DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaSnap2 and NAPG

DIOPT Version :9

Sequence 1:	NP_649980.1	Gene:	gammaSnap2 / 41239	FlyBaseID:	FBgn0266721	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	XP_011524056.1	Gene:	NAPG / 8774	HGNCID:	7642	Length:	372	Species:	Homo sapiens

Alignment Length:	295	Identity:	91/295 - (30%)
Similarity:	154/295 - (52%)	Gaps:	36/295 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KKIEEAEALIGQT---------DSAANEYAKAGMYFKAATAYRIAKSFDKRKDCLLKAIDCYENN 62
            ||::...:|  :|         ||||:||.      |||.|::.||.|::.||..|:....:|||
Human    72 KKVKRTNSL--KTGFLKWKPDYDSAASEYG------KAAVAFKNAKQFEQAKDACLREAVAHENN 128

  Fly    63 KSWFHAAKSYEQIILLAKETDKLSEVEDYANRACCLYQQHGSPEAAAAALDKAAKMTESKHPDLA 127
            ::.|||||:|||..::.||..||.|......:|..:|.::|:|:.||.||::|.|:.|:..|:.|
Human   129 RALFHAAKAYEQAGMMLKEMQKLPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENVDPEKA 193

  Fly   128 LGFYKRALAVVLIGDSTHQASEFASKVSRILVRLKKYEEATKALKKEISLNLQTKSYGQVGRLVV 192
            :..|::...|....:...||.|...|.||:|||.::::||..:::||.::..:.::|....:..:
Human   194 VQLYQQTANVFENEERLRQAVELLGKASRLLVRGRRFDEAALSIQKEKNIYKEIENYPTCYKKTI 258

  Fly   193 ALILVQLTLEDYVDAKKTFKKWGNRC-----------DPQEVNTLQNLLKAFDDEDPELATKMLA 246
            |.:||.|...|||.|:        ||           ..::...|:.||:.:|.:|.:..:.:..
Human   259 AQVLVHLHRNDYVAAE--------RCVRESYSIPGFNGSEDCAALEQLLEGYDQQDQDQVSDVCN 315

  Fly   247 SPFIRHMDVEYALLSKDVPLPKGNRQMTKNAVDNA 281
            ||..::||.:||.|...:.:|.|..:....|...|
Human   316 SPLFKYMDNDYAKLGLSLVVPGGGIKKKSPATPQA 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaSnap2	NP_649980.1	SNAP	29..239	CDD:305195	70/220 (32%)
		TPR repeat	29..61	CDD:276937	10/31 (32%)
		TPR repeat	65..102	CDD:276937	15/36 (42%)
		TPR repeat	105..140	CDD:276937	12/34 (35%)
		TPR repeat	144..180	CDD:276937	13/35 (37%)
NAPG	XP_011524056.1	SNAP	71..338	CDD:276937	88/281 (31%)
		TPR repeat	90..127	CDD:276937	16/42 (38%)
		TPR repeat	131..168	CDD:276937	15/36 (42%)
		TPR repeat	171..206	CDD:276937	12/34 (35%)
		TPR repeat	210..246	CDD:276937	13/35 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159301
Domainoid	1	1.000	180	1.000	Domainoid score	I3515
eggNOG	1	0.900	-	-		E1_KOG1585
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2838
Inparanoid	1	1.050	211	1.000	Inparanoid score	I3662
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55184
OrthoDB	1	1.010	-	-		D1540214at2759
OrthoFinder	1	1.000	-	-		FOG0003744
OrthoInspector	1	1.000	-	-		otm40472
orthoMCL	1	0.900	-	-		OOG6_103437
Panther	1	1.100	-	-	O	PTHR13768
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4180
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770