DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp13 and Alppl2

DIOPT Version :9

Sequence 1:	NP_649978.2	Gene:	Alp13 / 41236	FlyBaseID:	FBgn0037786	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_031459.3	Gene:	Alppl2 / 11650	MGIID:	108009	Length:	529	Species:	Mus musculus

Alignment Length:	515	Identity:	125/515 - (24%)
Similarity:	215/515 - (41%)	Gaps:	107/515 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GTCLITVMVTLLCIGFMTRYEVENDVANVADVDYWKDKVATSQKIWYDKGIDELNEALRPQDLTY 90
            |.||:.:.::|.....:...|.||..       :|..|.|        :.:|...: |:|.. |.
Mouse     3 GACLLLLGLSLQVCPSVIPVEEENPA-------FWNRKAA--------EALDAAKK-LKPIQ-TS 50

  Fly    91 PKNVRIFVIQGIDGRDWAAFRFPTSDASRGN----TNFIWDRFPHLARLKN-SCSQQFPCQVASV 150
            .||:.|.:..|:......|.|. .....:|:    |....|||||:|..|. :..:|.| ..|..
Mouse    51 AKNLVILMGDGMGVSTVTATRI-LKGQQQGHLGPETQLAMDRFPHMALSKTYNTDKQIP-DSAGT 113

  Fly   151 SRALWLGIPLDKVPDNQQDCGRL--FNATQG--PISILRQAQLAGLRTGFVTTQRI--TGPTGAA 209
            ..|...|:..:..........|.  .|.|.|  .:|::.:|:.||...|.|||..:  ..|.|..
Mouse   114 GTAFLCGVKTNMKVIGLSAAARFNQCNTTWGNEVVSVMHRAKKAGKSVGVVTTTSVQHASPAGTY 178

  Fly   210 LGNANGNFECDESMPLNSIKSGCQDIAQQLISDETGKFLNVLIGGGRQ-MLSSLVPNTKYDPVDE 273
            ....|..:..|..||.::::.||:||:.||||:..   ::|::||||: |.....|:.:| |.|.
Mouse   179 AHTVNRGWYSDAQMPASALQDGCKDISTQLISNMD---IDVILGGGRKFMFPKGTPDQEY-PTDT 239

  Fly   274 MLCESN-DGRNLLKDWRNQKLKESKINRIIFDLIQRRDEL--ESLNSSSFDYLMGVMANGDLS-- 333
            ....:. |||||:::|    |.:.:..|.:::    |.||  .||| .|..:|||:....|:.
Mouse   240 KQAGTRLDGRNLVQEW----LAKHQGARYVWN----RSELIQASLN-RSVTHLMGLFEPNDMKYE 295

  Fly   334 ---GNSKAPSLKLMVDKSLNVLTKYKQGYLLIVE--------------------QFIPSGIDKRE 375
               ..::.|||..|.:.::.:|::..:|:.|.||                    ....|.:||.:
Mouse   296 IHRDPAQDPSLAEMTEVAVRMLSRNPKGFYLFVEGGRIDHGHHETVAYRALTEAVMFDSAVDKAD 360

  Fly   376 QLQLLNDTLV-----NLH----------------------KDQDTLTLVLMTNA----IYPKPSL 409
            :|....||::     :.|                      :|..:.|.:|..|.    ::.....
Mouse   361 KLTSEQDTMILVTADHSHVFSFGGYTQRGASIFGLAPFKAEDGKSFTSILYGNGPGYKLHNGARA 425

  Fly   410 DVSEETETISLLPEIFNEAESEIQKRLHQMPSESLLFAQGPKSSIFQGVRKETFLAHAIS 469
            ||:||.   |..|....:|...:....|. ..:..:||:||::.:..||:::.::||.::
Mouse   426 DVTEEE---SSNPTYQQQAAVPLSSETHS-GEDVAIFARGPQAHLVHGVQEQNYIAHVMA 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp13	NP_649978.2	ALP_like	127..472	CDD:304875	103/410 (25%)
Alppl2	NP_031459.3	Alk_phosphatase	51..486	CDD:333956	111/450 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847863
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.700