DRSC/TRiP Functional Genomics Resources

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Protein Alignment nerfin-2 and INSM2

DIOPT Version :9

Sequence 1:NP_001262446.1 Gene:nerfin-2 / 41235 FlyBaseID:FBgn0041105 Length:775 Species:Drosophila melanogaster
Sequence 2:NP_115983.3 Gene:INSM2 / 84684 HGNCID:17539 Length:566 Species:Homo sapiens


Alignment Length:436 Identity:113/436 - (25%)
Similarity:145/436 - (33%) Gaps:190/436 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   297 EELHNQAVNGLARLFDRDFPEPDVEVSGL----AELQSNSGKTYTDLS----GVATAEIRTTSSD 353
            ||..:.::.|..|.......||.   .||    |..||.|......:|    |...||.|....:
Human    39 EEAPSASLPGAERATPPTREEPG---KGLTAEAAREQSGSPCRAAGVSPGTGGREGAEWRAGGRE 100

  Fly   354 NLPPPPPPPPPPA------------------------------------TSTIPATPPLP----- 377
            ...|.|.|.|.||                                    .|..||..|.|     
Human   101 GPGPSPSPSPSPAKPAGAELRRAFLERCLSSPVSAESFPGGAAAVAAFSCSVAPAAAPTPGEQFL 165

  Fly   378 -------PPPISRPHKAE--------------RRRSK-------------------LRKHMAIDE 402
                   |.|..:|..|.              .||.|                   :||....||
Human   166 LPLRAPFPEPALQPDPAPLSAALQSLKRAAGGERRGKAPTDCASGPAAAGIKKPKAMRKLSFADE 230

  Fly   403 ETISPVSGTIIRKLRDDEELVVRKGDIDPAFNVVEITEEAKAILASIDNKIGDYMCQLCRTVYDD 467
            .|.|||.|.   |::::|.....:|                  |......:|:::||||:..|.|
Human   231 VTTSPVLGL---KIKEEEPGAPSRG------------------LGGSRTPLGEFICQLCKEQYAD 274

  Fly   468 AFMLAQHRCPRIVHIEYKCSECEKVFNCPANLASHRRWHKPK---AEAAGVNPA----------- 518
            .|.||||||.|||.:||:|.||:|||:||||||||||||||:   |.||.|:.|           
Human   275 PFALAQHRCSRIVRVEYRCPECDKVFSCPANLASHRRWHKPRPAAANAATVSSADGKPPSSSSSS 339

  Fly   519 ----------------KKRVVETGDLVQEA----------------------------------- 532
                            ..|:..|.|...:|                                   
Human   340 SRDSGAIASFLAEGKENSRIERTADQHPQARDSSGADQHPDSAPRQGLQVLTHPEPPLPQGPYTE 404

  Fly   533 -----------TRSGDDASDGIYPCHICGKTFRRQAYLKKHQASHQ 567
                       :.||...|: |:.|..|.|.|||||||:||.::|:
Human   405 GVLGRRVPVPGSTSGGRGSE-IFVCPYCHKKFRRQAYLRKHLSTHE 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nerfin-2NP_001262446.1 C2H2 Zn finger 458..481 CDD:275368 15/22 (68%)
C2H2 Zn finger 486..506 CDD:275368 16/19 (84%)
zf-C2H2 544..566 CDD:278523 12/21 (57%)
C2H2 Zn finger 546..566 CDD:275368 12/19 (63%)
INSM2NP_115983.3 SNAG domain. /evidence=ECO:0000250 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..117 23/80 (29%)
PdxA 140..>203 CDD:294567 11/62 (18%)
C2H2 Zn finger 265..285 CDD:275368 13/19 (68%)
zf-C2H2 291..313 CDD:278523 17/21 (81%)
C2H2 Zn finger 293..313 CDD:275368 16/19 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..418 15/107 (14%)
zf-C2H2 426..448 CDD:278523 12/21 (57%)
C2H2 Zn finger 428..448 CDD:275368 12/19 (63%)
C2H2 Zn finger 472..492 CDD:275368
C2H2 Zn finger 527..548 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3993
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002683
OrthoInspector 1 1.000 - - mtm8472
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR15065
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3291
SonicParanoid 1 1.000 - - X1791
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.900

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