DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp13 and Alpp

DIOPT Version :9

Sequence 1:	NP_649978.2	Gene:	Alp13 / 41236	FlyBaseID:	FBgn0037786	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	XP_002730104.3	Gene:	Alpp / 100359675	RGDID:	2325055	Length:	529	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	127/517 - (24%)
Similarity:	210/517 - (40%)	Gaps:	111/517 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GTCLITVMVTLLCIGFMTRYEVENDVANVADVDYWKDKVATSQKIWYDKGIDELNEALRPQDL-T 89
            |.||:.:.::|.....:...|.||..       :|..|.|           :.|..|.:.|.: |
  Rat     3 GACLLLLGLSLQMSLSLVPVEEENPA-------FWNRKAA-----------EALEAAKKLQPIQT 49

  Fly    90 YPKNVRIFVIQGIDGRDWAAFRFPTSDASRGN----TNFIWDRFPHLARLKN-SCSQQFPCQVAS 149
            ...|:.|.:..|:......|.|. .....:|:    |....|||||:|..|. :..:|.| ..|.
  Rat    50 SANNLIILMGDGMGVSTVTATRI-LKGQQQGHLGPETPLAMDRFPHMALSKTYNTDKQVP-DSAG 112

  Fly   150 VSRALWLGIPLDKVPDNQQDCGRL--FNATQG--PISILRQAQLAGLRTGFVTTQRI--TGPTGA 208
            ...|...|:..:..........|.  .|.|.|  .:|::.:|:.||...|.|||..:  ..|.|.
  Rat   113 TGTAFLCGVKTNMKVIGLSAAARFNQCNTTWGNEVVSVMHRAKKAGKSVGVVTTTSVQHASPAGT 177

  Fly   209 ALGNANGNFECDESMPLNSIKSGCQDIAQQLISDETGKFLNVLIGGGRQ-MLSSLVPNTKYDPVD 272
            .....|.|:..|..|...:::.||:|||.||||:..   ::|::||||: |.....|:.:| |.|
  Rat   178 YAHTVNRNWYSDAHMSTAALQEGCKDIAMQLISNTD---IDVILGGGRKFMFPKGTPDQEY-PTD 238

  Fly   273 EMLCESN-DGRNLLKDWRNQKLKESKI-NRIIFDLIQRRDELESLNSSSFDYLMGVMANGDLSGN 335
            .....:. |||||:::|..:......: ||.  :|||     .||| .|..:|||:....|:..|
  Rat   239 PQQAGTRLDGRNLVQEWLAKHQGAQYVWNRT--ELIQ-----ASLN-RSVTHLMGLFEPNDMKYN 295

  Fly   336 -----SKAPSLKLMVDKSLNVLTKYKQGYLLIVE--------------------QFIPSGIDKRE 375
                 ::.|||..|.:.::::|::..:|:.|.||                    ....|.:||.:
  Rat   296 IDRDPTQDPSLAEMTEVAVHMLSRNPKGFYLFVEGGRIDHGHHEAIAYRALTEAVMFDSAVDKAD 360

  Fly   376 QLQLLNDTLVNLHKDQD---------------------------TLTLVLMTNAIYPKPSL---- 409
            :|....||::.:..|..                           :.|.:|..|.  |...|
  Rat   361 KLTSEKDTMIIVTADHSHVFSFGGYTQREASIFGLAPFKAGDGKSFTSILYGNG--PGYKLNNGI 423

  Fly   410 --DVSEETETISLLPEIFNEAESEIQKRLHQMPSESLLFAQGPKSSIFQGVRKETFLAHAIS 469
              ||:||.   |..|....:|...:....|. ..:..:||:||::.:..||:::.::||.::
  Rat   424 RADVTEEE---SSNPTYQQQAAVPLSSETHS-GEDVAIFARGPQAHLVHGVQEQNYIAHVMA 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp13	NP_649978.2	ALP_like	127..472	CDD:304875	106/411 (26%)
Alpp	XP_002730104.3	Alk_phosphatase	51..486	CDD:395188	113/451 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351440
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850