Protein Alignment CAH7 and CA6

DIOPT Version :10

• Sequence 1: NP_649979.1
• Gene: CAH7 / 41238
• FlyBaseID: FBgn0037788
• Length: 304
• Species: Drosophila melanogaster
• Sequence 2: XP_011540386.1
• Gene: CA6 / 765
• HGNCID: 1380
• Length: 324
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 88/270 - (32%)
• Similarity: 138/270 - (51%)
• Gaps: 36/270 - (13%)

  Fly    20 NEWGYPD--LDN-NQDEPFPKWGGLCDSGKKQSPINL-----HVKGALKGEFDALKFENYDEHQK 76
            ::|.|.:  ||. :..:.:|..|     |::||||||     ....:|||    |....|:....
Human    25 SDWTYSEGALDEAHWPQHYPACG-----GQRQSPINLQRTKVRYNPSLKG----LNMTGYETQAG 80

  Fly    77 NLRMVNNGHSIQLS-GFDHELTLSGGALLQDFVVEQIHMHW--------WSEHTINDIRYPLEVH 132
            ...||||||::|:| .....:|::.|.:   ::.:|:|.||        .||||::.||:.:|:|
Human    81 EFPMVNNGHTVQISLPSTMRMTVADGTV---YIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIH 142

  Fly   133 IVHRNTIYPNMTMAANFKDGIVVIGVLYHVSNTP-NEAIGSIIKSLGAVKSYDSMNKPVLVADSL 196
            |||.|:.|.:..:|.:..||:.|:.....|.|.| |....:.|..|..:| |......:   ..|
Human   143 IVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIK-YPGQRTTL---TGL 203

  Fly   197 AVDDLVP-SVENYFTYAGSLTTPTCAEAVTWIVLTETFPVTLDQVNEFKEIEYD-EGKQLHNNYR 259
            .|.|::| ::::|:||.||||||.|.|.|.|.||.:...::..||.:.:....| ..|.:||:||
Human   204 DVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYR 268

  Fly   260 ELQSENNRAV 269
            ..|..|:|.|
Human   269 RTQPLNHRVV 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH7	NP_649979.1	Carb_anhydrase	38..269	CDD:459707	82/247 (33%)
CA6	XP_011540386.1	alpha_CA_VI	35..283	CDD:239399	85/260 (33%)