Protein Alignment Alp13 and ALPI

DIOPT Version :10

• Sequence 1: NP_649978.2
• Gene: Alp13 / 41236
• FlyBaseID: FBgn0037786
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001622.2
• Gene: ALPI / 248
• HGNCID: 437
• Length: 528
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 124/481 - (25%)
• Similarity: 212/481 - (44%)
• Gaps: 111/481 - (23%)

  Fly    71 WYDKGIDELNEALRPQDL-TYPKNVRIFVIQGIDGRDWAAFRFPTSDASR---GNTN-------- 123
            |..:..:.|:.|.:.|.: ...||:.:|:..|:.        .||..|:|   |..|
Human    31 WNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLG--------VPTVTATRILKGQKNGKLGPETP 87

  Fly   124 FIWDRFPHLARLKN-SCSQQFPCQVASVSRALWLGIPLDKVPDNQQDCG-------RLFNATQG- 179
            ...||||:||..|. :..:|.|...|:.:..|.      .|..|.|..|       ...|.|:|
Human    88 LAMDRFPYLALSKTYNVDRQVPDSAATATAYLC------GVKANFQTIGLSAAARFNQCNTTRGN 146

  Fly   180 -PISILRQAQLAGLRTGFVTTQRI--TGPTGAALGNANGNFECDESMPLNSIKSGCQDIAQQLIS 241
             .||::.:|:.||...|.|||.|:  ..|.|......|.|:..|..||.::.:.||||||.||||
Human   147 EVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLIS 211

  Fly   242 DETGKFLNVLIGGGRQMLSSL-VPNTKYDPVDEMLCESN----DGRNLLKDWRNQKLKESKINRI 301
            :..   ::|::||||:.:..: .|:.:| |.|   ...|    ||:||:::|..:       ::.
Human   212 NMD---IDVILGGGRKYMFPMGTPDPEY-PAD---ASQNGIRLDGKNLVQEWLAK-------HQG 262

  Fly   302 IFDLIQRRDELESLNSSSFDYLMGVMANGDLS-----GNSKAPSLKLMVDKSLNVLTKYKQGYLL 361
            .:.:..|.:.:::....|..:|||:...||..     ..:..|||..|.:.:|.:|::..:|:.|
Human   263 AWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYL 327

  Fly   362 IVE-QFIPSGIDKREQLQLLNDTLV---------NLHKDQDTLTLV--------------LMTNA 402
            .|| ..|..|..:....|.|.:.::         .|..::||||||              |..::
Human   328 FVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSS 392

  Fly   403 IY---PKPSLDVSEETETI-----------SLLPEIFNEAESEI----QKRLHQMPSES------ 443
            |:   |..:.|....|..:           .:.|:: ||:||..    |:....:.||:
Human   393 IFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDV-NESESGSPDYQQQAAVPLSSETHGGEDV 456

  Fly   444 LLFAQGPKSSIFQGVRKETFLAHAIS 469
            .:||:||::.:..||::::|:||.::
Human   457 AVFARGPQAHLVHGVQEQSFVAHVMA 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp13	NP_649978.2	ALP_like	127..472	CDD:474031	110/413 (27%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:395188	120/460 (26%)