Protein Alignment Alp13 and ALPL

DIOPT Version :10

• Sequence 1: NP_649978.2
• Gene: Alp13 / 41236
• FlyBaseID: FBgn0037786
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_000469.3
• Gene: ALPL / 249
• HGNCID: 438
• Length: 524
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 132/523 - (25%)
• Similarity: 214/523 - (40%)
• Gaps: 119/523 - (22%)

  Fly    23 LVAGTCLITVMVTLLCIGFMTRYEVENDVANVADVDYWKDKVATSQKIWYDKGIDELNEALRPQD 87
            |..||||...:|.          |.|.|                 .|.|.|:..:.|..||..|.
Human     8 LAIGTCLTNSLVP----------EKEKD-----------------PKYWRDQAQETLKYALELQK 45

  Fly    88 L--TYPKNVRIFVIQGIDGRDWAAFRFPTSDASRG---NTNFIWDRFPHLARLKN-SCSQQFPCQ 146
            |  ...|||.:|:..|:......|.|.........   .|....|:||.:|..|. :.:.|.| .
Human    46 LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVP-D 109

  Fly   147 VASVSRALWLGIPLDK------VPDNQQDCGRLFNATQG--PISILRQAQLAGLRTGFVTTQRI- 202
            .|..:.|...|:..::      ....:..|    |.|||  ..||||.|:.||...|.|||.|:
Human   110 SAGTATAYLCGVKANEGTVGVSAATERSRC----NTTQGNEVTSILRWAKDAGKSVGIVTTTRVN 170

  Fly   203 -TGPTGAALGNANGNFECDESMPLNSIKSGCQDIAQQLISDETGKFLNVLIGGGRQMLSSLVPNT 266
             ..|:.|...:|:.::..|..||..::..||:|||.||:.:.  :.::|::||||:.   :.|..
Human   171 HATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNI--RDIDVIMGGGRKY---MYPKN 230

  Fly   267 K----YDPVDEMLCESNDGRNLLKDWRNQK--LKESKINRIIFDLIQRRDELESLNSSSFDYLMG 325
            |    |:..::......||.:|:..|::.|  .|.|       ..|..|.||.:|:..:.|||:|
Human   231 KTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHS-------HFIWNRTELLTLDPHNVDYLLG 288

  Fly   326 VMANGDLS-----GNSKAPSLKLMVDKSLNVLTKYKQGYLLIVE-QFIPSGIDKREQLQLLNDTL 384
            :...||:.     .|...|||..||..::.:|.|..:|:.|:|| ..|..|..:.:..|.|::.:
Human   289 LFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAV 353

  Fly   385 V---------NLHKDQDTLTLVLMT--------------NAIYP-KPSLD--------------- 410
            .         :|...:||||:|...              |:|:. .|.|.
Human   354 EMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNG 418

  Fly   411 -----VSEETETISLLPEIFN--EAESEIQKRLHQMPSESL-LFAQGPKSSIFQGVRKETFLAHA 467
                 |..|.|.:|::....|  :|:|.:..|......|.: :|::||.:.:..||.::.::.|.
Human   419 PGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHV 483

  Fly   468 ISH 470
            :::
Human   484 MAY 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp13	NP_649978.2	ALP_like	127..472	CDD:474031	107/414 (26%)
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:395188	115/453 (25%)