back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAH7 and CA12

DIOPT Version :9

Sequence 1:	NP_001287267.1	Gene:	CAH7 / 41238	FlyBaseID:	FBgn0037788	Length:	304	Species:	Drosophila melanogaster
Sequence 2:	NP_001209.1	Gene:	CA12 / 771	HGNCID:	1371	Length:	354	Species:	Homo sapiens

Alignment Length:	327	Identity:	97/327 - (29%)
Similarity:	158/327 - (48%)	Gaps:	48/327 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHLIALSLIVCCSVSFSW-----ANEWGY--PDLDNNQDEPFPKWGGLCDSGKKQSPINLHVKGA 58
            :|..|:.|:|......|.     .::|.|  ||.:|:..:.:|..|||.     ||||:|| ...
Human     6 LHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLL-----QSPIDLH-SDI 64

  Fly    59 LKGEFDA----LKFENYD-EHQKNLRMVNNGHSIQLSGFDHELTLSGGALLQDFVVEQIHMHW-- 116
            |  ::||    |:|:.|: ...|...:.|||||::|: ...::.:.|  |...:...|:|:||
Human    65 L--QYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLN-LPSDMHIQG--LQSRYSATQLHLHWGN 124

  Fly   117 -----WSEHTINDIRYPLEVHIVHRNT-IYPNMTMAANFKDGIVVIGVLYHVSNTPNEAIGSIIK 175
                 .||||::...:..|:||||.|: :||:.:.|:|..:|:.|:.||..:.:. |.:...|..
Human   125 PNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSF-NPSYDKIFS 188

  Fly   176 SLGAVKSYDSMNKPVLVADSLAVDDLVPS-VENYFTYAGSLTTPTCAEAVTWIVLTETFPVTLDQ 239
            .|..|| |......|   ....:::|:|. ...|:.|.||||||.|...|.|.|......::.:|
Human   189 HLQHVK-YKGQEAFV---PGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQ 249

  Fly   240 VNEFKEIEY------DEGKQLHNNYRELQSENNRAVVLVEQPEQRSGSAGLTASVSLG-LMTLIL 297
            :...:...|      ...:::.||:|::|..:.|.|.......|...:|||    ||| :::|.|
Human   250 LLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL----SLGIILSLAL 310

  Fly   298 AG 299
            ||
Human   311 AG 312

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.