DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaSnap2 and napga

DIOPT Version :9

Sequence 1:	NP_649980.1	Gene:	gammaSnap2 / 41239	FlyBaseID:	FBgn0266721	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_001013498.2	Gene:	napga / 541353	ZFINID:	ZDB-GENE-050320-46	Length:	308	Species:	Danio rerio

Alignment Length:	286	Identity:	96/286 - (33%)
Similarity:	160/286 - (55%)	Gaps:	32/286 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AKKIEEAEALIGQT---------------DSAANEYAKAGMYFKAATAYRIAKSFDKRKDCLLKA 55
            |:||.||...|.:.               ||||:|||      |||.|::.||..::.||..|:.
Zfish     2 AQKISEAHEHIAKAEKYLKTSFMKWKPDYDSAASEYA------KAAVAFKNAKQLEQAKDAYLQE 60

  Fly    56 IDCYENNKSWFHAAKSYEQIILLAKETDKLSEVEDYANRACCLYQQHGSPEAAAAALDKAAKMTE 120
            .:.:.||:|.|||||::||..::.|:..::.|...|..:|..:|.::|:|:.||.|||:|.|:.|
Zfish    61 AEAHANNRSLFHAAKAFEQAGMMLKDLQRMPEAVQYIEKASVMYVENGTPDTAAMALDRAGKLME 125

  Fly   121 SKHPDLALGFYKRALAVVLIGDSTHQASEFASKVSRILVRLKKYEEATKALKKEISLNLQTKSYG 185
            ......|:..|::|.||....:...||:|...|.||:|||.:|::||..:|:||.|:..:.::|.
Zfish   126 PLDLSKAVHLYQQAAAVFENEERLRQAAELIGKASRLLVRQQKFDEAAASLQKEKSMYKEMENYP 190

  Fly   186 QVGRLVVALILVQLTLEDYVDAKKTFKK-------WGNRCDPQEVNTLQNLLKAFDDEDPELATK 243
            ...:..:|.:||||...|||.|:|..::       .|:    ::...|::||:|:|::|.|...:
Zfish   191 TCYKKCIAQVLVQLHRADYVAAQKCVRESYSIPGFSGS----EDCAALEDLLQAYDEQDEEQLLR 251

  Fly   244 MLASPFIRHMDVEYALLSKDVPLPKG 269
            :..||.:.:||.:||.|:..:.:|.|
Zfish   252 VCRSPLVTYMDNDYAKLAISLKVPGG 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaSnap2	NP_649980.1	SNAP	29..239	CDD:305195	73/216 (34%)
		TPR repeat	29..61	CDD:276937	9/31 (29%)
		TPR repeat	65..102	CDD:276937	12/36 (33%)
		TPR repeat	105..140	CDD:276937	14/34 (41%)
		TPR repeat	144..180	CDD:276937	16/35 (46%)
napga	NP_001013498.2	SNAP	7..275	CDD:276937	91/277 (33%)
		TPR repeat	29..66	CDD:276937	16/42 (38%)
		TPR repeat	70..107	CDD:276937	12/36 (33%)
		TPR repeat	110..145	CDD:276937	14/34 (41%)
		TPR repeat	149..185	CDD:276937	16/35 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595432
Domainoid	1	1.000	193	1.000	Domainoid score	I3143
eggNOG	1	0.900	-	-		E1_KOG1585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	224	1.000	Inparanoid score	I3493
OMA	1	1.010	-	-		QHG55184
OrthoDB	1	1.010	-	-		D1540214at2759
OrthoFinder	1	1.000	-	-		FOG0003744
OrthoInspector	1	1.000	-	-		mtm6409
orthoMCL	1	0.900	-	-		OOG6_103437
Panther	1	1.100	-	-	O	PTHR13768
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4180
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770