....|..     ::|:   ||:.:..::
  Fly   739 GTSLKDGELELMLHRRLLNDDAFGVGEALNETQYGTGLIARGKIYLILD---AVDGKPNQR---- 796

Human  1002 PSLLSHITSSLMNH--PVIPMANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSN 1064
              ||.|   .|..|  .....:|..:|....:..:|    ..:|..:.|::|..        :|.
  Fly   797 --LLQH---QLDQHFWKFFSKSNGVASVNRNMIPDF----FGIPESVELLSLEP--------YSK 844

Human  1065 EAALI----LHRKGFDCRF-------SSKGTGLFCSTTQGKILVQKLLN-KFIVESL--TPSSLS 1115
            :..||    .:.:|....|       |..|..::.:|..|.:|::.:.. ||..:..  .|||:.
  Fly   845 DQILIRLENFNTEGNVVSFNIYPLFESLDGYQIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVE 909

Human  1116 LMHSP--PGTQNISEINLS-------PMEISTFRIQ 1142
            ..|:|  |.|.| |.:|.|       ||:|.||.||
  Fly   910 YYHAPHNPLTAN-STMNASGFVVTLVPMQIRTFIIQ 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAN2A1	NP_002363.2	PLN02701	128..1144	CDD:178304	286/1076 (27%)
		GH38N_Man2A1	165..508	CDD:212131	107/353 (30%)
		Alpha-mann_mid	503..588	CDD:214875	31/85 (36%)
		Glyco_hydro_38C	754..1139	CDD:285047	109/457 (24%)
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	93/293 (32%)
		Alpha-mann_mid	323..398	CDD:286360	31/85 (36%)
		Glyco_hydro_38C	536..941	CDD:285047	109/464 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810