DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH7 and CA8

DIOPT Version :9

Sequence 1:	NP_001287267.1	Gene:	CAH7 / 41238	FlyBaseID:	FBgn0037788	Length:	304	Species:	Drosophila melanogaster
Sequence 2:	NP_001308766.1	Gene:	CA8 / 767	HGNCID:	1382	Length:	290	Species:	Homo sapiens

Alignment Length:	288	Identity:	81/288 - (28%)
Similarity:	135/288 - (46%)	Gaps:	69/288 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EWGYPDLDNNQDEPFPKWGGLCD--SGKKQSPINLHVKGALKGEFDALKFENYDEHQKNLRM--- 80
            ||||        |...:||.:..  :|:.||||||:.:.|           .||....::|:
Human    28 EWGY--------EEGVEWGLVFPDANGEYQSPINLNSREA-----------RYDPSLLDVRLSPN 73

  Fly    81 ---------VNNGHSIQLSGFDHELTLSGGALLQ--DFVVEQIHMHW------WSEHTINDIRYP 128
                     .|:||:||:. ...:..||||.|.|  :|.:.::..||      .||||:|...:|
Human    74 YVVCRDCEVTNDGHTIQVI-LKSKSVLSGGPLPQGHEFELYEVRFHWGRENQRGSEHTVNFKAFP 137

  Fly   129 LEVHIVHRN-TIYPNMTMAANFKDGIVVIGVLYHV--SNTPNEAIGSIIKSL---GAVKSYDSMN 187
            :|:|::|.| |::.::..|.....||.:|.:...:  .:...:|:..|::.:   |..|:....|
Human   138 MELHLIHWNSTLFGSIDEAVGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFN 202

  Fly   188 KPVLVADSLAVDDLVPSVENYFTYAGSLTTPTCAEAVTWIVLTETFPVTLD--QVNEFKEI---- 246
            ...|:.|        |.:.:|:.|.||||.|.|:|.||||:.  .:|:|:.  |:.||:.:
Human   203 PNTLLPD--------PLLRDYWVYEGSLTIPPCSEGVTWILF--RYPLTISQLQIEEFRRLRTHV 257

  Fly   247 ---EYDEGKQ--LHNNYRELQSENNRAV 269
               |..||..  |.:|:|..|..::|.:
Human   258 KGAELVEGCDGILGDNFRPTQPLSDRVI 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH7	NP_001287267.1	alpha_CA	45..269	CDD:238200	74/260 (28%)
CA8	NP_001308766.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
CA8	NP_001308766.1	alpha_CARP_VIII	35..289	CDD:239394	76/273 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145779
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750