DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp13 and alp3

DIOPT Version :9

Sequence 1:	NP_649978.2	Gene:	Alp13 / 41236	FlyBaseID:	FBgn0037786	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001265768.1	Gene:	alp3 / 100330410	ZFINID:	ZDB-GENE-120919-1	Length:	534	Species:	Danio rerio

Alignment Length:	512	Identity:	123/512 - (24%)
Similarity:	216/512 - (42%)	Gaps:	101/512 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LITVMVTLLC-IGFMTRYEVENDVANVADVDYWKDKVATSQKIWYDKGIDELNEAL-RPQDLTYP 91
            :..|.|:::| :..:|...||.:     :.::|:.....:           |..|| |..:....
Zfish     1 MFAVRVSVVCFLLTITSGSVEEE-----NPEFWRKSAQNT-----------LRSALSRKINTNVA 49

  Fly    92 KNVRIFVIQGIDGRDWAAFRFPTSDASRGN---TNFIWDRFPHLARLK-NSCSQQFPCQVASVSR 152
            ||:.:|:..|:......|.|.......:.:   |....|.||::...| .|...|.|...|:.:.
Zfish    50 KNIVLFLGDGMGVTTITAARILKGQLQKHSGEETVMNMDTFPNVGLAKVYSVDFQIPDSAATATA 114

  Fly   153 ALWLGIPLDKVPDNQQDCGRLFNATQG---------PISILRQAQLAGLRTGFVTTQRITGPTGA 208
            .|.      .|..|....|....|..|         ..||||.|:.||...|.|||.|:...|.|
Zfish   115 YLC------GVKTNLNTVGVSAAARNGVCRSQKGNEVTSILRWAKDAGKSVGIVTTTRVQHATPA 173

  Fly   209 A--LGNANGNFECDESMPLNSIKSGCQDIAQQLISDETGKFLNVLIGGGRQ-MLSSLVPNTKYDP 270
            |  ..:|:..:..|..:|.::...||.|||.||:.:..   ::|:|||||: |.....|:.:|..
Zfish   174 ASFAHSASRTWYSDADLPASAATEGCVDIATQLLHNID---IDVIIGGGRKYMTPKGFPDPEYPS 235

  Fly   271 VDEMLCESNDGRNLLKDWRNQKLKESKINRIIFDLIQRRDELESLNSSSFDYLMGVMANGDL--- 332
            ......:..|||||::||  .::||.|:.|.:::    :.:.::::....||||.:....||
Zfish   236 DASAQGQRRDGRNLIQDW--IQMKEGKVARYVWN----KTDFDAVDPEKTDYLMALFEPADLRFD 294

  Fly   333 --SGNSKAPSLKLMVDKSLNVLTKYKQGYLLIVE-QFIPSGIDKREQLQLLNDTL---------V 385
              ..:|..||:....||::.:|.|..:|:.|:|| ..|..|.........|::.:         :
Zfish   295 VERDHSMDPSISETTDKAIQILKKNPKGFFLLVEGGRIDQGHHSSRASAALHEAVALDEAVSRGL 359

  Fly   386 NLHKDQDTLTLV--------------LMTNAIYPKPSLDVSEETETISLL------PEIFNEAES 430
            .|..:::|||:|              ...|:|..|..:..|:.....:|:      .:|.|....
Zfish   360 ELTDEEETLTIVTADHSHAFTFNGYPFRGNSILGKSPIFASDFLPYTTLMYGNGPGHKITNNKRP 424

  Fly   431 EIQK---------RLHQMPSES--------LLFAQGPKSSIFQGVRKETFLAHAISH 470
            :|:|         :...:|.:|        .:||:||.:.:||||.::.::.||:::
Zfish   425 DIRKVDTADKDYIQQSAVPLDSETHGGEDVAVFARGPMAHLFQGVYEQNYIPHAMAY 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp13	NP_649978.2	ALP_like	127..472	CDD:304875	105/409 (26%)
alp3	NP_001265768.1	PhoA	30..482	CDD:224699	116/478 (24%)
alp3	NP_001265768.1	Alk_phosphatase	49..485	CDD:278666	112/448 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593226
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850