DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp13 and Alp12

DIOPT Version :9

Sequence 1:	NP_649978.2	Gene:	Alp13 / 41236	FlyBaseID:	FBgn0037786	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001188848.1	Gene:	Alp12 / 35218	FlyBaseID:	FBgn0032779	Length:	596	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	165/536 - (30%)
Similarity:	252/536 - (47%)	Gaps:	90/536 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TQVFLVAGTCLITVMVTLLCIGFMTRYEVENDVANVADVDYWKDKVATSQKIWYDKGIDELNEAL 83
            :::||:: .....:::|.:||||:..|.:..||.::..|.||...:...||.|||:|||||.:|:
  Fly    61 SRLFLIS-VVFSALLITAMCIGFVVHYGMSGDVGDMETVSYWPVDLPKEQKEWYDQGIDELQKAV 124

  Fly    84 RPQ-DLTYPKNVRIFVIQGIDGRDWAAFRFPTSDASRGNTNFIWDRFPHLARLKNSCSQQFPCQV 147
            ..| :....|||.:||..|:......|.|. ......|...  |::||.:..||..|:.:.....
  Fly   125 SRQFNRRRAKNVILFVGDGMGPNTVTAARI-LGVKEEGLLR--WEQFPDMGLLKTYCADKQVPDS 186

  Fly   148 ASVSRALWLGIPLD--------KVPDNQQDCGRLFNATQGPISILRQAQLAGLRTGFVTTQRITG 204
            .|.:.||:.|:.::        .||  ..:|...........:||:.||:.|:|||||||.|:|.
  Fly   187 FSTATALFGGVKVNYETGGVDANVP--LGNCSASLKEDHHVQTILKWAQVDGMRTGFVTTTRVTH 249

  Fly   205 PTGAAL--GNANGNFECDESMPLNSIKSGCQDIAQQLISDETGKFLNVLIGGGRQMLSSLVPNTK 267
            .|.|||  ...:..:||:..||..:...||.|||:|||...||:.:||::|||||||.|.|..:.
  Fly   250 ATPAALYAHVPDRRWECESGMPAEAQGQGCMDIARQLIEQPTGQSINVIMGGGRQMLVSDVTGSA 314

  Fly   268 YDPVDEMLCESNDGRNLLKDWRNQKLKESKINRIIFDLIQRRDELESLNSSSFDYLMGVMANGDL 332
            .||:|....:|.|||:|::|||.:|..|.    :...::|...||.:||....||::|:.|||.|
  Fly   315 ADPLDTWAGQSKDGRDLIRDWRLKKADEG----VSHAVVQNNRELWNLNGQDVDYVLGIFANGHL 375

  Fly   333 -------SGNSKAPSLKLMVDKSLNVLTKYKQGYLLIVEQFIPSGIDK-----------REQLQL 379
                   ..::..|||..|..|:|.||....:|:||:||..:   ||:           .|.|:|
  Fly   376 MYDHERDRSDAGMPSLSNMTLKALEVLGNSDKGFLLVVEAGL---IDQAHHRGNARKALSEVLEL 437

  Fly   380 ----------------LNDTLV------------NLHKDQDTLTLVLMTNAI---YPKPSLDVSE 413
                            |::|||            |.|.|:.:..|.|..|:.   .|..:|....
  Fly   438 NAAVESTLSFLKSSDRLDETLVIVTADHSHSLTINGHPDRGSSILGLAGNSKTEGTPYTTLTYGT 502

  Fly   414 ETETISLLP----------------EIFNEAESEIQKRLHQMPSESLLFAQGPKSSIFQGVRKET 462
            ..:...:.|                |...:|.....:.||. .|:..:.|.|..|.:|.||.:::
  Fly   503 SYQGFQVDPQTQSRKDPTADDITAWEYTQQAAINTDENLHG-GSDVTIHADGAMSYLFHGVHEQS 566

  Fly   463 FLAHAISHVLSRSRVR 478
            ::|||||:.|...|.|
  Fly   567 YVAHAISYALRIGRFR 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp13	NP_649978.2	ALP_like	127..472	CDD:304875	127/419 (30%)
Alp12	NP_001188848.1	ALP_like	134..579	CDD:304875	138/457 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850